Effect of<i>IL-6</i>C-572G polymorphism on idiopathic membranous nephropathy risk in a han chinese population

Chen, Shih Yin; Chen, Cheng Hsu; Huang, Yu Chuen; Chuang, Hsuan Min; Lo, Ming Min; Tsai, Fuu Jen

doi:10.3109/0886022x.2010.516857

Cited by 23 publications

(12 citation statements)

References 22 publications

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“…High levels of LPS activate the NF-κB pathway and lead to the production of pro-inflammatory cytokines(TNF-α, IL-6, and IL-1) 41 . In agreement with this observation, higher abundance of Escherichia-Shigella and Bacteroides increases the circulating levels of pro-inflammatory cytokines such as TNF-α and IL-6, and genetic polymorphisms in these cytokines are associated with the onset/occurrence of MN 42,43 . Actinomyces has been identified to be abundant in patients with rheumatoid arthritis 44 and ulcerative colitis 45 .…”

Section: Investigation Of the Relationships Between Clinical Parametesupporting

confidence: 69%

A Comparative Study of the Gut Microbiota Associated with Immunoglobulin A Nephropathy and Membranous Nephropathy

Sun

Dong

Bai

et al. 2020

Preprint

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Background The pathogenesis of immunoglobulin A nephropathy (IgAN) and membranous nephropathy (MN) is characterized by immune dysregulation, which is related to gut dysbiosis. The aim of the study was to compare the gut microbiota of patients with IgAN and MN versus healthy controls. We used 16S rDNA amplicon sequencing to investigate the bacterial communities of 44 patients with kidney biopsy-proven IgAN, 40 patients with kidney biopsy-proven MN, and 30 matched healthy controls (HC). Results The abundance of Escherichia-Shigella and Defluviitaleaceae_incertae_sedis were significantly higher in IgAN than in HC, whereas lower abundances were observed for Roseburia, Lachnospiraceae_ unclassified, Clostridium_sensu_stricto_1, and Fusobacterium . Furthermore, the abundance of Escherichia-Shigella, Peptostreptococcaceae_incertae_sedis , Streptococcus, and Enterobacteriaceae_ unclassified increased, while that of Lachnospira, Lachnospiraceae_ unclassified, Clostridium_sensu_stricto_1, and Veillonella decreased in MN. The abundance of Megasphaera and Bilophila was higher, whereas that of Megamonas, Veillonella, Klebsiella, and Streptococcus was lower in patients with IgAN than in those with MN. Analysis of the correlations showed that in the IgAN group, Prevotella was positively correlated, while Klebsiella , Citrobacter, and Fusobacterium were negatively correlated with the level of serum albumin. Positive correlation also existed between Bilophila and Crescents in the Oxford classification of IgAN. In the MN group, negative correlation was observed between Escherichia-Shigella and proteinuria, Bacteroides and Klebsiella showed positive correlation with the MN stage. Conclusions Patients with IgAN and MN exhibited gut microbial signatures distinct from healthy controls. Our study suggests the potential of gut microbiota as specific biomarker and contributor in the pathogenesis of IgAN and MN.

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Section: Investigation Of the Relationships Between Clinical Parametesupporting

confidence: 69%

A Comparative Study of the Gut Microbiota Associated with Immunoglobulin A Nephropathy and Membranous Nephropathy

Sun

Dong

Bai

et al. 2020

Preprint

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“…31 Supporting this notion, air pollution increases the circulating levels of inflammation mediators such as TNF-a, IL-6, and plasminogen activator inhibitor-1, 21,32,33 and genetic polymorphisms in these cytokines are associated with the development of MN. [34][35][36][37][38] It would also be interesting to test the existence of any interactions between PM 2.5 exposure and the genetic polymorphisms implicated in MN. 39 There were limitations in our study.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Exposure to Air Pollution and Increased Risk of Membranous Nephropathy in China

Wang

Chen

et al. 2016

JASN

370

282

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The effect of air pollution on the changing pattern of glomerulopathy has not been studied. We estimated the profile of and temporal change in glomerular diseases in an 11-year renal biopsy series including 71,151 native biopsies at 938 hospitals spanning 282 cities in China from 2004 to 2014, and examined the association of long-term exposure to fine particulate matter of <2.5 μm (PM) with glomerulopathy. After age and region standardization, we identified IgA nephropathy as the leading type of glomerulopathy, with a frequency of 28.1%, followed by membranous nephropathy (MN), with a frequency of 23.4%. Notably, the adjusted odds for MN increased 13% annually over the 11-year study period, whereas the proportions of other major glomerulopathies remained stable. During the study period, 3-year average PM exposure varied among the 282 cities, ranging from 6 to 114 μg/m (mean, 52.6 μg/m). Each 10 μg/m increase in PM concentration associated with 14% higher odds for MN (odds ratio, 1.14; 95% confidence interval, 1.10 to 1.18) in regions with PM concentration >70 μg/m We also found that higher 3-year average air quality index was associated with increased risk of MN. In conclusion, in this large renal biopsy series, the frequency of MN increased over the study period, and long-term exposure to high levels of PM was associated with an increased risk of MN.

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“…It has been hypothesized that cytokines generated in the airways in response to air pollution can spill over into the circulation, influencing autoimmune responses and distant events [89]. Air pollution increases the circulating levels of inflammation mediators, such as TNF-α, IL-6, and plasminogen activator inhibitor-1 [88, 90], and genetic polymorphisms in these cytokines are associated with the development of MN [91-95]. …”

Section: Environmental Studies Of Pmnmentioning

confidence: 99%

The Genetic and Environmental Factors of Primary Membranous Nephropathy: An Overview from China

2018

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Background: Primary membranous nephropathy (pMN) is the most common cause of nephrotic syndrome in adults. The discovery of the 2 autoantigens, M-type phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A), has defined pMN as an autoimmune disease. A remarkable increase in the frequency of pMN in primary glomerular disease was witnessed in China. The genetic and environmental contributors to disease susceptibility have been investigated in these patients. Summary: We reviewed recent publications in genetic and environmental studies of pMN, focusing mainly on those undertaken in China. Following a genome-wide association study, the gene-gene interaction between the 2 most significant risk factors, PLA2R1 and DQA1, was validated in Chinese patients with MN. Fine mapping on human leukocyte antigen (HLA) locus found that DRB1*1501 and DRB1*0301 were risk alleles. Three amino acid residues on positions 13 and 71 of HLA-DRβ1 chain may confer the susceptibility to pMN by presenting T-cell epitopes on PLA2R. Another study found that DRB3*0202 was the most likely culprit allele for the signal at DRB1*0301. One environmental risk factor for pMN has been identified as the long-term exposure to high levels of PM_2.5 in Chinese patients with MN. Each 10 μg/m³ increase in PM_2.5 concentration was associated with 14% higher odds for pMN in the regions with PM_2.5 above 70 μg/m³. Key Message: A gene-environment interaction is suspected as an underlying mechanism for the increasing trend of pMN in China.

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Effect ofIL-6C-572G polymorphism on idiopathic membranous nephropathy risk in a han chinese population

Cited by 23 publications

References 22 publications

A Comparative Study of the Gut Microbiota Associated with Immunoglobulin A Nephropathy and Membranous Nephropathy

A Comparative Study of the Gut Microbiota Associated with Immunoglobulin A Nephropathy and Membranous Nephropathy

Long-Term Exposure to Air Pollution and Increased Risk of Membranous Nephropathy in China

The Genetic and Environmental Factors of Primary Membranous Nephropathy: An Overview from China

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