Effect of IGF-1 and GH Genes Polymorphism on Weights and Body Measurements of Awassi Lambs in Different Ages

Abstract

The study was carried on 68 ewes of local Awassi sheep in the Al-Kafeel sheep station Karbala governorate, Iraq for the period from 1/10/2017 to 1/8/2018. Genetic analysis was carried out in the molecular genetics laboratory at the College of Agriculture / Basrah University in order to extract (DNA) and determine the genotype of the IGF-1(Insulin-like growth factor 1) and GH (Growth Hormone) genes. This study aimed to know the association between the genotype of the ewes of IGF-1 and GH genes and their relationship to the productive traits of the lambs, which included the weights of lambs from birth to weaning and body measurements, Three of the genotypes for IGF-1 were revealed AG, GC, CC and two for GH CT, TC . The effect of IGF-1 genotypes was significant (P<0.05) on weights of lambs at weaning, age 6 months and some body measurements with superior genotype GC. The genotypes of GH had a significant effect on the weight of the lambs at birth by CT superiority. While the weights of weaning, six months and body measurements were not significantly affected by different genotypes.

Polymorphisms of Palu Sheep IGF-1 Gene and Their Relationship with Skeletal Growth

“…The statistical analysis results showed the effect of IGF-1 gene genotype was insignificant on body weight and size. These results are in line with the results reported by Al Qasimi et al (2019), studying the effect of IGF-1 and GH genes on body weight and size in Awassi sheep. Gholibeikifard et al (2013) discovered no relationship between exon 3 IGF-1 polymorphism and birth, weaning, six-month, nine-month, and once-a-year weights for the Baluchi sheep.…”

Effect of Growth Hormone Exon-5 Polymorphism on Growth Traits, Body Measurements, Slaughter and Carcass Characteristics, and Meat Quality in Meat-Type Lambs in Turkey

“…The SNPs G871A, G1383A, and A1509G affected Harri sheep's LW [42]. Awassi ewes' GH gene variant affects lamb BW as well as the WH, RH, and CC between birth and weaning [43]. Furthermore, an SNP on the GH gene intron 2 region (C>A) significantly affects the LW of Santa Ines sheep on the 100th day [44].…”

Influence of single nucleotide polymorphism in the IGF-1 gene on performance and conformation traits in Munjal sheep

“…Naicy et al (2017) reported a significant association of the IGF-1 genotype with BH and chest circumference in Attappady Black goats of Kerala. Al Qasimi et al (2019) found a significant (P < 0.05) effect of IGF-1 genotypes on BH, HG and PG. Zhang et al (2008) investigated the polymorphism of the IGF-I gene and its association with growth and body size traits in Nanjiang Huang goats.…”

“…Negahdary et al (2013) reported a significant association of the IGF-1 genotype with B-WT, W-WT and 6M-WT in Makooei sheep. Al Qasimi et al (2019) found a significant (P < 0.05) effect of IGF-1 genotypes on weights of lambs at weaning and at 6 months of age with the superior genotype GC and non-significant effects on birth weight. Hajihosseinlo et al (2013) observed the significant effects of nucleotide variation in the 5 0 flanking region of the IGF-I gene with several growth traits in Makooei sheep: birth weight (BWT), weaning weight (W-WT), 6-month weight (6M-WT) and average daily gains from birth to weaning (GBW).…”