Effect of<i> Mangifera indica</i> L. extract (QF808) on protein and hepatic microsome peroxidation

Martı́nez, Gregorio; Giuliani, Attilia; León, Olga Sonia; Pérez, Giselle Debs; Sellés, Alberto J. Núñez

doi:10.1002/ptr.980

Cited by 37 publications

(34 citation statements)

References 20 publications

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“…43) The generation of reactive oxidants in biological systems, both by normal metabolic pathways or as a consequence of exposure to chemical carcinogens, has been extensively studied and has been postulated to be a major contributory factor for the multistage process of carcinogenesis.…”

Section: Discussionmentioning

confidence: 99%

Protective Role of Mangiferin against Benzo(a)pyrene Induced Lung Carcinogenesis in Experimental Animals

Rajendran

Ganapathy

Sakthisekaran

2008

Biological & Pharmaceutical Bulletin

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In recent years, considerable emphasis has been focused on identifying new chemopreventive agents which could be useful for the human population. In the present study, we examined the protective role of mangiferin during experimental lung carcinogenesis with reference to its effect on DNA-damage and the detoxification enzyme system. The activities of detoxifying enzymes such as glutathione transferase (GST), quinone reductase (QR) and uridin 5-diphosphate-glucuronosyl transferase (UDP-GT) were found to be decreased while the lipid peroxidation level was increased in the lung cancer bearing animals. Supplementation of mangiferin (100 mg/kg b.wt) enhanced the detoxification enzymes and reduced DNA damage as determined by single cell electrophoresis. Furthermore, the DNA-protein cross links which was found to be high in lung cancer bearing animals was also modulated upon supplementation with mangiferin. Our present results explain the unique association between the anti-oxidant effect of mangiferin and ultimately the capability of mangiferin to prevent cancer.

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Section: Discussionmentioning

confidence: 99%

Protective Role of Mangiferin against Benzo(a)pyrene Induced Lung Carcinogenesis in Experimental Animals

Rajendran

Ganapathy

Sakthisekaran

2008

Biological & Pharmaceutical Bulletin

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“…Among these active plant species, some of them, namely E. chlorantha [118], E. africana [119] and C. longa [120], have been reported to be active against experimentally induced hepatitis. M. indica on its part has been shown to be very effective against lipid and protein oxidation in vitro and injury associated to hepatic ischemia reperfusion [121,122]. The inhibitory effect against the free radical-mediated degradation of microsomal lipid peroxidation by plant extracts mentioned above may also be attributed to flavonoids and polyphenols as many of these phytoconstituents are known to be antioxidants [123].…”

Section: Erythrina Senegalensismentioning

confidence: 99%

African natural products with potential antioxidants and hepatoprotectives properties: a review

et al. 2016

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Free radicals are highly reactive molecules generated during oxidation reactions which in turn initiate chain reactions resulting to cellular damage. There is substantial evidence implicating free radicals especially reactive oxygen species (ROS) in the etiology of more than one hundred degenerative disorders in humans including, arthritis, atherosclerosis, ischemia and reperfusion injury of many tissues, gastritis, diabetics, central nervous system injury, acquired immunodeficiency syndrome (AIDS) and cancer. Scientific evidence postulates that bioactive compounds especially from natural products are capable of providing protection against free radicals. Consequently, few decades have witnessed a surfeit of research geared towards validating the antioxidant and hepatoprotective potential of the natural products. In this review, African natural products whose antioxidants activities were scientifically validated either in their crude extracts and/or derived products have been discussed. A total 1076 plants species representing 287 family, 132 isolated compounds and 7 insect/mollusk secreation were found. The plant species from the following families; Fababceae, Asteraceae, Lamiaceae, Moraceae, Euphorbiaceae, Combretaceae and Malvaceae have received more scientific attention than others. Analysis of the reports revealed that Combretum apiculatum, Telfaria occidentalis, Acalypha racemosa, Garcinia lucida were the most active plant extracts from African flora. The most active ROS-detoxifying phytochemicals were moracin T, U, S and R (84-87), oleanolic acid (54), 5,7,4′-trihydroxy-3,8,3′,5′-tetramethoxyflavone (89), 5,7,3′-trihydroxy-3,8,4′,5′-trimethoxyflavone (88), luteolin (3′,4′,5,7-tetrahydroxy flavone) (117) and genistein (4′,5,7-trihydroxyisoflavone) (116). The significant antioxidant potential demonstrated by some crude extracts and their constituent compounds render them good candidates for the development of new drugs. Although, the study of the mechanisms of actions as well as clinical validation of some of these isolated compounds is lacking. It is hoped that pertinent scientist and stakeholders will look further into some of these compounds for detailed authentification and subsequent commercialization.

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“…BSA was oxidised by a Fenton-type reaction (Martinez et al, 2001). The reaction was carried out in 2ml polypropylene tubes with lids.…”

Section: Bsa Oxidation Assaymentioning

confidence: 99%

Inhibition Of Microsomal Lipid Peroxidation And Protein Oxidation By Extracts From Plants Used In Bamun Folk Medicine (Cameroon) Against Hepatitis

Njayou¹,

Moundipa²,

Tchana³

et al. 2008

Afr. J. Trad. Compl. Alt. Med.

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The antioxidant activities of 53 medicinal plants used in Bamun Folk Medicine for the management of jaundice and hepatitis were investigated. The studies were done using rat hepatic microsomes for lipid peroxidation and bovine serum albumin (BSA) for carbonyl group formation. Silymarine was used as reference compound. Fifteen different extracts were effective at a dose of 200µg/ml in both experiments. Specifically, 25 extracts inhibited lipid peroxidation initiated non-enzymatically by ascorbic acid while 18 inhibited peroxidation as determined by reduced Nicotinamide Adenine Dinucleotide Phosphate (NADPH). The inhibitory concentration 50 (IC 50 ) of 23 different plant extracts was lower than 200µg/ml in the microsomal lipid peroxidation inhibition study. Fifteen of the 23 extracts were active in preventing protein oxidation by inhibiting the formation of the carbonyl group on BSA with an IC 50 value less than 200µg/ ml. The results suggest that the antioxidant activity of the extracts, may be due to their ability to scavenge free radicals involved in microsomal lipid peroxidation or in protein oxidation. These biochemical processes are involved in the aetiology of toxic hepatitis.

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Effect of Mangifera indica L. extract (QF808) on protein and hepatic microsome peroxidation

Cited by 37 publications

References 20 publications

Protective Role of Mangiferin against Benzo(a)pyrene Induced Lung Carcinogenesis in Experimental Animals

Protective Role of Mangiferin against Benzo(a)pyrene Induced Lung Carcinogenesis in Experimental Animals

African natural products with potential antioxidants and hepatoprotectives properties: a review

Inhibition Of Microsomal Lipid Peroxidation And Protein Oxidation By Extracts From Plants Used In Bamun Folk Medicine (Cameroon) Against Hepatitis

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