Effect of <i>Coprinus atramentarius</i> on the metabolism of ethanol in mice

Coldwell, Blake B.; Genest, K.; Hughes, Debbie

doi:10.1111/j.2042-7158.1969.tb08223.x

Cited by 16 publications

(7 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the exact mechanism of coprine toxicity is still unknown, the data suggest coprine or a coprine metabolite inhibits aldehyde dehydrogenase (ALDH), resulting in elevation of acetaldehyde levels. In vitro studies have not been able to demonstrate coprine inhibition of ALDH, the enzyme responsible for the conversion of acetaldehyde to acetic acid; however, the hydrolytic product of coprine, 1-aminocyclopropanol hydrochloride, does inhibit ALDH (58)(59)(60)(61)(62).…”

Section: Disulfiram-likementioning

confidence: 97%

Mycotoxins revisited: Part II

Berger

Guss

2005

The Journal of Emergency Medicine

View full text Add to dashboard Cite

Mushrooms are ubiquitous in nature. They are an important source of nutrition, however, certain varieties contain chemicals that can be highly toxic to humans. Industrially cultivated mushrooms are historically very safe, whereas foraging for mushrooms or accidental ingestion of mushrooms in the environment can result in serious illness and death. The emergency department is the most common site of presentation for patients suffering from acute mushroom poisoning. Although recognition can be facilitated by identification of a characteristic toxidrome, the presenting manifestations can be variable and have considerable overlap with more common and generally benign clinical syndromes. The goal of this two-part article is to review the knowledge base on this subject and provide information that will assist the clinician in the early consideration, diagnosis and treatment of mushroom poisoning. Part I reviewed the epidemiology and demographics of mushroom poisoning, the physical characteristics of the most toxic varieties, the classification of the toxic species, and presented an overview of the cyclopeptide-containing mushroom class. Part II is focused on the presentation of the other classes of toxic mushrooms along with an up-to-date review of the most recently identified poisonous varieties.

show abstract

Section: Disulfiram-likementioning

confidence: 97%

Mycotoxins revisited: Part II

Berger

Guss

2005

The Journal of Emergency Medicine

View full text Add to dashboard Cite

show abstract

“…They interact with alcohol and prevent acetaldehyde from alcohol metabolism being converted to acetate [22]. The accumulated acetaldehyde reacts with the b -adrenergic receptors of the autonomic nervous system to produce violent and unpleasant vasomotor responses.…”

Section: True Fungi (Basidiospores and Ascospores)mentioning

confidence: 99%

Moulds, Yeasts, Ascospores, Basidiospores, Algae and Lichens: Toxic and Allergic Reactions

Eaton¹

2002

Journal of Nutritional & Environmental Medicine

View full text Add to dashboard Cite

The classi cation, descriptions and distribution of moulds, yeasts, ascospores, basidiospores, algae and lichens are reviewed. As adverse effects on health may be due to either toxicity, allergy or both, the effects of these are presented. The nature of allergic reactions is evaluated, presenting the possibility that most responses are due to type B allergy, rather than type A. There is a need for more research studies.

show abstract

“…marked increase in sleeping-time compared to that after ethanol alone (Genest et al 1968). This interaction was accompanied by an increased bloodlevel of acetaldehyde as compared to animals receiving ethanol only (Coldwell et al 1969).…”

mentioning

confidence: 90%

On the Disulfiram‐Like Effect of Coprine, the Pharmacologically Active Principle of Coprinus atramentarius

Carlsson¹,

Henning²,

Lindberg³

et al. 1978

Acta Pharmacologica et Toxicologica

View full text Add to dashboard Cite

Coprine or disulfiram was given to rats in various doses at various time intervals before the administration of 2 g/kg ethanol. The ratio acetaldehyde/ethanol in the alveolar air was measured by gas chromatography and was taken as an index of the aldehyde dehydrogenase (ALDH) activity. The activity of dopamine β‐hydroxylase (DBH) was estimated in the same animals by measuring the amount of 14C‐octopamine formed from 14C‐tyramine in the heart. Coprine and disulfiram both caused an increase in the acetylaldehyde/ethanol ratio, coprine being more potent than disulfiram. Disulfiram, but not coprine, reduced the net yield of 14C‐octopamine. In rats pretreated with either coprine or disulfiram, blood‐pressure and heart‐rate were recorded before and after intraperitoneal injections of 0.4 g/kg ethanol. In both cases ethanol caused a marked and rapid fall in blood‐pressure. However, this effect was accompanied by tachycardia only in animals treated with coprine. It is concluded that coprine like disulfiram inhibits ALDH, but only disulfiram causes an additional inhibition of DBH. This difference may account for differences in the cardiovascular response to ethanol

show abstract

Effect of Coprinus atramentarius on the metabolism of ethanol in mice

Cited by 16 publications

References 4 publications

Mycotoxins revisited: Part II

Mycotoxins revisited: Part II

Moulds, Yeasts, Ascospores, Basidiospores, Algae and Lichens: Toxic and Allergic Reactions

On the Disulfiram‐Like Effect of Coprine, the Pharmacologically Active Principle of Coprinus atramentarius

Contact Info

Product

Resources

About