Effect of increased pump flow on hepatic blood flow and systemic inflammatory response following on-pump coronary artery bypass grafting

Adluri, Rajeshwara Krishna Prasad; Singh, Avadhesh Pratap; Skoyles, Julian; Hitch, Tony; Robins, Adrian; Baker, Mya; Mitchell, Ian M.

doi:10.1177/0267659110378843

Cited by 4 publications

(1 citation statement)

References 16 publications

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“…Furthermore, Adluri and his colleagues found that the reduced hepatic blood flow when commencing CPB can be balanced by an increase of the pump flow rate by 20%. [17] For their study they used the indocyanine green method which measured its percentage dye, and therefore overwhelmed the difficulty of the dual blood supply to the liver. In addition, reduction of blood flow through the splanchnic circulation cause to endotoxemia as it may end to the failure of the mucosal barrier in the GI tract.…”

Section: Blood Flow During Cpb: Goals and Requirementsmentioning

confidence: 99%

Advanced Perfusion Techniques - Flow versus Pressure

Pappa¹,

Theodosiadis²,

Paliouras³

et al. 2017

J. Biomed

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Cardiac operations which require Cardiopulmonary bypass (CPB) are considered the most common procedures in cardiac surgery, performed for more than half a century, especially in Europe and North America. Despite that new technologies are being incorporated in CPB as long as the development of new techniques in CPB, some debates still remain. These debates regard the achievement of the needed optimal perfusion during CPB and the relation between perfusion pressures and the optimal blood flow during extracorporeal circulation. Blood flow and blood pressure during Cardiopulmonary bypass are very important factors. Although more studies are in favor of a minor superiority of the optimal blood flow requirements, compared to the corresponding optimal blood pressure needs, their role is quite interdependent. The usage of contemporary electronic Data Management Systems (DMS) led to a significant evolution of the perfusion science. Adequate perfusion can now be judged by its results in real time, while information from DMS, such as venous saturation, levels of haemoglobin and lactate, may be used as the markers of optimal perfusion and additionally for the development of the perfusion protocols in the future.

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Section: Blood Flow During Cpb: Goals and Requirementsmentioning

confidence: 99%