Effect of <i>Rhus coriaria</i> L. methanolic fruit extract on wound healing in diabetic and non‐diabetic rats

Alsarayreh, Ahmad Za’al; Oran, Sawsan A.; Shakhanbeh, Jumah

doi:10.1111/jocd.14668

Cited by 9 publications

(11 citation statements)

References 47 publications

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“…Under stress conditions, such as the administration of corticosteroids, the physiological ability of epidermis cells to repair damage induced by abrasions or wounds was impaired. RC-P showed the best activity under these conditions by stimulating keratinocytes to close the wound both after 6 and 24 h. The efficacy of RC-P in a model of reduced wound healing is consistent with the increased wound contraction observed by Alsarayreh and co-authors using a methanolic extract of R. coriaria fruits in diabetic and non-diabetic rats, which was related to the reduction of IL-6 and the increase of IL-10, hydroxyproline and collagen expression [32]. The activity of RC-P on the fibroblast component of epidermis has proved to be as effective as on keratinocytes but only after 24 h of treatment in both basal and stress conditions.…”

Section: Discussionsupporting

confidence: 85%

In Vitro Cell Culture of Rhus coriaria L.: A Standardized Phytocomplex Rich of Gallic Acid Derivatives with Antioxidant and Skin Repair Activity

Pressi¹,

Bertaiola²,

Guarnerio³

et al. 2022

Cosmetics

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This study focused on the biological evaluation and chemical characterization of a new ingredient obtained by in vitro cell culture of Rhus coriaria L. An in vitro plant cell culture method permits to cultivate plant in a short period of time and to obtain extract with a high safety profile for the consumer, free from heavy metals, pesticides, aflatoxins, bacterial or fungal contamination. Through the selection of specific cell culture media, it was possible to obtain a Rhus coriaria cell line with a high content of gallic acid derivatives. The Rhus coriaria L. phytocomplex (RC-P), containing 7.6% w/w of acid gallic derivatives, was obtained by drying of plant cell biomass after 14 days of growth in the final selected culture medium. UPLC-ESI-MS and UPLC-DAD analysis allowed to identify numerous gallic acid derivatives, such as galloyl hexose, trigalloyl hexose and high molecular weight galloyl derivatives, and to quantify their overall content. The antioxidant activity of the RC-P was tested by DPPH assay and the wound healing activity was evaluated using a scratch wound healing test on human keratinocytes and fibroblasts. This work showed that RC-P could be a new effective cosmetic ingredient with antioxidant and skin repair activity.

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Section: Discussionsupporting

confidence: 85%

In Vitro Cell Culture of Rhus coriaria L.: A Standardized Phytocomplex Rich of Gallic Acid Derivatives with Antioxidant and Skin Repair Activity

Pressi¹,

Bertaiola²,

Guarnerio³

et al. 2022

Cosmetics

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show abstract

“…After 4 weeks of treatment, blood samples were taken to evaluate the lipid profile, liver, and kidney functions. On the same day, the rats were anesthetized under general anesthesia induced by diethyl ether inhalation as described by Alsarayreh et al [ 23 ], and their organs, including liver, spleen, pancreas, and kidney, were collected and preserved in phosphate-buffered saline (PBS) (pH 7.4) at −80 °C for further use. The body weight of all rats was recorded on Day 1 and thereafter once weekly.…”

Section: Methodsmentioning

confidence: 99%

Antioxidant and Antihyperglycemic Effects of Ephedra foeminea Aqueous Extract in Streptozotocin-Induced Diabetic Rats

et al. 2022

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Background: Ephedra foeminea is known in Jordan as Alanda and traditionally. It is used to treat respiratory symptoms such as asthma and skin rashes as an infusion in boiling water. The purpose of this study was to determine the antidiabetic property of Ephedra foeminea aqueous extract in streptozotocin-induced diabetic rats. Methods: The aqueous extract of Ephedra foeminea plant was used to determine the potential of its efficacy in the treatment of diabetes, and this extract was tested on diabetic rats as a model. The chemical composition of Ephedra foeminea aqueous extract was determined using liquid chromatography–mass spectrometry (LC-MS). Antioxidant activity was assessed using two classical assays (ABTS and DPPH). Results: The most abundant compounds in the Ephedra foeminea extract were limonene (6.3%), kaempferol (6.2%), stearic acid (5.9%), β-sitosterol (5.5%), thiamine (4.1%), riboflavin (3.1%), naringenin (2.8%), kaempferol-3-rhamnoside (2.3%), quercetin (2.2%), and ferulic acid (2.0%). The antioxidant activity of Ephedra foeminea aqueous extract was remarkable, as evidenced by radical scavenging capacities of 12.28 mg Trolox/g in ABTS and 72.8 mg GAE/g in DPPH. In comparison to control, induced diabetic rats treated with Ephedra foeminea extract showed significant improvement in blood glucose levels, lipid profile, liver, and kidney functions. Interleukin 1 and glutathione peroxidase levels in the spleen, pancreas, kidney, and liver of induced diabetic rats treated with Ephedra foeminea extract were significantly lower than in untreated diabetic rats. Conclusions: Ephedra foeminea aqueous extract appears to protect diabetic rats against oxidative stress and improve blood parameters. In addition, it has antioxidant properties that might be very beneficial medicinally.

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“…Biochemical tests were also done on the serum. The doses of plant extracts given were chosen based on a previously reported LD 50 in rats ( R. coriaria fruit extract of more than 1975 mg/kg body weight [ 27 ], G. arabica was up to 1000 mg/kg wt [ 28 ], and M. sylvestris was up to 2000 mg/kg wt [ 29 ]).…”

Section: Methodsmentioning

confidence: 99%

“…Diethyl ether was inhaled to anesthetize rats. The dorsal aspect was shaved with an electrical clipper (Geemy professional hair clipper), and the skin was removed with a 10 mm biopsy needle (Disposable Biopsy Punch, ROBBINS Instrument, Mutah University) Figure (2) [ 27 ]. Contraction, which is primarily responsible for wound closure, was investigated until the wounds were completely epithelized.…”

Section: Methodsmentioning

confidence: 99%

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Efficacy of methanolic extracts of some medicinal plants on wound healing in diabetic rats

Alsarayreh

Oran

Shakhanbeh

et al. 2022

Heliyon

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Effect of Rhus coriaria L. methanolic fruit extract on wound healing in diabetic and non‐diabetic rats

Cited by 9 publications

References 47 publications

In Vitro Cell Culture of Rhus coriaria L.: A Standardized Phytocomplex Rich of Gallic Acid Derivatives with Antioxidant and Skin Repair Activity

In Vitro Cell Culture of Rhus coriaria L.: A Standardized Phytocomplex Rich of Gallic Acid Derivatives with Antioxidant and Skin Repair Activity

Antioxidant and Antihyperglycemic Effects of Ephedra foeminea Aqueous Extract in Streptozotocin-Induced Diabetic Rats

Efficacy of methanolic extracts of some medicinal plants on wound healing in diabetic rats

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