Effect of <i>Lactobacillus rhamnosus</i> GG and vitamin D supplementation on the immunologic effectiveness of grass-specific sublingual immunotherapy in children with allergy

Jerzyńska, Joanna; Stelmach, Włodzimierz; Balcerak, Joanna; Woicka-Kolejwa, Katarzyna; Rychlik, Błażej; Błauż, Andrzej; Wachulec, Marcin; Stelmach, Piotr; Majak, Paweł; Stelmach, Iwona

doi:10.2500/aap.2016.37.3958

Cited by 51 publications

(41 citation statements)

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“…The beneficial effect of probiotics in allergy processes is well described [81][82][83]. The IgE increase is one of the most relevant signs that characterize this process.…”

Section: Mechanisms Induced By Probiotics To Stimulate the Immune Systemmentioning

confidence: 99%

Beneficial Effects of Probiotic Consumption on the Immune System

Galdeano¹,

Cazorla²,

Dumit³

et al. 2019

Ann Nutr Metab

462

219

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Background: The gastrointestinal tract is one of the most microbiologically active ecosystems that plays a crucial role in the working of the mucosal immune system (MIS). In this ecosystem, the consumed probiotics stimulate the immune system and induce a network of signals mediated by the whole bacteria or their cell wall structure. This review is aimed at describing the immunological mechanisms of probiotics and their beneficial effects on the host. Summary: Once administered, oral probiotic bacteria interact with the intestinal epithelial cells (IECs) or immune cells associated with the lamina propria, through Toll-like receptors, and induce the production of different cytokines or chemokines. Macrophage chemoattractant protein 1, produced by the IECs, sends signals to other immune cells leading to the activation of the MIS, characterized by an increase in immunoglobulin A⁺ cells of the intestine, bronchus and mammary glands, and the activation of T cells. Specifically, probiotics activate regulatory T cells that release IL-10. Interestingly, probiotics reinforce the intestinal barrier by an increase of the mucins, the tight junction proteins and the Goblet and Paneth cells. Another proposed mechanism of probiotics is the modulation of intestinal microbiota by maintaining the balance and suppressing the growth of potential pathogenic bacteria in the gut. Furthermore, it has been demonstrated that long-term probiotics consumption does not affect the intestinal homeostasis. The viability of probiotics is crucial in the interaction with IECs and macrophages favoring, mainly, the innate immune response. Macrophages and Dendritic cells (DCs) play an important role in this immune response without inducing an inflammatory pattern, just a slight increase in the cellularity of the lamina propria. Besides, as part of the machinery that probiotics activate to protect against different pathogens, an increase in the microbicidal activity of peritoneal and spleen macrophages has been reported. In malnutrition models, such as undernourishment and obesity, probiotic was able to increase the intestinal and systemic immune response. Furthermore, probiotics contribute to recover the histology of both the intestine and the thymus damaged in these conditions. Probiotic bacteria are emerging as a safe and natural strategy for allergy prevention and treatment. Different mechanisms such as the generation of cytokines from activated pro-T-helper type 1, which favor the production of IgG instead of IgE, have been proposed. Key Messages: Probiotic bacteria, their cell walls or probiotic fermented milk have significant effects on the functionality of the mucosal and systemic immune systems through the activation of multiple immune mechanisms.

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“…The beneficial effect of probiotics in allergy processes is well described [81][82][83]. The IgE increase is one of the most relevant signs that characterize this process.…”

Section: Mechanisms Induced By Probiotics To Stimulate the Immune Systemmentioning

confidence: 99%

Beneficial Effects of Probiotic Consumption on the Immune System

Galdeano¹,

Cazorla²,

Dumit³

et al. 2019

Ann Nutr Metab

462

219

View full text Add to dashboard Cite

show abstract

“…However, only a limited number of studies have so far evaluated the influence of beneficial bacterial strains in the context of successful allergen‐specific immunotherapy (AIT). Beneficial immunomodulatory and clinical effects of probiotic supplementation were observed when using different probiotic strains such as L rhamnosus in a randomized clinical trial of peanut oral immunotherapy or in grass‐pollen sublingual immunotherapy (SLIT) or by combining SCIT with Clostridium butyricum supplementation . Thus, major research efforts will be essential in the future to close this current knowledge gap and to ensure optimized AIT formulations for efficient treatment of allergic patients.…”

Section: Translational Implications Of Microbiotamentioning

confidence: 99%

AllergoOncology: Microbiota in allergy and cancer—A European Academy for Allergy and Clinical Immunology position paper

Untersmayr

Bax

Bergmann³

et al. 2019

Allergy

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The microbiota can play important roles in the development of human immunity and the establishment of immune homeostasis. Lifestyle factors including diet, hygiene, and exposure to viruses or bacteria, and medical interventions with antibiotics or anti‐ulcer medications, regulate phylogenetic variability and the quality of cross talk between innate and adaptive immune cells via mucosal and skin epithelia. More recently, microbiota and their composition have been linked to protective effects for health. Imbalance, however, has been linked to immune‐related diseases such as allergy and cancer, characterized by impaired, or exaggerated immune tolerance, respectively. In this AllergoOncology position paper, we focus on the increasing evidence defining the microbiota composition as a key determinant of immunity and immune tolerance, linked to the risk for the development of allergic and malignant diseases. We discuss novel insights into the role of microbiota in disease and patient responses to treatments in cancer and in allergy. These may highlight opportunities to improve patient outcomes with medical interventions supported through a restored microbiome.

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“…(1) Since natural supplements are complex mixtures, their net efficacy results from multiple interactions among the constituents. (2)(3)(4) Effects of natural dietary supplements have been published in various fields, such as their ability to improve in mitochondrial dysfunction. (5) Interest in natural supplements is growing, and many relevant studies are ongoing around the world.…”

mentioning

confidence: 99%

“…Several papers have reported that those natural supplements show synergism. (2)(3)(4) Jerzynska et al (3) reported that co-administration of vitamin D supplements and Lactobacillus rhamnosus showed better immunological response than individual administration in pediatric allergy rhinitis patients. These natural supplements show similar properties, but combining them can generate additive or synergistic effects on the human body.…”

mentioning

confidence: 99%

A natural supplement formula reduces anti-oxidative stress and enhances osteo-chondrogenic differentiation potential in mesenchymal stem cells

Kim

Heck³

et al. 2020

J. Clin. Biochem. Nutr.

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There is great interest in using natural supplements to treat various medical conditions. In this study, we evaluated the anti oxidative and stem cell differentiation effects of a mixture of vitamin D, Lactobacillus rhamnosus, ginger, curcumin, and Boswellia extract. The calcein acetoxymethyl assay after H 2 O 2 treatment showed that combined natural supplement had an anti oxidative effect. NS J also increased calcium deposition, as shown by Alizarin Red S staining, indicating bone formation activity. The contents of type II collagen and glycosaminoglycans, which are biomarkers of cartilage, were higher in mesenchymal stem cells treated with combined natural supplement than in cells treated with individual ingredients of the formula. In mesenchymal stem cells treated with human osteoarthritis synovial fluids, combined natural supplement enhanced the expression of type II collagen and PPAR δ, over coming the anti chondrogenic effect of inflammatory conditions. Combined natural supplement also inhibited Oil red O staining in cells, which indicates inhibited adipogenesis. Thus, combined natural supplement, a formula comprising vitamin D, Lactobacillus rhamnosus, ginger, curcumin and Boswellia extract, reduced oxi dative stress, enhanced osteogenesis and chondrogenesis, and inhibited adipogenesis in mesenchymal stem cells to a greater extent than the individual ingredients, indicating synergistic inter action. In addition, combined natural supplement increased the expression PPAR δ, suggesting that these effects correlate with the PPAR δ pathway.

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Effect of Lactobacillus rhamnosus GG and vitamin D supplementation on the immunologic effectiveness of grass-specific sublingual immunotherapy in children with allergy

Abstract: We demonstrated the clinical and immunologic effect of probiotic and vitamin D supplementation on SLIT. Probiotic supplementation showed better clinical and immunologic response in children with allergic rhinitis.

Cited by 51 publications

References 0 publications

Beneficial Effects of Probiotic Consumption on the Immune System

Beneficial Effects of Probiotic Consumption on the Immune System

AllergoOncology: Microbiota in allergy and cancer—A European Academy for Allergy and Clinical Immunology position paper

A natural supplement formula reduces anti-oxidative stress and enhances osteo-chondrogenic differentiation potential in mesenchymal stem cells

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