Effect of<i>Sasa quelpaertensis</i>Nakai Extracts and its Constituent<i>p</i>-coumaric Acid on the Apoptosis of Human Cancer Cell Lines

Jang, Mi; Ko, Hee-Chul; Kim, Se Jae

doi:10.20307/nps.2018.24.4.293

Cited by 7 publications

(8 citation statements)

References 17 publications

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“…PARP is cleaved by caspase-3, which causes apoptosis (32,34). our findings are therefore consistent with other reports that S. quelpaertensis Nakai triggers apoptosis in human leukemia HL-60 (16,17) and gastric cancer MKN-74 (17) cells by up-regulation of Bax, caspase 3 and PARP as well as down-regulation of anti-apoptotic proteins such as survivin and Bcl-2.…”

Section: Discussionsupporting

confidence: 92%

“…The ethanol extracts of S. quelpaertensis Nakai contained a larger quantity of phenolics and flavonoids (2.1-and 4.6-fold, respectively) and exhibited stronger radical scavenging, ferrous chelating and reducing power abilities, and an anti-proliferative effect on HCT116 colon cancer cells when compared to water extracts (23). In addition, other studies revealed that S. quelpaertensis Nakai extracts showed antiproliferation and apoptosis induction properties in human leukemia HL-60 cells (17), as well as in human and lung cancer A549 and H1299 cells. Despite previous reports demonstrated that potential clinical application of dwarf bamboo S. quelpaertensis Nakai extracts for prevention or treatment of neoplastic disease (19,23,24), the underlying mechanism has not been clarified.…”

Section: Discussionmentioning

confidence: 97%

“…Like other bamboo species, S. quelpaertensis Nakai has been used in herbal medicine like other bamboo species for various pharmacological properties such as antioxidant (7)(8)(9), anticancer (10,11), antidiabetic (12), inhibition of tyrosinase and melanin production (13), hepatoprotective (9,14) and anti-inflammatory (15) properties. Recently, S. quelpaertensis Nakai has earn commercial attention for its ability to prohibit human leukemia HL-60 cells (16,17), gastric adenocarcinoma MKN-74 (17), colon cancer HT-29 (18) cells proliferation by inducing apoptosis. In those study, an excessive and unregulated nitric oxide (NO • ) synthesis has been implicated to abrogation of tumorigenicity and induction of apoptosis in tumor cells (18,19).…”

Section: Introductionmentioning

confidence: 99%

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Sasa�quelpaertensis Nakai extract induces p53‑independent apoptosis via the elevation of nitric oxide production in human HCT116 colon cancer cells

Kim

2020

Oncol Lett

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Induction of apoptosis in human cancer cells by Sasa quelpaertensis Nakai has been considered to be a potential therapeutic target for cancer treatment; however, the underlying mechanisms of action are not well understood. The present study investigated the role of nitric oxide (NO • ) and inhibitors of apoptosis (IAPs) during apoptosis induced by Sasa quelpaertensis Nakai extracts (SQE) in p53-wild type (WT) and p53-null HCT116 colon carcinoma cells. Trypan blue exclusion and Annexin V/propidium iodide assays were used to test for antiproliferation, and apoptosis and cell cycle. Griess and reverse transcription-polymerase chain reaction and western blotting assays were carried out to assay NO • production, and to detect the mRNA and protein levels of Bcl-2, PARP and IAPs. A colorimetric assay was utilized to measure the time-dependent increase in caspase-3 activity. SQE inhibited cell growth and promoted apoptosis by the elevation of NO • in a dose-and time-dependent manner. In addition, both cell types underwent a reduction in mRNA and protein levels of IAPs (survivin, CIAP-1 and -2, and X-linked inhibitor of apoptosis) as well as anti-apoptotic Bcl-2, whereas an increase in protein expression of poly (ADP-ribose) polymerase 1 and caspase 3 activity was observed; however, an equivalent cytotoxic and apoptotic effect by SQE was observed in p53-WT and p53-null cells. Collectively, the results indicated that SQE-induced apoptosis was independent of p53 status and associated with modulation of endogenous NO • and IAP family gene expression.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Sasa�quelpaertensis Nakai extract induces p53‑independent apoptosis via the elevation of nitric oxide production in human HCT116 colon cancer cells

Kim

2020

Oncol Lett

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“…The western blotting analysis protocol of Jang et al [29] with slight adjustments was applied to detect expression of proteins-modulated apoptosis. MCF-7 cells (4 × 10 5 cells/well) were seeded on 6-well plates and incubated for 24 h at 37 • C in a humid atmosphere with 5% CO 2 .…”

Section: Western Blottingmentioning

confidence: 99%

Analysis and Anticancer Effects of Active Compounds from Spatholobi Caulis in Human Breast Cancer Cells

Phung

Lee

et al. 2020

Processes

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Breast cancer is the most common malignancy in both developing and developed countries. In this study, we simultaneously analyzed nine constituent compounds from Spatholobi Caulis (gallic acid, (−)-gallocatechin, 3,4-dihydroxybenzoic acid, procyanidin B1, 3,4-dihydroxybenzaldehyde, catechin, procyanidin B2, epicatechin, and (−)-epicatechin gallate) and examined their anticancer effects on MCF-7 and MDA-MB-231 human breast cancer cells. The experimental results indicated that the gallic acid showed the strongest cytotoxic effect on MCF-7 cells among tested compounds whilst most of samples did not express inhibitory effect on viability of MDA-MB-231 cells, except for 70% ethanol extract of S. Caulis. Thus, gallic acid was chosen to extend anticancer mechanism study on MCF-7 cells. Our data showed that the gallic acid induced apoptotic MCF-7 cell death through both extrinsic and intrinsic pathways, which increased the expression of cleaved caspase-7, -8, and -9, Bax and p53, but reduced the expression of Bcl-2 and poly (ADP-ribose) polymerase (PARP). In addition, the network pharmacological analysis pointed out that the p53, mitogen-activated protein kinase (MAPK), estrogen, and Wnt signaling pathways have a great correlation with the targets of gallic acid. This study suggested that gallic acid is a bioactive component of S. Caulis with potential to be used in chemotherapy for breast cancer.

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“…The biological activity of coumaric acid has been reported in recent years [14]. P-Coumaric acid shows antidiabetic activity [15], antioxidant activity [16], antitumor activity [17]. p-Coumaric acid protect neurons against injury induced by 5-S-cysteinyl-dopamine [18], alleviate of the intestinal Ischemia/Reperfusion injury [19].…”

Section: Biological Activitymentioning

confidence: 99%

p-COUMARATES OF BETULA PENDULA (BETULACEAE) VEGETATIVE BUDS SESQUITERPENE ALCOHOLS

Vedernikov

Ipanova

2020

JCPRM

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The composition of coumarates sesquiterpene alcohols of Betula pendula Roth. birch vegetative buds was determined. Fraction was isolated from buds extract by preparative liquid chromatography. The extract was isolated by sequential extraction of an alcoholic extract of the buds with methyl tert-butyl ether. The new sesquiterpene derivatives were first detected in the birch vegetative buds. The structure of 6-hydroxyisocaryophyllene [(1R,4Z,6R,9S)-8-methylene-11,11-dimethylbicyclo[7.2.0]undec-4-ene-6-ol] trans-p-coumarate isolated from the birch buds was determined by NMR spectroscopy. The physico-chemical characteristics and NMR data of 6-hydroxyisocaryophyllene p-coumarate and others coumarates are demonstrated. The gas chromatographic retention indices of all identified compounds were determined. Birch buds contain derivatives of trans-coumaric acid. The antimicrobial activity of sesquiterpene alcohols coumarates was evaluated. The antimicrobial activity of sesquiterpene alcohols coumarates in relation to the following microorganisms: Escherichia coli, Proteus mirabilis, Staphylococcus aureus, Staphylococcus pneumonia and Klebsiella pneumonia was evaluated. The fraction of sesquiterpene alcohols coumarates showed activity against Staphylococcus epidermidis.

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Effect ofSasa quelpaertensisNakai Extracts and its Constituentp-coumaric Acid on the Apoptosis of Human Cancer Cell Lines

Cited by 7 publications

References 17 publications

Sasa�quelpaertensis Nakai extract induces p53‑independent apoptosis via the elevation of nitric oxide production in human HCT116 colon cancer cells

Sasa�quelpaertensis Nakai extract induces p53‑independent apoptosis via the elevation of nitric oxide production in human HCT116 colon cancer cells

Analysis and Anticancer Effects of Active Compounds from Spatholobi Caulis in Human Breast Cancer Cells

p-COUMARATES OF BETULA PENDULA (BETULACEAE) VEGETATIVE BUDS SESQUITERPENE ALCOHOLS

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