Effect of <i>Clostridium butyricum</i> on the formation of primary choledocholithiasis based on intestinal microbiome and metabolome analysis

Li, Guofu; Yu, Tingting; Du, Hong; Zhang, Lichao; Liu, Xiaoxuan; Hou, Senlin

doi:10.1093/jambio/lxad170

Cited by 2 publications

(2 citation statements)

References 34 publications

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“…In our research, the Genus Clostridiumsensustricto1 displayed a positive association with the risk of GSD. Several earlier investigations have documented an association between Clostridium and GSD ( Grigor'eva and Romanova, 2020 ; Li et al, 2023 ). These findings indicate that Clostridiumsensustricto1 could potentially be considered a contributing factor to GSD.…”

Section: Discussionmentioning

confidence: 98%

Gut microbiota, circulating metabolites, and gallstone disease: a Mendelian randomization study

Hu,

Binxu,

Shao

et al. 2024

Front. Microbiol.

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BackgroundThe link between Gut microbiota (GM) and Gallstone disease (GSD) is well established, but it is not clear whether there is a causal relationship between the two associations.MethodsWe conducted bidirectional Mendelian randomization (MR) analyses, leveraging aggregated data from the Genome-Wide Association Study (GWAS) of GM and Circulating Metabolites. Our primary objective was to investigate the causal interplay between intestinal flora and GSD. Additionally, we performed mediational analyses, two-step MR, and multivariate MR to uncover the potential mediating effect of circulating metabolites in this relationship.ResultOur study has revealed a causal relationship between GSD and six distinct bacterial groups. Genetically predicted Class Bacilli (Odds Ratio (OR): 0.901, 95% Confidence Interval (95% CI): 0.825–0.985; p = 0.021), Order Lactobacillales (OR: 0.895, 95% CI: 0.816–0.981; p = 0.017), and Genus Coprococcus 2 (OR: 0.884, 95% CI: 0.804–0.973; p = 0.011) were inversely associated with the risk of GSD. Conversely, the Genus Clostridiumsensustricto1 (OR: 1.158, 95% CI: 1.029–1.303; p = 0.015), Genus Coprococcus3 (OR: 1.166, 95% CI: 1.024–1.327; p = 0.020), and Genus Peptococcus (OR: 1.070, 95% CI: 1.017–1.125; p = 0.009) were positively associated with the risk of GSD. Moreover, our findings suggest that the positive influence of the Genus Peptococcus on GSD may be mediated through Omega-3 polyunsaturated fatty acids (PUFA).ConclusionThis study reinforces the connection between the gut microbiome and the risk of GSD while also unveiling the mediating role of Omega-3 PUFA in the causal relationship between these factors.

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Section: Discussionmentioning

confidence: 98%

Gut microbiota, circulating metabolites, and gallstone disease: a Mendelian randomization study

Hu,

Binxu,

Shao

et al. 2024

Front. Microbiol.

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“…Compared to the normal control group, the abundance of the phylum Firmicutes, the proportion of Firmicutes/Bacteroidetes, and the genus Desulfovibrio were significantly increased in a lithogenic mouse model. The relative abundance of Bacteroidetes and Prevotella was decreased (Li et al, 2023). Hu et al found that Desulfovibrionales was enriched in patients with GS.…”

Section: Gallstones and Intestinal Bacteriamentioning

confidence: 99%

Intestinal microbiota and biliary system diseases

Wang,

Gong,

Chen

et al. 2024

Front. Cell. Infect. Microbiol.

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IntroductionThe incidence of biliary system diseases has been continuously increasing in the past decade. Biliary system diseases bring a heavy burden to humanity and society. However, the specific etiology and pathogenesis are still unknown. The biliary system, as a bridge between the liver and intestine, plays an indispensable role in maintaining the physiological metabolism of the body. Therefore, prevention and treatment of biliary diseases are crucial. It is worth noting that the microorganisms participate in the lipid metabolism of the bile duct, especially the largest proportion of intestinal bacteria.MethodsWe systematically reviewed the intestinal microbiota in patients with gallstones (GS), non-calculous biliary inflammatory, and biliary tract cancer (BTC). And searched Pubmed, Embase and Web of science for research studies published up to November 2023.ResultsWe found that the abundance of Faecalibacterium genus is decreased in GS, primary sclerosing cholangitis (PSC), primary biliary cholangitis (PBC) and BTC. Veillonella, Lactobacillus, Streptococcus and Enterococcus genus were significantly increased in PSC, PBC and BTC. Interestingly, we found that the relative abundance of Clostridium was generally reduced in GS, PBC and BTC. However, Clostridium was generally increased in PSC.DiscussionThe existing research mostly focuses on exploring the mechanisms of bacteria targeting a single disease. Lacking comparison of multiple diseases and changes in bacteria during the disease process. We hope to provide biomarkers forearly diagnosis of biliary system diseases and provide new directions for the mechanism of intestinal microbiota in biliary diseases.

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Effect of Clostridium butyricum on the formation of primary choledocholithiasis based on intestinal microbiome and metabolome analysis

Cited by 2 publications

References 34 publications

Gut microbiota, circulating metabolites, and gallstone disease: a Mendelian randomization study

Gut microbiota, circulating metabolites, and gallstone disease: a Mendelian randomization study

Intestinal microbiota and biliary system diseases

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