Effect of Implementing Exercise Program on Pain and Physical Functions among Patients with Moderate Knee Osteoarthritis

Ali, Ayat Ahmed; Mohamed, Hanan Gaber; Ali, Heba Abdelkader; Hassan, Mohamed; Ali, Mohamed R.

doi:10.21608/jnsbu.2022.247762

Cited by 1 publication

(1 citation statement)

References 3 publications

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“…Knee OA (KOA) is the most frequent arthropathies worldwide with a prevalence of 365 million of the adult population (9). In Egypt, KOA prevalence is about 29.2 per 1000 which imposes a serious public health problem (10). KOA is a multifactorial disease where risk factors at the joint level (abnormal loading of the joints, injury, mechanical stress, and malalignment) and person-level risk factors (age, gender, obesity, diet, occupation, metabolic syndromes as diabetes, and genetics) are all engaged in the development of the disease.…”

Section: Introductionmentioning

confidence: 99%

The association between ADAMTS14/rs4747096 gene polymorphism and some risk factors and knee osteoarthritis

Elshaarawy,

Salama,

Salama

et al. 2024

Preprint

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Aim To examine the connection between SNPs of ADAMTS14 gene rs4747096 and KOA and to assess risk factors associated with KOA. Methods A case control study was conducted on 158 patients with KOA and 120 controls with comparable age and sex randomly recruited from National Research Centre employees. All participants were subjected to full history taking, assessment of KOA severity using WOMAC scoring system, and thorough clinical examination. Blood sample was collected for detection of ADAMTS14/rs4747096 gene polymorphism. Results The frequency of ADAMTS14 gene rs4747096 genotypes among patients with KOA was for AA 73.5%, AG 25.7% and GG 0.7% compared to controls 963%, 31.3% and 5.6% respectively and the frequency of alleles among patients was for A 86.4% and G 78.7% compared to controls (78.7% and 21.3% respectively, P < 0.05. The study found that the median levels of total WOMAC score and its domains were significantly higher among KOA patients than controls. The logistic regression analysis revealed that older age, BMI ≥ 35, long standing at work, and severe physical exercise were predictive factors for KOA (P < 0.01). Conclusion For ADAMTS14 rs4747096 genotype, the AA and AG genotypes significantly increased the risk of KOA. Older age, females, morbid obesity, prolonged standing at work, and severe physical exercise were risk factors for KOA. Further studies are encouraged to investigate the mechanism by which this genotype can affect the development of KOA.

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Section: Introductionmentioning

confidence: 99%