Effect of <i>Chlorella vulgaris</i> on Liver Function Biomarkers: a Systematic Review and Meta-Analysis

Yarmohammadi, Samira; Hosseini-Ghatar, Reza; Foshati, Sahar; Moradi, Masoud; Hemati, Niloofar; Moradi, Sajjad; Kermani, Mohammad Ali Hojjati; Farzaei, Mohammad Hosein; Khan, Haroon

doi:10.7762/cnr.2021.10.1.83

Cited by 6 publications

(5 citation statements)

References 34 publications

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“…Additionally, they discovered that C. pyrenoidosa reduced lipid peroxide levels and restored normal triglyceride levels in rat serum. When compared to earlier research, the current study revealed limited impacts on cell viability; this could be because the current study utilized a low concentration 33,34 .…”

Section: Figure 3 General Biofilm Structure Before and After The Trea...contrasting

confidence: 61%

تقييم التضاد الحيوي والنشاط السمي للخلايا من قبل الطحالب الدقيقة التي تم عزلها من مواقع مختلفة في بيتواتا- اربيل/العراق

Anwer,

Ali,

Kart

et al. 2024

Baghdad Sci.J

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تمتلك الطحالب الدقيقة, نظرأ لسهولة زراعتها ونموها السريع وتجددها, امكانات كمصدر للمركبات النشطة بيولوجيأ للاغراض الصناعية والطبية. تهدف هذه الدراسة التي اجريت بشكل (in vivo) الى تقيم القدرة المضادة للاغشية الحيوية والسموم الحيوية لطحالب الدقيقة مختارة وعزلات البكتريا الزرقاء. تم اختيار تراكيز مختلفة من عزلات الطحالب الدقيقة في كل من دراسات المضادات الحيوية والخلاية السامة . تمت اضافة مستخلص اجمالي قدره 10 ميكروليترمنMTT الى كل بئر باستخدام مرقLB , وتمت قراءة اللوحات باستخدام مقياس الطيف الضوئي للوحة ميكروتيتر عند 490 نانوميترو 630 نانوميتر, على التوالي. تم تحديد بقاء قدرة الخلية في خلايا CCD-18Co (3x103 cells/well) بواسطة اختبار MTTعند 590 نانوميتر. اظهرت عزلات الطاحالب الدقيقة تاثير مضاد حيوي بعد 48 ساعة على Pseudomonas aeruginosa PA01 ولوحظ ان هذا التاثير اعلى من تاثيره على S. aureus. Chlorella sp. اظهر الحد الاقصى لنشاط المضاد الحيوي بينما لم يكن لدى Arthrospira platensis اي نشاط تثبيط للاغشية الحيوية. Chlorella sp. تثبط حوالي %82.67 من الغشاء الحيوي في تركيز 5 ملغم \مل . علاوة على ذلك فان التاثيرات المضادة للاغشية الحيوية ل (Chara sp. و Spyrogyra sp.1) وصلت بنسبة الى %79.01 و %76.31 عند 1 ملغم\مل على التوالي. من بين جميع العزلات الطحالب الدقيقة, لوحظ وجود تاثير مثبط معتدل على الاغشية الحيوية ل Pseudomonas aeruginosa مع Chlorella sorokiniana . لم تتغير قابلية الخلية للبقاء بشكل ملحوظ في مستخلصات جرعات عالية. اكثر من %73 من الخلايا كانت قابلة للحياة في جميع تركيزات مستخلصات الطحالب. وجد بان جميع عينات الطحالب الدقيقة لها نشاط تثبيط الاغشية الحيوية. تشير النتائج الى ان التطوير المستقبلي لعينات الطحالب الدقيقة كوسيلة لتثبيط الاغشية الحيوية ل Pseudomonas aeruginosa امر ممكن. قد تصبح الخلاية الطلائية القولونية خلاية سامة استجابة لمستخلصات الطحالب. من الضروري اجراء المزيد من الابحاث للتحقق من ان المستخلصات أمنة للاستهلاك البشري, وهو ما يكون مفترضأ.

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Section: Figure 3 General Biofilm Structure Before and After The Trea...contrasting

confidence: 61%

تقييم التضاد الحيوي والنشاط السمي للخلايا من قبل الطحالب الدقيقة التي تم عزلها من مواقع مختلفة في بيتواتا- اربيل/العراق

Anwer,

Ali,

Kart

et al. 2024

Baghdad Sci.J

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“…Amongst the parameters investigated in broilers’ blood, aspartate aminotransferase (AST) was significantly decreased in the CCE-fed broilers. AST reflects the condition of liver function [ 44 ]. Overlooking the cytoprotective properties of carotenoids against liver oxidative damage by restraining or delaying the oxidation and suppressing ROS production, they are also considered precursors of retinol (vit A), which is involved in hepatic stellate cells rejuvenation, thereby, preventing the progression of fibrosis to hepatocellular carcinoma in humans [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of a Carotenoid Extract from Citrus reticulata By-Products on the Immune-Oxidative Status of Broilers

et al. 2022

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Although carotenoids generally possess antimicrobial and antioxidant properties, the in vivo synergistic action of carotenoid blends derived from plant-based by-products has not been thoroughly studied. Therefore, the carotenoid characterization and antimicrobial potential of Citrus reticulata extract as well as the impact of this carotenoid-rich extract (CCE) dietary supplementation on the performance, meat quality, and immune-oxidative status of broiler chickens were determined. One hundred and twenty one-day-old hatched chicks (Ross 308) were allocated to two dietary groups, with four replicate pens of 15 birds each. Birds were fed either a basal diet (CON) or the basal diet supplemented with 0.1% CCE (25 mg carotenoid extract included in 1 g of soluble starch) for 42 d. β-Cryptoxanthin, β -Carotene, Zeaxanthin, and Lutein were the prevailing carotenoid compounds in the Citrus reticulata extract. The CCE feed additive exerted inhibitory properties against both Gram-positive (Staphylococcus aureus) and negative (Klebsiella oxytoca, Escherichia coli, and Salmonella typhimurium) bacteria. Both the broiler performance and meat quality did not substantially differ, while the breast muscle malondialdehyde (MDA) concentration tended to decrease (p = 0.070) in the CCE-fed broilers. The inclusion of CCE decreased the alanine aminotransferase and MDA concentration, and the activity of glutathione peroxidase, while the activity of superoxide dismutase was increased in the blood. Catalase and NADPH oxidase 2 relative transcript levels were significantly downregulated in the livers of the CCE-fed broilers. Additionally, Interleukin 1β and tumor necrosis factor (TNF) relative transcript levels were downregulated in the livers of the CCE- fed broilers, while TNF and interferon γ (IFNG) tended to decrease in the spleens and bursa of Fabricius, respectively. The present study provided new insights regarding the beneficial properties of carotenoids contained in Citrus reticulata in broilers’ immune-oxidative status. These promising outcomes could be the basis for further research under field conditions.

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“…It is well established that hepatocytes are in the frontline against oxidative damage [ 45 ]. Even though growing evidence from animal and human studies suggests that C. vulgaris can be a promising hepatoprotective agent, the results are still controversial, as recently reviewed by Yarmohammadi et al [ 46 ]. Herein, none of the aminotransferases enzymes (AST and ALT) was affected by dietary inclusion of 10 % C. vulgaris , supplemented or not with both exogenous CAZymes.…”

Section: Discussionmentioning

confidence: 99%

Impact of dietary Chlorella vulgaris and carbohydrate-active enzymes incorporation on plasma metabolites and liver lipid composition of broilers

et al. 2021

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Background Chlorella vulgaris has been proposed as a sustainable green feedstock in poultry nutrition due to its ease of cultivation, minimal environmental impact and balanced nutritional composition. However, the majority of studies documents the use of C. vulgaris as a dietary supplement in broilers instead of a feed ingredient. To the best of our knowledge, no report has shown the effect of a high-level incorporation (>2 % in the diet) of C. vulgaris on plasma metabolites and hepatic lipid composition of broilers. One hundred and twenty Ross 308 male birds were housed in 40 wired-floor cages and randomly distributed by the following experimental diets at 22 days of age (n = 10) during 15 days: (1) a corn-soybean meal based diet (control); (2) based diet with 10% of C. vulgaris; (3) diet 2 supplemented with 0.005% Rovabio® Excel AP; and (4) diet 2 supplemented with 0.01% of a pre-selected four-CAZyme mixture. Results The inclusion of C. vulgaris at 10% in the diet, regardless of the presence of exogenous CAZymes, changed plasma metabolites but did not compromise broilers growth. Plasma total lipids increased in broilers fed C. vulgaris combined with the two feed CAZymes (p < 0.001) compared with the control diet. Moreover, the supplementation with Rovabio® increased total cholesterol and LDL-cholesterol, while the addition of the four-CAZyme mixture increased triacylglycerols, VLDL-cholesterol and ALP activity. In opposition, HDL-cholesterol levels decreased in broilers fed microalga alone (p = 0.002). Regarding hepatic composition, the inclusion of C. vulgaris in broiler diets, individually or combined with exogenous CAZymes, had a minor effect on fatty acids but improved the n-6/n-3 ratio and total carotenoids. Conclusions In summary, the inclusion of a high level (10%) of C. vulgaris in broiler´s diet, regardless of the presence of exogenous CAZymes, improved hepatic antioxidant composition and did not impair broiler’s performance. In addition, the feed supplementation with CAZymes increased broilers lipemia. Therefore, dietary C. vulgaris at this incorporation level seems to be safe for animal health and do not compromise performance traits, with no need of CAZymes supplementation.

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Effect of Chlorella vulgaris on Liver Function Biomarkers: a Systematic Review and Meta-Analysis

Cited by 6 publications

References 34 publications

تقييم التضاد الحيوي والنشاط السمي للخلايا من قبل الطحالب الدقيقة التي تم عزلها من مواقع مختلفة في بيتواتا- اربيل/العراق

تقييم التضاد الحيوي والنشاط السمي للخلايا من قبل الطحالب الدقيقة التي تم عزلها من مواقع مختلفة في بيتواتا- اربيل/العراق

Effect of a Carotenoid Extract from Citrus reticulata By-Products on the Immune-Oxidative Status of Broilers

Impact of dietary Chlorella vulgaris and carbohydrate-active enzymes incorporation on plasma metabolites and liver lipid composition of broilers

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