Effect of <i>Luffa echinata</i> on Lipid Peroxidation and Free Radical Scavenging Activity

Kumar, V. Prashanth; S, Shashidhara; Kumar, Mukesh; Sridhara, B.Y.

doi:10.1211/0022357001774589

Cited by 28 publications

(19 citation statements)

References 19 publications

(14 reference statements)

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“…49) Flavonoids have also been found to possess various other biological properties, for example, hepatoprotective, antithrombotic, and antiviral activity. 50) Many actions have been correlated with their ability to scavenge oxygen-generated free radicals and to inhibit lipid peroxidation in vitro. 50) Phytochemical results showed that the chard extracts were rich in flavonoids 18) and saponins, 17) which are known to have strong antioxidant and free radical scavenging properties.…”

Section: Discussionmentioning

confidence: 99%

“…50) Many actions have been correlated with their ability to scavenge oxygen-generated free radicals and to inhibit lipid peroxidation in vitro. 50) Phytochemical results showed that the chard extracts were rich in flavonoids 18) and saponins, 17) which are known to have strong antioxidant and free radical scavenging properties. 50) Our results indicate that chard extract is effective in controlling hyperglycemia in STZ diabetic rats.…”

Section: Discussionmentioning

confidence: 99%

“…50) Phytochemical results showed that the chard extracts were rich in flavonoids 18) and saponins, 17) which are known to have strong antioxidant and free radical scavenging properties. 50) Our results indicate that chard extract is effective in controlling hyperglycemia in STZ diabetic rats. In our other study, we observed the hypoglycemic and antidiabetic effects and the regenerating effect on B cells of the endocrine pancreas, both morphologically and biochemically.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Chard (Beta vulgarisL. var cicla) on the Liver of the Diabetic Rats: A Morphological and Biochemical Study

Saçan

Karabulut-Bulan

Bolkent

et al. 2004

Bioscience, Biotechnology, and Biochemistry

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Chard (Beta vulgarisL. var cicla) on the Liver of the Diabetic Rats: A Morphological and Biochemical Study

Saçan

Karabulut-Bulan

Bolkent

et al. 2004

Bioscience, Biotechnology, and Biochemistry

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“…Hyperglycemia-mediated oxidative stress was prevented by the intake of coffee because it contains powerful antioxidants, such as isoflavonoids, that antagonize the harmful effects of oxidative stress in diabetes (Akash et al, 2014a). Phytochemical analysis showed that the chard extracts were rich in flavonoids and saponins, which are known to have strong antioxidant and free radical scavenging properties (Kumar et al, 2000;Sacan & Yanardag, 2010). We suggested that the prominent improvement in the lung tissue of hyperglycemic rats may be related to the antioxidant activity of chard in addition to its effect of reducing hyperglycemia.…”

Section: Discussionmentioning

confidence: 99%

Chard (Beta vulgarisvar.cicla) extract improved hyperglycemia-induced oxidative stress and surfactant-associated protein alterations in rat lungs

Öztay¹,

Saçan

Kayalar³

et al. 2015

Pharmaceutical Biology

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Context: Chard is used as an antidiabetic agent by the diabetic patients in Turkey. Objective: The effect of chard extract [Beta vulgaris L. var. cicla (Chenopodiaceae)] on the antioxidant system and the expression of surfactant-associated proteins (SP) in the lungs of hyperglycemic rats were examined. Materials and methods: Hyperglycemia was induced by a single dose of streptozotocin (60 mg/kg) provided intraperitoneally. Fourteen days after the rats were rendered hyperglycemic, the chard (2 g/kg/d), insulin (6 U/kg/d), and chard plus insulin (as mentioned above) were administered to rats for 45 d. On day 60, rats' lungs were removed. Oxidative stress parameters and SP expression were assayed. Results: The lungs of hyperglycemic rats were characterized by the induced lipid and protein oxidation, elevated myeloperoxidase and xanthine oxidase activities, decreased glutathione levels, and reduced tissue factor and antioxidant enzymes activities (catalase, superoxide dismutase, glutathione peroxidase, and glutathione-S-transferase). Chard treatment alone and chard treatment combined with insulin were capable of achieving a regression of pulmonary oxidative stress, by inhibiting lipid and protein oxidation, and restoring the antioxidant system of hyperglycemic rats. SP-A expressions were significantly unchanged in all groups, whereas pro-SP-C and SP-D expressions were reduced in hyperglycemic rats. Pro-SP-C and SP-D levels were increased by chard and insulin administrations alone and combined in hyperglycemic rats. Discussion and conclusion: All treatments have a positive effect on the surfactant and antioxidant systems of the lungs of hyperglycemic rats. The best therapeutic effect was provided by treatment with chard extract alone in the compensation of hyperglycemic symptoms.

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“…Lipid peroxide inhibition activity was determined in vitro according Kumar et al, 2000. [22] Freshly collected goat liver homogenate was used as the source of polyunsaturated fatty acids for determining the extent of hepatocyte protective activity.…”

Section: Inhibition Of Lipid Peroxidation Activitymentioning

confidence: 99%

Phytochemical Screening and ln-vitro Antioxidant Profiling of Solvent Fractions of Canna edulis Ker Gawler

Mishra

Sen

2012

Free Radicals and Antioxidants

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13Fr e e R a d . A n t i ox .Re s e a r c h A r t i c l e West Bengal, apdas.nbu@gmail.com; senarnab_nbu@hotmail.com INTRODUCTIONOxygen plays a vital role in the survival of life on earth. However, during it's utilization in various life processes, a tiny amount of oxygen gets reduced to different free radicals like hydrogen peroxide, superoxide, nitric oxide, hydroxyl radicals etc. [1,2] All these reactive oxygen radicals are accountable for various health hazards to human life causing the development of degenerative diseases.[3] Antioxidant molecules, on the other hand, can slow down or cease the activity of these harmful oxygen species by being oxidizing themselves. Plants often contain good amount of natural antioxidants. [4,5] Different phytochemicals like phenols, flavonols, carotenoids, proanthocyanidins, vitamin C and E can be utilized to scavenge the excess free radicals from human body. [6] Canna edulis Ker Gawler, is a medium sized perennial flowering plant found in the north eastern Himalayan regions of India.[7] The plants bear broad, flat, blackish green leaves with spectacular red flowers. Besides, it also tickles our test buds as it is known to be edible and mainly consumed by the Indian tribes like Lepchas, Bhutias and Nepalis. [8] Different parts of the plants like rhizomes, leaves and seeds are used as medicines by the tribal communities of North eastern India.[9] Amongst various plant parts the extracts of rhizomes are rich source of polyphenolic compounds like phenols and flavonoids, [10] which in turn provide the evidences of antioxidative properties of the plant. ABSTRACT Introduction:Canna edulis Ker Gawler, grown in the sub Himalayan region containing starchy rhizome are used by the tribal people as food and herbal medicine. Methods: Investigations were done to find out 2,2-diphenyl-1-picryl hydrazyl (DPPH) radical scavenging activity, total flavonols and total proanthocyanidin contents, nitric oxide (NO) scavenging activity, hydroxyl radical scavenging activity of different solvent fractions of aquous extract of C. edulis rhizome. Among the cellular molecules, lipids containing unsaturated fatty acids with more than one double bond are particularly susceptible to action of free radicals. The resulting reaction, known as lipid peroxidation and anti lipid peroxidation activity has been performed using goat liver homogenate. Results: Six out of 29 fractions showed DPPH free radical inhibition above 75% and were used for further phytochemical screening. Diethyl ether : ethyl acetate (1:3) fraction showed the maximum inhibition percent. Highest amount of total flavonol and total proanthocyanidins were recorded in diethyl ether : ethyl acetate (1:3) fraction. Maximum NO scavenging activity and hydroxyl radical inhibition activity were observed in bioactive diethyl ether : ethyl acetate (1:1) fraction. Inhibition of lipid peroxides was maximum in ethyl acetate fraction. Data from thin layer chromatography (TLC) revealed the presence of phenolic compounds in all fractions, whereas flavono...

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Effect of Luffa echinata on Lipid Peroxidation and Free Radical Scavenging Activity

Cited by 28 publications

References 19 publications

Effects of Chard (Beta vulgarisL. var cicla) on the Liver of the Diabetic Rats: A Morphological and Biochemical Study

Effects of Chard (Beta vulgarisL. var cicla) on the Liver of the Diabetic Rats: A Morphological and Biochemical Study

Chard (Beta vulgarisvar.cicla) extract improved hyperglycemia-induced oxidative stress and surfactant-associated protein alterations in rat lungs

Phytochemical Screening and ln-vitro Antioxidant Profiling of Solvent Fractions of Canna edulis Ker Gawler

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