Effect ofHelicobacter pyloriInfection on Gastric Juice pH

Furuta, Shinpei

doi:10.1080/00365529850170973

Cited by 73 publications

(13 citation statements)

References 21 publications

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“…This significant improvement of acidity after eradication seems to be consistent with previous work by Furuta et al [30]. They showed that fasting gastric juice pH of H. pylori positive gastric ulcer changes significantly from 6 to 2 after eradication.…”

Section: Discussionsupporting

confidence: 81%

Cutoff Pepsinogen Level for Predicting Unintendedly Eradicated Cases of Helicobacter pylori Infection in Subjects with Seemingly Normal Pepsinogen Levels

Kishikawa¹,

Kimura²,

Ito³

et al. 2017

Digestion

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Backgrounds/Aims: In the ABC method, which is a method for risk stratification of gastric cancer using serum anti-Helicobacter pylori antibody and pepsinogen (PG) test, subjects with normal PG and seronegative for H. pylori are named as “Group A” and are regarded as having a low risk of gastric cancer. These “Group A” subjects include unintentionally eradicated cases at relatively high risk, and this study aimed to identify these subjects. Methods: Of the 109 subjects, 76 were classified as uninfected Group A subjects with negative histologic H. pylori infection and no histologic and endoscopic atrophy, and 33 subjects were classified serologically as Group A after successful eradication, which are serologically equal to the unintendedly eradicated cases in Group A. The usefulness of measuring PG levels to detect post-eradication cases was validated by using a receiver operating characteristic (ROC) curve analysis. Results: The area under the ROC curve for PGI level was 0.736 ± 0.06 (p < 0.01; cutoff value, 37.0 ng/mL; sensitivity, 77.6%; specificity, 72.7%), and that for the PGI/II ratio was 0.660 ± 0.06 (p < 0.01; cutoff value, 5.1; sensitivity, 84.2%; specificity, 43.4%). Conclusion: PGI levels of ≤37 ng/mL and PGI/II ratios of ≤5.1 effectively identified unintendedly eradicated cases in Group A.

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Section: Discussionsupporting

confidence: 81%

Cutoff Pepsinogen Level for Predicting Unintendedly Eradicated Cases of Helicobacter pylori Infection in Subjects with Seemingly Normal Pepsinogen Levels

Kishikawa¹,

Kimura²,

Ito³

et al. 2017

Digestion

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“…However, this technique is relatively invasive and is difficult to be routinely performed for all patients with acid-related disorders. For this reason, we measured the pH of gastric juice samples collected by aspiration during endoscopy, as this approach has also been used to evaluate acid secretion [23,24,25]. Using one-point measurements, we found that gastric juice pH was significantly associated with gastric mucosal injury induced by LDA.…”

Section: Discussionmentioning

confidence: 99%

Association of Gastric Mucosal Injury Severity with Platelet Function and Gastric pH during Low-Dose Aspirin Treatment

et al. 2013

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Introduction: The antiplatelet effects of low-dose aspirin (LDA) vary between individuals. Here, we investigated the relationship between the incidence of LDA-induced mucosal injury, antiplatelet effects of LDA, and intragastric pH. Methods: We evaluated gastric injury severity and platelet function using the VerifyNow® System before and after administration of 100 mg aspirin for 7 days to 18 young healthy subjects (study 1). We investigated whether injury was correlated with platelet function and gastric juice pH in 45 patients with cardiovascular disease administered LDA daily (study 2). Results: In study 1, platelet aggregation was attenuated by LDA to different degrees. Although 55.6% of subjects (10/18) developed gastric injury of modified Lanza score (MLS) ≥3, no significant difference in platelet function was detected between the mild (n = 8, MLS: 0-2) and severe injury groups (n = 10, MLS: 3-5). In study 2, the severity of LDA-induced injury was associated with gastric juice pH, but not with antiplatelet effects of LDA. Discussion: In contrast to gastric juice pH, the antiplatelet effect had no correlation with the severity of gastric mucosal injury. Monitoring gastric acidity, rather than platelet function, may be useful for predicting the risk of gastric injury during LDA treatment.

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“…Moreover, it should be noted that 20 out of 21 studies demonstrated the reduced level of serum gastrin by H. pylori eradication therapy, suggesting improvement of inflammation in the corpus (table 2) [18, 19, 21, 22,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49]. The level of somatostatin and the number of D cells have been reported to increase after therapy [38, 45,][50], although this requires biopsy specimens for the estimation.…”

Section: Pepsinogen Gastrin and Gastric Acid Secretionmentioning

confidence: 99%

Biomarkers in Patients with Gastric Inflammation: A Systematic Review

et al. 2005

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Background: The importance of examining the status of gastric inflammation has been acknowledged; the new classification by the updated Sydney system (USS) allows us to evaluate the quantitative status of gastric inflammation. However, this system is based on the histological classification derived from biopsy specimens. Therefore, more convenient, objective and practical biomarkers are recommended. Aim: We undertook a systematic review to find out potential biomarkers by summarizing the relationship between biomarkers and grades of inflammation. Methods: By a primary search via Medline up to December 2004, we extracted a total of 6,526 papers that described biomarkers for human gastric inflammation. All papers were screened by title and abstract. The authors then retrieved 435 citations for complete review; ultimately 231 were appropriate for inclusion criteria. These papers were subclassified into several categories and summarized by each author. Results: In addition to standard markers such as pepsinogens, we confirmed the close relationship between the levels of several biomarkers including gastrin, interleukin-8, HLA class II molecules, reactive oxygen species, and the histological grades. Conclusions: This review provides valuable information describing the clinical implication of these biomarkers for evaluating the static conditions or dynamic alterations of human gastric inflammation.

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Effect ofHelicobacter pyloriInfection on Gastric Juice pH

Abstract: These findings suggest that H. pylori infection and gastritis in the corpus suppress acid secretion and increase gastric juice pH, resulting in hypergastrinemia, and that eradication of H. pylori normalizes acid secretion and serum gastrin levels.

Cited by 73 publications

References 21 publications

Cutoff Pepsinogen Level for Predicting Unintendedly Eradicated Cases of <b><i>Helicobacter pylori</i></b> Infection in Subjects with Seemingly Normal Pepsinogen Levels

Cutoff Pepsinogen Level for Predicting Unintendedly Eradicated Cases of <b><i>Helicobacter pylori</i></b> Infection in Subjects with Seemingly Normal Pepsinogen Levels

Association of Gastric Mucosal Injury Severity with Platelet Function and Gastric pH during Low-Dose Aspirin Treatment

Biomarkers in Patients with Gastric Inflammation: A Systematic Review

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