Effect of <i>Trigonella foenum graecum</i> L on the Activities of Antioxidant Enzyme and Their Expression in Tissues of Alloxan-Induced Diabetic Rats

Sharma, Sapneh; Mishra, Vibhuti; Jayant, Shiv Kumar; Srivastava, Nalini

doi:10.1177/2156587215573664

Cited by 17 publications

(9 citation statements)

References 35 publications

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“…Trigonella foenum graecum L. (fenugreek) is being used as folk medicine for diabetes treatment and several studies have demonstrated that fenugreek seed extract, mucilage of seeds and leaves have hypoglycemic effect in experimental diabetic animals and in humans [ 44 , 45 ]. A study by Sharma and coworkers [ 46 ] showed that beside hypoglycemic effect, T. foenum graecum aqueous extract increases activities and mRNA levels of SOD, GPx and CAT in the liver and the brain of alloxan-induced diabetic rats. In another study, T. foenum graecum aqueous seed extracts lowered blood glucose levels, total cholesterol, triglycerides, and increased high density lipoprotein (HDL) cholesterol in STZ-diabetic rats.…”

Section: Plants With Antidiabetic and Antioxidant Properties Modulmentioning

confidence: 99%

“… [ 42 ] Trigonella foenum graecum Aqueous extract Liver Alloxan- diabetic rats Hypoglycemic effect; increases activities and mRNA levels of SOD, GPx and CAT. [ 46 ] Aqueous extract Circulation STZ-diabetic rats Loweres blood glucose levels, total cholesterol, triglycerides and increases HDL. [ 47 ] Ixeris gracilis DC.…”

Section: Plants With Antidiabetic and Antioxidant Properties Modulmentioning

confidence: 99%

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The Influence of Plant Extracts and Phytoconstituents on Antioxidant Enzymes Activity and Gene Expression in the Prevention and Treatment of Impaired Glucose Homeostasis and Diabetes Complications

et al. 2021

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Diabetes is a complex metabolic disorder resulting either from insulin resistance or an impaired insulin secretion. Prolonged elevated blood glucose concentration, the key clinical sign of diabetes, initiates an enhancement of reactive oxygen species derived from glucose autoxidation and glycosylation of proteins. Consequently, chronic oxidative stress overwhelms cellular endogenous antioxidant defenses and leads to the acute and long-standing structural and functional changes of macromolecules resulting in impaired cellular functioning, cell death and organ dysfunction. The oxidative stress provoked chain of pathological events over time cause diabetic complications such as nephropathy, peripheral neuropathy, cardiomyopathy, retinopathy, hypertension, and liver disease. Under diabetic conditions, accompanying genome/epigenome and metabolite markers alterations may also affect glucose homeostasis, pancreatic β-cells, muscle, liver, and adipose tissue. By providing deeper genetic/epigenetic insight of direct or indirect dietary effects, nutrigenomics offers a promising opportunity to improve the quality of life of diabetic patients. Natural plant extracts, or their naturally occurring compounds, were shown to be very proficient in the prevention and treatment of different pathologies associated with oxidative stress including diabetes and its complications. Considering that food intake is one of the crucial components in diabetes’ prevalence, progression and complications, this review summarizes the effect of the major plant secondary metabolite and phytoconstituents on the antioxidant enzymes activity and gene expression under diabetic conditions.

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Section: Plants With Antidiabetic and Antioxidant Properties Modulmentioning

confidence: 99%

Section: Plants With Antidiabetic and Antioxidant Properties Modulmentioning

confidence: 99%

The Influence of Plant Extracts and Phytoconstituents on Antioxidant Enzymes Activity and Gene Expression in the Prevention and Treatment of Impaired Glucose Homeostasis and Diabetes Complications

et al. 2021

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“…Concerning the antidiabetic properties of these plants, the hypoglycemic effects of both extracts verified their ethnobotanical applications. 25,26 Aqueous extract of fenugreek seeds was capable of abolishing the elevated levels of serum malondialdehyde in a model of chronic ethanol toxicity. 27 Furthermore, the polyphenol compounds of T. foenum graecum seeds significantly decreased serum lipid peroxidation.…”

Section: Discussionmentioning

confidence: 99%

Comparison the Effects of Trigonella foenum-graecum L. Seed and Cordia myxa Fruit Extracts on DiabetesInduced Memory Impairment in Rats

nasab

Hajinezhad

Hashemi

et al. 2017

Int J Basic Sci Med

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Introduction: Trigonella foenum-graecum L. (Fenugreek) seeds and Cordia myxa fruits have been known as agents with anti-diabetes effects in Iranian traditional medicine. We compared the effects of aqueous extracts of these plants on diabetes-induced cognitive dysfunction. Methods: In our study, rats were equally allocated to 4 groups (n=12/group) as follows: control; diabetic; diabetic rats treated with T. foenum graecum seeds extract (TE) (870 mg/kg BW); and diabetic rats treated with C. myxa fruit extract (CE) (500 mg/kg BW) for 30 days. Diabetes was induced by alloxan (120 mg/kg BW, ip). Cognitive dysfunction was determined through memory task and passive avoidance learning (PAL). Results: Diabetes resulted in cognitive impairment in PAL and memory task. CE and TE significantly reduced serum blood sugar (P<0.05) and brain lipid peroxidation (P<0.001). Moreover, treatment with both extracts prohibited learning and memory deficits in diabetic groups in comparison to the non-treated group; however, there was no significant difference between the groups that were treated with TE or CE. Conclusion: Aqueous extract of fenugreek seeds and C. myxa are effective in preventing diabetesinduced lipid peroxidation and memory loss in animal models of diabetes.

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“…31 The decreased activity of SOD and CAT could also be due to their decreased protein expression levels in the diabetic condition as reported recently in liver. 32 However, the activity of GPx and GR are enhanced in the diabetic rat brains. The result is consistent with the studies of Ulusu et al which suggest that the increased GPx and GR activity represents compensatory mechanism to degrade H 2 O 2 , which are produced in excess during the metabolism of catecholamines.…”

Section: Effect On Lipid Peroxidation Levelmentioning

confidence: 97%

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2015

IJPSR

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The present study evaluates antidiabetic effect of A. indica leaf extract (AILE) and A. indica bark extract (AIBE) on antioxidant enzymes in the brain of alloxan diabetic rats and compared with insulin treatment. The oral effective dose of A. indica leaf (500mg/Kg body weight) and A. indica bark (100mg/Kg body weight) was given once daily for 21days to separate groups of diabetic rats. At the end of the experimental period, blood glucose levels and activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and glucose-6-phosphate dehydrogenase (G-6-PD) were measured in cytosolic fraction of whole brain. Lipid peroxidation levels were measured in the blood plasma and brain of all the treated diabetic groups. Diabetic rats showed high blood glucose (p<0.01). Decreased activities of SOD, CAT, G-6-PD (p<0.05) and increased activity of GPx, GR were observed in diabetic rats brain. Diabetic controls showed significant increase in MDA level in brain tissue (p<0.05). Treatment with insulin, AILE and AIBE restored the above altered parameters close to the control ones. AILE and AIBE were found significantly effective in correcting these alterations INTRODUCTION: Diabetes is characterized by hyperglycemia and metabolic abnormalities due to decreased insulin levels, causing metabolic and physiological changes in various organs including brain. 1, 2 Oxidative stress is suggested to be a potential contributor to the development of complications in diabetes. 3-6 High oxidative stress can lead to microvascular cerebral diseases, including stroke, cerebral hemorrhage and brain infarction. 7, 8

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Effect of Trigonella foenum graecum L on the Activities of Antioxidant Enzyme and Their Expression in Tissues of Alloxan-Induced Diabetic Rats

Cited by 17 publications

References 35 publications

The Influence of Plant Extracts and Phytoconstituents on Antioxidant Enzymes Activity and Gene Expression in the Prevention and Treatment of Impaired Glucose Homeostasis and Diabetes Complications

The Influence of Plant Extracts and Phytoconstituents on Antioxidant Enzymes Activity and Gene Expression in the Prevention and Treatment of Impaired Glucose Homeostasis and Diabetes Complications

Comparison the Effects of Trigonella foenum-graecum L. Seed and Cordia myxa Fruit Extracts on DiabetesInduced Memory Impairment in Rats

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