Effect of in vivo administration of somatostatin on cell-free protein synthesis of pituitary and of adrenal ribosomes

Tragl, Karl-Heinz; Kinast, H.; H, Steininger; Geyer, G

doi:10.1016/0026-0495(78)90080-x

Search citation statements

Order By: Relevance

Paper Sections

Select...

Other Actions Of Somatostatin1

Discussion1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1981

1991

Publication Types

Select...

Article4

Book1

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 5 publications

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It even inhibits granuloma formation (154). Release of histamine has been reported to be unaffected or stimulated by somatostatin (155).…”

Section: Other Actions Of Somatostatinmentioning

confidence: 98%

Physiology and Pharmacology of LHRH and Somatostatin

McCann¹

1982

Annu. Rev. Pharmacol. Toxicol.

View full text Add to dashboard Cite

“…It even inhibits granuloma formation (154). Release of histamine has been reported to be unaffected or stimulated by somatostatin (155).…”

Section: Other Actions Of Somatostatinmentioning

confidence: 98%

Physiology and Pharmacology of LHRH and Somatostatin

McCann¹

1982

Annu. Rev. Pharmacol. Toxicol.

View full text Add to dashboard Cite

“…The cell affecting mechanism of somatostatin at physiologic concentrations seems to be very complex in respect to the different receptors found at the adrenal cell surface {Hall 1977). Furthermore intracellular sites of peptide hormone action {Tragi, Kinast, Steiniger and Geyer 1978) and somatostatin binding factors other than receptor binding, might be of relevance {Diel, Schneider and Baumann 1977).…”

Section: Discussionmentioning

confidence: 99%

Failure of Somatostatin and β-Endorphin to Affect Bovine Adrenal Cortex Cells In Vitro

Diel¹,

Holz²,

Bethge³

1981

Horm Metab Res

View full text Add to dashboard Cite

The main intention of this study was to examine the effect of cyclic somatostatin (SRIF) on bovine adrenal cell activity in vitro. beta-Endorphin was applied in another course of experiments. Basal aldosterone secretion when measured was found to be 0.86 +/- 0.33 ng per 10(5) cells and 1.5 h incubation time in the glomerulosa cell fractions. Cortisol production was 1.6 +/- 0.3 ng per 10(5) cells in the fasciculata/reticularis cell incubates respectively. No effect was observed when cyclic somatostatin (SRIF) was added to cell incubates of the bovine adrenal cortex. However, aldosterone secretion was increased 4.5-fold in the presence of 10(-9)M ACTH or 10(-8)M At II. Cortisol production was enhanced similarly after addition of 10(-9)M ACTH.

show abstract

Failure of somatostatin to influence experimental tumor cell growth in vivo and in vitro

et al. 1981

View full text Add to dashboard Cite

The influence of somatostatin on tumor cell growth was studied in vivo in mice (sarcoma 180 ascites tumor and Lewis lung tumor) and in vitro on nontransformed and polyoma-transformed cell lines. 4 or 20 micrograms/100 g of cyclic somatostatin and 4 micrograms/100 g of linear protamin Zn-bound somatostatin were injected s.c. twice daily in the in vivo study. Cyclic somatostatin (1, 4 or 10 micrograms/ml) was added twice daily to the cell cultures. Somatostatin administration influenced neither the survival of animals nor the growth rate of cultured cell lines.

show abstract

Effect of in vivo administration of somatostatin on cell-free protein synthesis of pituitary and of adrenal ribosomes

Cited by 5 publications

References 14 publications

Physiology and Pharmacology of LHRH and Somatostatin

Physiology and Pharmacology of LHRH and Somatostatin

Failure of Somatostatin and β-Endorphin to Affect Bovine Adrenal Cortex Cells In Vitro

Failure of somatostatin to influence experimental tumor cell growth in vivo and in vitro

Contact Info

Product

Resources

About