Effect of Immunosuppressive Agents on Retention of Antigen in the Mouse Spleen

Nettesheim, Paul; Hammons, A.S.

doi:10.3181/00379727-133-34547

Cited by 20 publications

(5 citation statements)

References 4 publications

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“…He responded well to local and systemic steroid treatment. That steroids may have actually promoted clearance of antigen is supported by the work of Netterheim and Hamous 14 who showed that corticosteroids given in vivo reduced the retention of antigen in germinal centers in lymph nodes, possibly by an effect on the surface of dentritic macrophages.…”

Section: Discussionmentioning

confidence: 58%

Intestinal Parasites: Incidence and Etiology in over 1,000 Patients at King Faisal Specialist Hospital in Riyadh

Qadri

Khalil

1987

Ann Saudi Med

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T-lymphocyte phenotypes and human leukocyte antigen-DR expression (HLA-DR) expression in skin lesions and draining lymph nodes of zoonotic leishmaniasis caused by Leishmania major were studied. T lymphocytes were the dominant cells in the lymphocytic preponderance type of lesion. They were lowest when the parasitized macrophage was the dominant cell or when the reaction consisted of an equal admixture of lymphocytes, macrophages and plasma cells. Both inducer/helper and suppressor/cytotoxic T cells were present in varying proportions. The latter were thought to be suppressor rather than cytotoxic cells. Their late appearance in the host reaction was believed to play a major role in halting the inflammatory response. Low levels of cells expressing the suppressor/cytotoxic phenotype and the continued presence of antigen in macrophages was associated with persistence of the lesions even when parasites were largely eliminated after specific antileishmanial therapy. Such lesions healed after local or systemic steroid therapy. The majority of cells in the dermal infiltrate were HLA-DR positive. Keratinocytes also expressed HLA-DR antigen.AM El-Hassan, R Kubba, YM Al-Gindan, AS Omer, MK Kutty, MBM Saeed, Lymphocyte

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Section: Discussionmentioning

confidence: 58%

Intestinal Parasites: Incidence and Etiology in over 1,000 Patients at King Faisal Specialist Hospital in Riyadh

Qadri

Khalil

1987

Ann Saudi Med

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“…For example, Unanue (1972) indicated that antigen-binding dendritic cells were highly radiosensitive, a conclusion drawn from experiments which showed that irradiation could prevent antigen trapping (Williams 1966, Hanna & Hunter (1971. X-irradiation was also moderately effective in eliciting the removal of aggregated gamma globulin and other protein antigens from lymphoid follicles (Nettesheim & Hammons 1970, Jaroslow & Nossal 1966. By contrast, Schwartz et al (1978) showed that in the mouse, la*, lgT hy r adherent cells from the spleen, which were necessary for antigen presentation to syngeneic lymphoid ceils in vitro, were resistant to 900 rads.…”

Section: Antigen Localization In Immune Suppressed Animalsmentioning

confidence: 99%

The Follicular Dendritic Cell: Long Term Antigen Retention During Immunity

Mandels

Phippsi

Abbot

et al. 1980

Immunological Reviews

323

157

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“…This may result from the abolishment or elimination of a major portion of the immunocompetent T and/or B proliferative cells (Turk & Poulter 1972). In addition, the treatments may decrease or abolish the antigen processing ability of macrophages (Nettesheim & Hammons 1970). The appearance of a developing IgE and IgG antibody response in treated Hooded Lister rats between day 26 and 33, i.e., prior to booster immunization, seems to indicate that 'unprocessed' antigen, either retained within the immune system, possibly attached to antigen receptors on B cells, or remaining in the immunization depot, may stimulate subsequent generations of immunocompetent cells.…”

Section: Ige and Igg Antibody Responses In Rats Treated With Immunosumentioning

confidence: 99%

Evaluation of Basic Serum IgE Levels and the IgE Antibody Response in the Rat by Radioimmunoassays

Bennich

Ellerson

Karlsson

1978

Immunological Reviews

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Effect of Immunosuppressive Agents on Retention of Antigen in the Mouse Spleen

Cited by 20 publications

References 4 publications

Intestinal Parasites: Incidence and Etiology in over 1,000 Patients at King Faisal Specialist Hospital in Riyadh

Intestinal Parasites: Incidence and Etiology in over 1,000 Patients at King Faisal Specialist Hospital in Riyadh

The Follicular Dendritic Cell: Long Term Antigen Retention During Immunity

Evaluation of Basic Serum IgE Levels and the IgE Antibody Response in the Rat by Radioimmunoassays

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