Effect of <i>Saraca asoca</i> (Asoka) on estradiol-induced keratinizing metaplasia in rat uterus

Shahid, Adangam Purath; Salini, Sasidharan; Sasidharan, N.; Padikkala, José; Raghavamenon, Achuthan C.; Babu, T. Ramesh

doi:10.1515/jbcpp-2014-0124

Cited by 14 publications

(13 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Keratinization in uterus of all the rats was induced by the i. p. injection of 20 μg/kg b. wt. estradiol in 0.05 ml of propanediol for 5 alternative days 22 except first and second groups of animals, which was kept as normal and vehicle control receiving propanediol, respectively. Among these, the animals of third group were kept as control without drug treatment.…”

Section: Methodsmentioning

confidence: 99%

Kingiodendron pinnatum , a pharmacologically effective alternative for Saraca asoca in an Ayurvedic preparation, Asokarishta

Shahid

Sasidharan

Salini

et al. 2018

Journal of Traditional and Complementary Medicine

Self Cite

View full text Add to dashboard Cite

Saraca asoca (Fabaceae) is a prime ingredient in Asokarishta, a well-known Ayurvedic preparation for gynecological ailments. Due to scarcity, adulteration or substitution of related raw drugs is a common practice in its preparation. The bark of Kingiodendron pinnatum (Roxb. ex DC.) Harms, morphologically similar to S. asoca (Asoka) is a widely used substitute. The present study aimed to evaluate the pharmacological effectiveness of K. pinnatum as an alternative for S. asoca in Asokarishta by determining the inhibitory effect of estrogen induced uterus endometrial thickening in immature female rats. Arishta was prepared using S. asoca and with the substitute, K. pinnatum as per Ayurvedic Pharmacopeia. Uterus endometrial thickening was induced by the administration of estradiol (20 μg/kg b. wt, i.p) to 8-day-old rats for 5 alternate days. On day 16, following estradiol administration, the serum estrogen level was found elevated to 156.5 ± 8 pg/ml from the normal value 32.4 ± 5 pg/ml and consequently increased the thickness of uterus endometrium from 16.7 ± 1.4 to 75.2 ± 15.3 μm. Upon oral administration of 400 μl/kg b. wt Asokarishta (ASA) and Arishta made with K. pinnatum (AKP), the thickening was reduced to 42.5 ± 12.7 and 47.1 ± 10.5 μm and the estrogen level diminished to 102.6 ± 10 and 97.3 ± 8 pg/ml, respectively. Arishta also reduced the chronic/acute inflammations in mice and improved the antioxidant status of rats. No toxic symptom was observed in the animals by the treatment of Arishta. The study supports the use of K. pinnatum as an alternative to S. asoca in Asokarishta and gives a scientific validation for Asokarishta in gynecological ailments.

show abstract

Section: Methodsmentioning

confidence: 99%

Kingiodendron pinnatum , a pharmacologically effective alternative for Saraca asoca in an Ayurvedic preparation, Asokarishta

Shahid

Sasidharan

Salini

et al. 2018

Journal of Traditional and Complementary Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…It reacts on the ovarian tissue and also its action resembles as estrogen and stimulates the normal functionality of uterus thus it arrests bleeding [12].…”

Section: Siddha Elixir: a Natural Waymentioning

confidence: 99%

Siddha Elixir and Aeitology of Polycystic Ovarian Syndrome

My¹,

Suresh²,

K³

2017

Adv Tech Biol Med

View full text Add to dashboard Cite

Siddha medicine is a treatment which is followed by an Ancient Tamilians. It has no side effects and cost efficient. Polycystic ovarian syndrome is a hormonal disorder affecting many women nowadays. It is called as syndrome because it shows many symptoms. It is also named as polycystic ovary disease, stein Leventhal syndrome or hyper androgen anovulation syndrome. In this PCOS more than 12 tiny cysts present in the ovary. It may cause due to genetic problem or lifestyle factors. This review interrupts the solution to reduce the risk and ill effects of PCOS with help of siddha medicine which is the best, nil side effects, and cheapest medicinal system.

show abstract

“…The stem bark of this plant is used for the treatment of menstrual disorders in India (Bhandary, Chandrashekar, & Kaveriappa, ). Additionally, it possess antioxytocic activity (Satyavati, Prasad, Sen, & Das, ), acts as uterine tonic (Shahid et al., ) and has anti‐estrogenic activity as well (Shahid et al., ). Stem Bark of S. asoca contains (−)‐gallocatechin, catechin, +(−)‐epigallocatechin, (−)‐epigallocatechingallate, (+)‐afzelechin‐3‐O‐l‐rhamnopyranoside, (+)‐epiafzelechin‐3‐O‐d‐glucopyranoside, (−)‐epicatechin, (−)‐gallocatechingallate, (−)‐catechingallate, epicatechingallate, 5,3′‐dimethoxy‐(−)‐epicatechin, leucocyanidin and leucopelargonidin.…”

Section: Introductionmentioning

confidence: 99%

Chemically characterised extract ofSaraca asocaimproves the sexual function in male Wistar rats

et al. 2018

View full text Add to dashboard Cite

In this study, methanolic extract of Saraca asoca bark was evaluated for its aphrodisiac potential using male and female Wistar albino rats. Male rats were dosed daily for 54 days at a dose of 100 mg/kg p.o. Sexual activity of male rats was assessed after 14, 28, 42 and 54 days of the study. Male rats were placed in a glass chamber lit with a dim red light (10W) followed by the introduction of sexually receptive female rats in a ratio of 1:1. Improvement in sexual behaviour of male rats was characterised by an increase in both mount frequency and intromission frequency and decrease or reduction in mount latency and intromission latency compared to normal control. After completion of the study, the effect of the S. asoca extract on sperm count, sperm motility and sperm morphology was also assessed. The extract of S. asoca bark was found to be safe as it did not affect these sperm parameters. From this study, it was found that methanolic extract of S. asoca bark plays a role in enhancing sexual behaviour and potential without causing reproductive toxicity.

show abstract

Effect of Saraca asoca (Asoka) on estradiol-induced keratinizing metaplasia in rat uterus

Abstract: Present study reveals the antiproliferative and antikeratinizing effects of S. asoca in uterus endometrium possibly through its anti-estrogenic and anti-inflammatory properties.

Cited by 14 publications

References 11 publications

Kingiodendron pinnatum , a pharmacologically effective alternative for Saraca asoca in an Ayurvedic preparation, Asokarishta

Kingiodendron pinnatum , a pharmacologically effective alternative for Saraca asoca in an Ayurvedic preparation, Asokarishta

Siddha Elixir and Aeitology of Polycystic Ovarian Syndrome

Chemically characterised extract ofSaraca asocaimproves the sexual function in male Wistar rats

Contact Info

Product

Resources

About