Effect of in utero hypoxia on the ouabain/strophanthidin binding site of the fetal guinea pig brain cell membrane Na+,K+-ATPase

Fetal brain hypometabolism during prolonged hypoxaemia in the llama

“…Hypoxia or hypoxia/ischaemia decreases brain Na + –K + ‐ATPase activity in newborn lambs and piglets and in preterm guinea pigs fetuses. These authors interpreted the reduction of Na + –K + ‐ATPase activity as damage in the enzyme produced by reactive oxygen species and as sign of brain damage (Groenendaal et al 2000; Rosenkrantz et al 1996; and Graham et al 1995). Alternatively in the anoxic turtle, the reduced Na + –K + ‐ATPase activity without cell depolarization observed in hepatocytes, or the reversible inhibition of Na + –K + ‐ATPase activity measured in telencephalon and cerebellum, has been considered as part of the channel arrest mechanism to adapt the metabolism to oxygen lack (Buck & Hochachka, 1993; Hylland et al 1997).…”

Regulation of Na+,K+‐ATPase α Subunit Isoforms in Mouse Cortex during Focal Ischemia

“…Functional reduction in sodium pump capacity may be an important factor in hyperexcitability, homeostasis dysregulation, and neuronal death. Nonetheless, little evidence of eventual modulation of cerebral Na + ,K + ‐ATPase activity via its three isoforms in pathology such as ischemic injury is available today 2,3 . To explore the incidence of ischemic brain damage on the Na + ,K + ‐ATPase and its isoforms, the present study of adult mice examines the effect of ischemia on the affinity of the binding sites for ouabain of the Na + ,K + ‐ATPase and on the regulation of mRNA expression of the α isoforms of the Na + ,K + ‐ATPase.…”