Effect of imipramine on paradoxical sleep in animals with reference to dreaming and enuresis

Khazan, N.; Sulman, F. G.

doi:10.1007/bf00401901

Cited by 29 publications

(4 citation statements)

References 23 publications

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“…It is interesting to note that 6 children failed to wake to the alarm but one boy of 11 started waking to it when Imipramine was added. This surely lends support to the theory that Imipramine affects sleep and possibly that it works in enuresis by its effect on Rapid‐Eye‐Movement sleep (Khazan and Sulman, 1966).…”

Section: Discussionmentioning

confidence: 99%

The Treatment of Enuresis; Further Clinical Experience with Imipramine

Philpott

Flasher

1970

Int J Clinical Practice

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Section: Discussionmentioning

confidence: 99%

The Treatment of Enuresis; Further Clinical Experience with Imipramine

Philpott

Flasher

1970

Int J Clinical Practice

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“…Dozens of studies have investigated the effects of imipramine on enuresis, but its mechanism of action remains controversial and poorly understood (Rushton, 1993). Four mechanisms of action have been proposed for tricyclic antidepressants: antispasmodic and/or anticholinergic effects (H~igglund & Parkkulainen, 1964); antidepressant effects (H~igglund & Parkkulainen, 1964); alterations in arousal and sleep (Khazan & Sulman, 1966); and adrenergic neurotransmitter reuptake blockade (Fernandez de Gatta, et. al., 1990).…”

Section: Tricyclic Antidepressantsmentioning

confidence: 99%

“…Because tricyclics affect REM sleep it was proposed that they might disrupt enuretic episodes as well (Khazan & Sulman, 1966;Pierce, et. al., 1961).…”

Section: Tricyclic Antidepressantsmentioning

confidence: 99%

Current concepts in pediatric primary nocturnal enuresis

Warzak

Friman

1994

Child Adolesc Soc Work J

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It is estimated that enuresis affects 5 to 7 million children in the United States. Although the problem is common and well known, appropriate and effective treatment is not always provided. This may be due to the many etiological theories associated with this condition as well as a correspondingly high number of interventions. The present paper summarizes the empirical literature regarding primary nocturnal enuresis (PNEI, with an emphasis on pharmacological and behavioral interventions. The data support the view that children with enuresis have a wide range of negative experiences that can affect self-esteem and development, but that enuresis is not associated with significant psychiatric or behavioral difficulties. Given the strong empirical support for several interventions for PNE, children who have this condition should not go untreated.

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“…served in newborn rabbits (Khazan & Sulman, 1966) and in children (Ritvo, Ornitz, La Franchi, Walter, 1967), no direct comparison has been made between growing and adult subjects. Chlorpromazine also depressed activated sleep in adult animals Uouvet, 1962; Khazan, Kawakami, Sawyer, 1963;Hishikawa et al, 1965;Jewett & Norton, 1966;Goldstein, Cardocki, Mundschenk, O'Brien, 1967), but its effects on this sleep phase in growing animals have not been studied.…”

mentioning

confidence: 99%

Effects of psychotropic drugs on the sleep—wakefulness cycle of the developing kitten

Shimizu¹,

Himwich²

1969

Developmental Psychobiology

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[161][162][163][164][165][166][167]. T h e effccts of psychotropic drugs on the slecp-wakefulness cycle were studied in 70 kittens during their growth period from 1 to 28 days of age. Recordings of EEG, EMG of posterior neck muscles, and respiration were made as well as observations of behavior. Neither imipratnine nor chlorprotnazine decreased perccnt time of wakefulness in kittens until thcy were 16 to 18 days of agc when decreases first occurred as in mature cats. These two drugs also depressed the percent time of activated sleep and increascd that of slow-wave sleep, both actions being least prominent in newborn kittens 1 to 3 days old and becoming more marked thereafter. Propericiazine diminished activated sleep time and increased slow-wave sleep time, these changes being least marked in newborn kittens. This is thc only drug that did not decrease the percent time of wakefulness. Haloperidol is the only drug that did not dini.inish activated sleep time; slow-wave sleep time, however, was increased and the perecent time of wakefulness decreased. These effects were not obscrved until 16 to 18 days of age. I n general, for all drugs studied, the effects were less marked in the younger subjects. Morcover, the drug effects on activated sleep were established earlier than those on wakefulness. developing brain kitten sleep-wakefulness cycle chlorpromazine propericiazinc haloperidol imipramine THE INCREASED USE of psychotropic drugs in child psychiatry has stimulated studies to investigate the differences in their actions in children and adults.

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Effect of imipramine on paradoxical sleep in animals with reference to dreaming and enuresis

Cited by 29 publications

References 23 publications

The Treatment of Enuresis; Further Clinical Experience with Imipramine

The Treatment of Enuresis; Further Clinical Experience with Imipramine

Current concepts in pediatric primary nocturnal enuresis

Effects of psychotropic drugs on the sleep—wakefulness cycle of the developing kitten

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