Effect of Immunostimulatory RNA on the Fibrosis Development in Bleomycin- or LPS-Induced Mouse Models
Aleksandra V. Sen'kova,
Ali Bishani,
Innokenty A. Savin
et al.
Abstract:Previously, we described a 19-base pair double-stranded RNA with 3'-trinucleotide overhangs, acting as immunostimulatory RNA (isRNA). This molecule demonstrated notable antiproliferative effects on cancer cells, inhibited tumor growth, and elicited immunostimulatory and antiviral responses by inducing cytokine and interferon production. Within this study, we compared the efficiency of lung fibrosis development, initiated in mice by BLM or LPS using different schemes of induction. Then we compared the … Show more
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