Effect ofOcimum sanctumLinn. (Tulsi) extract on the immunity and survival ofLabeo rohita(Hamilton) infected withAeromonas hydrophila

Das, Rakesh; Raman, Rajagopalan; Saha, Himadri; Singh, Ranjan K.

doi:10.1111/are.12264

Cited by 68 publications

(55 citation statements)

References 37 publications

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“…The herbal component of E Care Se Herbal, O. sanctum, revealed immunostimulating properties by virtue of increasing heterophils and lymphocyte count, enhancing phagocytic activity and phagocytic index and reducing total bacterial count. Oil from Tulsi seed can mediate GABAergic pathways and by this it can modulate both humoral and cell-mediated immunity [23]. The present study correlates with the above point in case of Values with different superscript along a row differ significantly…”

supporting

confidence: 87%

Immunomodulatory and prophylactic efficacy of herbal extracts against experimentally induced chicken infectious anaemia in chicks: assessing the viral load and cell mediated immunity

et al. 2017

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Chicken infectious anaemia virus (CIAV) is an economically important and a highly immunosuppressive virus affecting poultry industry worldwide. In this study we assessed the immunomodulatory effects of four herbal preparations namely Withania somnifera, Tinospora cordifolia, Azadirachta indica and E Care Se Herbal in resisting the viral multiplication and immunosuppression inflicted by CIAV in chicks. Day-old chicks (n = 90) were randomly and equally divided into six groups (Groups A-F). Groups A-D were administered with purified extracts of W. somnifera, T. cordifolia, A. indica and E Care Se Herbal, respectively followed by the evaluation of viral load in lymphoid organs by quantitative real-time PCR and cell mediated immune response by flow cytometric analysis of CD4 ? and CD8 ? T cells. Groups A-D were found to resist CIAV multiplication and pathogenesis with significant reduction of viral load compared with the infected control (P \ 0.05). Group A-C chicks showed significantly higher (P \ 0.05) CD4 ? and CD8 ? T cell counts compared to control birds while of E Care Se Herb had minimal effect on T cell count. The findings suggested that the herbal preparations used during the study were effective as both prophylactic and immunomodulatory agents and thus have potential of being used against CIAV induced immunosuppression in poultry.

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confidence: 87%

Immunomodulatory and prophylactic efficacy of herbal extracts against experimentally induced chicken infectious anaemia in chicks: assessing the viral load and cell mediated immunity

et al. 2017

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“…Feeding of holy basil at the concentration of 100 and 200 mg/kg of diet also significantly reduced the mortality from V. harveyi than control in greasy grouper (Sivaram et al, 2004). Moreover, dietary holy basil extract of 0.2% showed significantly higher protection relative percentage survival of Labeo rohita against A. hydrophila infection than control (Das et al, 2013).…”

Section: Discussionmentioning

confidence: 86%

“…The leaves of holy basil contain water-soluble phenolic compounds and various components, such as eugenol, methyl eugenol and caryophyllene that act as immunostimulants (Bairwa et al, 2012). In aquaculture, the supplementation of feed with holy basil extract was studied in several fish, including Oreochromis mossambicus (Logambal et al, 2000), Epinephelus tauvina (Sivaram et al, 2004), Catla catla (Chitra and Krishnaveni, 2011), Cyprinus carpio (Pavaraj et al, 2011) and Labeo rohita (Das et al, 2013). Moreover, holy basil also affects the resistance to pathogens, such as Vibrio harveyi (Sivaram et al, 2004) and Aeromonas hydrophila (Logambal et al, 2000;Chitra and Krishnaveni, 2011;Pavaraj et al, 2011;Das et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Effects of Holy Basil (Ocimum sanctum) Extract on the Growth, Immune Response and Disease Resistance against Streptococcus agalactiae of Nile Tilapia (Oreochromis niloticus)

Panprommin¹,

Kaewpunnin²,

Insee³

2016

IJAB

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This study was conducted to investigate the effects of supplementing the diet of Nile tilapia (Oreochromis niloticus) with holy basil (Ocimum sanctum) extract at the concentrations of 0 (control), 100, 200 and 400 mg/kg of feed for 30 days. The treated fish fed the holy basil extract at the 200 mg/kg level showed the significantly (P<0.05) greatest increases in specific growth rate and the greatest improvements in feed conversion ratio. The immune response, phagocytic activity and superoxide anion production were also stimulated the most on day 7 of the feed supplementation. In a streptococcal challenge experiment, the fish fed the holy basil extract at the 100 and 200 mg/kg levels showed 0% cumulative mortality, whereas the control group and the fish fed with extract at the 400 mg/kg level showed 100 and 40% mortality, respectively. The greatest stimulation of the immune response occurred in the fish fed the holy basil extract at the level of 200 mg/kg of diet. Thus, the analysis of the relative expression levels of three cytokine genes, which included interleukin-1β (IL-1β), interleukin-8 (IL-8) and transforming growth factor-β (TGF-β), were compared between a control group and a fish group fed the holy basil extract at the 200 mg/kg level. The expression of all the genes was significantly (P<0.05) greater in the treated than in the control fish, especially on day 7 of the feed supplementation. These results indicated that the addition of holy basil extract to fish feed at the rate of 200 mg/kg of diet could enhance the growth, immune response and disease resistance against S. agalactiae of Nile tilapia during a 30-day supplementation period.

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“…It has proved to be an effective means of increasing immunopotency of fish. So far, a large number of immunostimulants, that include a very heterogenous group of substances like synthetic chemicals, biological substances, mycelial fungi, killed mycobacterium, polysaccharides, glucans, peptidoglycan, [125] peptides, muramyl dipeptide, nutritional factors, hormones, cytokinins, and animal and plant extracts/ingredients like Azadirachtin, Piperine, Curcumin, Ocimum sanctum, Aloe vera extracts etc have been tested on the immune response in a variety of finfish and shellfish species [142] [143] [144]. However, the knowledge on the use of plant extracts and herbal medicines as immunostimulants is in its infancy, even though such botanical products are a rich source of active substances for immunotherapy [145].…”

Section: As Immunostimulantmentioning

confidence: 99%

Applicability, Feasibility and Efficacy of Phytotherapy in Aquatic Animal Health Management

Raman¹

2017

AJPS

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The use of chemotherapeutants, antibiotics, and pesticides in aqua farms and non-adherence to scientific management practices have resulted in adverse impact on aquacultural production, serious outbreaks of diseases, development of drug resistance in microbes, and accumulation of antibiotics and pesticide residues in finfish and shellfish and environmental pollution. As a result, a need has been felt by the aquaculturists as well as aquatic animal health management professionals to find a suitable alternative therapy in place of antibiotics and chemotherapy. Phytotherapy has come to be recognized as a handy and viable alternative to chemotherapy, as it is economical, effective, non-resistance forming, renewable, eco-friendly and farmer-friendly. Although the use of medicinal plants is known to humanity since the dawn of human civilization for the treatment and control of human and animal diseases but its importance in combating finfish and shellfish diseases has been realized only recently. The phytotherapy of aquacultural diseases is in its infancy in most part of the world except in China to some extent. However, many important contributions in this field by different workers during the last quarter of the 20 th century and early 21 st century have shown encouraging results and opened new vistas in phytotherapy of aquatic animals. The present review crtically evaluates the present status of knowledge of phytotherapy in the world combating various aquacultural diseases, identifying the bottlenecks and suggests remedial measures.

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Effect ofOcimum sanctumLinn. (Tulsi) extract on the immunity and survival ofLabeo rohita(Hamilton) infected withAeromonas hydrophila

Cited by 68 publications

References 37 publications

Immunomodulatory and prophylactic efficacy of herbal extracts against experimentally induced chicken infectious anaemia in chicks: assessing the viral load and cell mediated immunity

Immunomodulatory and prophylactic efficacy of herbal extracts against experimentally induced chicken infectious anaemia in chicks: assessing the viral load and cell mediated immunity

Effects of Holy Basil (Ocimum sanctum) Extract on the Growth, Immune Response and Disease Resistance against Streptococcus agalactiae of Nile Tilapia (Oreochromis niloticus)

Applicability, Feasibility and Efficacy of Phytotherapy in Aquatic Animal Health Management

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