Effect of <i>Nigella sativa</i> on Glucose Concentration, Lipid Peroxidation, Anti‐Oxidant Defence System and Liver Damage in Experimentally‐Induced Diabetic Rabbits

Meral, İsmail; Yener, Zabit; Kahraman, Tahir; Mert, Nihat

doi:10.1046/j.1439-0442.2001.00393.x

Cited by 167 publications

(126 citation statements)

References 20 publications

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“…Recently, many therapeutic effects of NS extracts have been documented, including antioxidant (Burits and Bucar, 2000;Balikci, 2010), antimicrobial, antihelmintic (Agarwal et al, 1979), anti-inflammatory (Houghton et al, 1995), anti-tumour (Worthen et al, 1998), anti-diabetic (Meral et al, 2001) and antiulcerogenic (Akhtar et al, 1996) effects in both clinical and experimental studies. With this study we aimed at comparatively analyzing the effects of NS and SSD on wound healing in a burn wound model.…”

Section: Discussionmentioning

confidence: 99%

Effects of Nigella sativa and silver sulfadiazine on burn wound healing in rats

Yaman¹,

Durmuş²,

Çeribaşi³

et al. 2010

Vet. Med.

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This experiment was conducted in order to compare the effects of Nigella sativa (NS) and silver sulfadiazine (SSD) cream on healing of burn wounds in rats. Fifty four adult, male Wistar-albino rats were divided into three groups of equal numbers. A burn was generated on the backs of all the rats. The burned areas in the first, second and third groups were covered with daily cold cream (control), SSD cream and NS cream (50% NS oil + 50% cold cream), respectively. Four, nine, and 14 days later, the rats were sacrificed and the burned skin tissue samples were collected for histopathological examinations. Histopatological evaluations on the 4 th , 9 th and 14 th days showed burn healing to be better in the NS and SSD groups with respect to the control group. Wound healing was significantly different among the groups at 4 th , 9 th and 14 th days (P < 0.001). In conclusion, application of NS and SSD cream are effective in healing burn related skin wounds in the rat model.

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Section: Discussionmentioning

confidence: 99%

Effects of Nigella sativa and silver sulfadiazine on burn wound healing in rats

Yaman¹,

Durmuş²,

Çeribaşi³

et al. 2010

Vet. Med.

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“…Meral et al induced diabetes in rabbits using 150 mg/ kg of 10% alloxan. Oral N. sativa treatment for 2 months in these rabbits, decreased the elevated glucose and malondialdehyde (MDA) concentrations, increased the lowered glutathione (GSH) and ceruloplasmin concentrations, and prevented lipid-peroxidation-induced liver damage in diabetic rabbits [59]. Anti-diabetic action of N. sativa is at least partly mediated through decreased liver gluconeogenesis [60].…”

Section: Possible Mechanisms Of Antidiabetic Activitymentioning

confidence: 99%

Antidiabetic Properties of a Spice Plant Nigella sativa

Mathur

2011

J Endocrinol Metab

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Seeds of Nigella sativa (black cumin/kalonji) used in pickles as spice, have also been traditionally used in treatment of many diseases including diabetes and hypertension. Among many activities exhibited by N. sativa and its constituents in animal experiments, antidiabetic property is most important. Thymoquinone (TQ), a volatile oil, is one of its active constituents but antidiabetic activity has also been shown by its aqueous extract and defatted extract. N. sativa may be beneficial in diabetic individuals and those with glucose intolerance as it reduces appetite, glucose absorption in intestine, hepatic gluconeogenesis, blood glucose level, cholesterol, triglycerides, body weight and simulates glucose induced secretion of insulin from beta-cells in pancreas; improves glucose tolerance as efficiently as metformin; yet it has not shown significant adverse effects and has very low toxicity. In streptozotocin (STZ) induced diabetic rats it causes gradual partial regeneration of pancreatic beta-cells, increases the lowered serum insulin concentrations and decreases the elevated serum glucose. N. sativa has antioxidant activity and protective role of TQ against development of type I diabetes may be via NO inhibitory pathway. It also exerts an insulin-sensitizing action in hepatocytes. Seeds of N. sativa have been safely consumed by human patients in many clinical trials which however were not aimed to assess its antidiabetic activity. In future clinical studies may show potential of N. sativa, its constituents or their synthetic analogues, in prevention and control of diabetes.

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“…Thymoquinone, the major component of the essential oil, is the biologically active gradient of this plant (Ali and Blunden, 2003) . It was reported that, thymoquinone(TQ) has many medicinal properties like; anti-oxidant (Meral et al, 2001;Shalaby and khater, 2007;Zegarac et al, 2009 ), anti-inflammatory (Hajhashemi et al, 2004), anti-tumor (Banerjee et al, 2010), analgesic and other properties (Kaleem et al, 2006;Bhatti et al, 2009). On the other side, Kapoor ( 2009) proved that TQ protects hepatic tissue from deleterious effects of toxic metals such as lead, and attenuates hepatic lipid peroxidation following exposure to chemicals such as carbon tetrachloride.…”

Section: Introductionmentioning

confidence: 99%

Nigella sativa seeds protect against hepatotoxicity and dyslipidemia induced by carbon tetrachloride in mice

Essawy¹

2012

J. App. Pharm. Sci.

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The present study was conducted to evaluate the hepatoprotective effects of aqueous seed extract of Nigella sativa (black seed) on carbon tetrachloride (CCl4) induced liver damage in Swiss albino mice. CCl4 (1.9 ml/kg b.w.) was given orally every other day for three weeks. Aqueous suspension of N. sativa seeds (50 mg/kg b.w.) was given orally every other day alternated with CCl4 for three weeks. Blood was collected for the assessment of serum marker enzymes ( ALT, AST ,ALP and LDH) and lipid profile(triglycerides, total cholesterol, HDL and total lipids), while liver tissue was used for histopathological assessment. Serum levels of liver enzymes and lipid contents were significantly increased in animals treated with CCL4 as compared to control. Histopathological observations, also revealed severe damage in the structure of liver tissue in animals intoxicated with CCL4. Combined treatment of CCL4-exposed animals with N.sativa showed marked improvement in both biochemical and histopathological findings. Only LDH did not affect by N. sativa administration.

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Effect of Nigella sativa on Glucose Concentration, Lipid Peroxidation, Anti‐Oxidant Defence System and Liver Damage in Experimentally‐Induced Diabetic Rabbits

Cited by 167 publications

References 20 publications

Effects of Nigella sativa and silver sulfadiazine on burn wound healing in rats

Effects of Nigella sativa and silver sulfadiazine on burn wound healing in rats

Antidiabetic Properties of a Spice Plant Nigella sativa

Nigella sativa seeds protect against hepatotoxicity and dyslipidemia induced by carbon tetrachloride in mice

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