“…Evidence suggesting that primary tubular preponderance may play a part in the genesis of edema in the nephrotic syndrome has been reviewed recently (2). Possible factors are antidiuretic substances and adrenal cortical hormones (36,37,(47)(48)(49)(50)(51)(52)(53)(54)(55), increased intrarenal pressure due to renal interstitial edema or to ascites (29,(56)(57)(58) Berne (64). Nothing is as yet known of the mechanisms whereby any of these factors are brought into operation.…”