Effect of immunosuppressive medication on postoperative complications following abdominal surgery in Crohn’s disease patients

Lahes, Saleh; Fischer, Celine; Spiliotis, Antonios E.; Schulz, Antonia; Gäbelein, Gereon; Igna, Dorian; Glanemann, Matthias

doi:10.1007/s00384-022-04287-4

Cited by 3 publications

(4 citation statements)

References 33 publications

(39 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The impact of medical treatment on postoperative complications has long been discussed. In contrast to previous studies [24], but in line with others [27], preoperative steroid exposure was not significantly associated with postoperative complications in this study. In a very recent retrospective study, 426 patients with CD who underwent abdominal surgery between 2001 and 2018 were divided into two groups [27].…”

Section: Discussionsupporting

confidence: 67%

“…In contrast to previous studies [24], but in line with others [27], preoperative steroid exposure was not significantly associated with postoperative complications in this study. In a very recent retrospective study, 426 patients with CD who underwent abdominal surgery between 2001 and 2018 were divided into two groups [27]. Patients in the first group were receiving immunosuppressive medication at the time of surgery, whereas patients in the second group had never had pharmacological therapy for CD prior to surgery.…”

Section: Discussionsupporting

confidence: 67%

“…Patients in the first group were receiving immunosuppressive medication at the time of surgery, whereas patients in the second group had never had pharmacological therapy for CD prior to surgery. There was no statistically significant difference in postoperative complications between the two groups [27]. The risk of postoperative complications associated with anti-TNF-α agents in CD remains debatable, with no clear consensus [21].…”

Section: Discussionmentioning

confidence: 90%

See 2 more Smart Citations

Risk Factors for Complications and Disease Recurrence after Ileocecal Resection for Crohn’s Disease in Children and Adults

Dipasquale,

Milone,

Nigro

et al. 2024

Biomedicines

View full text Add to dashboard Cite

This study reports the complication and disease recurrence rates for ileocecal resection for pediatric and adult Crohn’s disease (CD) and identifies perioperative risk factors for these adverse outcomes in the two groups. Patients who underwent ileocecal resection for CD in a tertiary hospital in Italy (2010–2021) were included. Risk factors for postoperative complications and clinical and surgical disease recurrences were investigated with multivariate models. A total of 96 patients were included (children, 25%). There were no intraoperative complications. Thirty-one (32.3%) patients experienced 35 (36.5%) postoperative complications, and five (5.2%) were severe (Clavien–Dindo III–IV–V), with no intergroup difference for either overall postoperative complication rate (p = 0.257) or severe postoperative complication rate (p = 0.097). Most of these (77.1%) occurred within 30 days after surgery, especially in adults (p = 0.013). The multivariate analysis did not show risk factors for postoperative complications. Clinical and surgical recurrence rates after 5 years were 46.8% and 14.6%, respectively, with no intergroup rate differences. Clinical disease recurrence was positively correlated with previous abdominal surgery (p = 0.047) and negatively correlated with preoperative Hb levels (p = 0.046). A positive correlation was found between perianal disease and both clinical (p = 0.045) and surgical disease recurrences (p = 0.045). Urgent surgery was positively associated with surgical disease recurrence (p = 0.045). Notably, no children underwent urgent surgery in this study. In conclusion, the risk of postoperative complications among CD patients receiving ileocecal resection remains high, but most of them are nonserious. Some factors, such as urgent surgery, may increase the risk of disease recurrences.

show abstract

Section: Discussionsupporting

confidence: 67%

Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 90%

See 1 more Smart Citation

Risk Factors for Complications and Disease Recurrence after Ileocecal Resection for Crohn’s Disease in Children and Adults

Dipasquale,

Milone,

Nigro

et al. 2024

Biomedicines

View full text Add to dashboard Cite

show abstract

“…The presence of stulas or perforations was shown to be associated with a higher rate of complications than other indications (4,5).…”

Section: Introductionmentioning

confidence: 93%

Stapled Versus Hand-Sewn Anastomoses After Bowel Resection in Patients With Crohn Disease

Lahes

Fischer

Igna

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

Background: Anastomosis configuration is an essential step in treatment to restore continuity of the gastrointestinal tract following bowel resection in patients with Crohn’s disease (CD). However, the association between anastomotic type and surgical outcome remains controversial. This retrospective study aimed to compare early postoperative complications and surgical outcome between stapler and handsewn anastomosis after bowel resection in Crohn’s disease. Methods: Between 2001 and 2018, a total of 339 CD patients underwent bowel resection with anastomosis. Patient characteristics, intraoperative data, early postoperative complications, and outcomes were analyzed and compared between two groups of patients. Group 1 consisted of patients with stapler anastomosis and group 2 with handsewn anastomosis. Results: No significant difference was found in the incidence of postoperative surgical complications between the stapler and handsewn anastomosis groups (25% versus 24.4%, p =1.000). Reoperation for complications and postoperative hospital stay were similar between the two groups. Conclusion: Our analysis showed that there were no differences in anastomotic leak, nor postoperative complications, mortality, reoperation for operative complications, or postoperative hospital stay between the stapler anastomosis and handsewn anastomosis groups.

show abstract

Stapled versus hand-sewn anastomoses after bowel resection in patients with crohn disease

Lahes,

Fischer,

Igna

et al. 2024

BMC Surg

View full text Add to dashboard Cite

Background Anastomosis configuration is an essential step in treatment to restore continuity of the gastrointestinal tract following bowel resection in patients with Crohn’s disease (CD). However, the association between anastomotic type and surgical outcome remains controversial. This retrospective study aimed to compare early postoperative complications and surgical outcome between stapler and handsewn anastomosis after bowel resection in Crohn’s disease. Methods Between 2001 and 2018, a total of 339 CD patients underwent bowel resection with anastomosis. Patient characteristics, intraoperative data, early postoperative complications, and outcomes were analyzed and compared between two groups of patients. Group 1 consisted of patients with stapler anastomosis and group 2 with handsewn anastomosis. Results No significant difference was found in the incidence of postoperative surgical complications between the stapler and handsewn anastomosis groups (25% versus 24.4%, p = 1.000). Reoperation for complications and postoperative hospital stay were similar between the two groups. Conclusion Our analysis showed that there were no differences in anastomotic leak, nor postoperative complications, mortality, reoperation for operative complications, or postoperative hospital stay between the stapler anastomosis and handsewn anastomosis groups.

show abstract

Effect of immunosuppressive medication on postoperative complications following abdominal surgery in Crohn’s disease patients

Cited by 3 publications

References 33 publications

Risk Factors for Complications and Disease Recurrence after Ileocecal Resection for Crohn’s Disease in Children and Adults

Risk Factors for Complications and Disease Recurrence after Ileocecal Resection for Crohn’s Disease in Children and Adults

Stapled Versus Hand-Sewn Anastomoses After Bowel Resection in Patients With Crohn Disease

Stapled versus hand-sewn anastomoses after bowel resection in patients with crohn disease

Contact Info

Product

Resources

About