2004
DOI: 10.1016/j.neuroscience.2003.12.006
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Effect of I.C.V. injection of AT4 receptor ligands, NLE1-angiotensin IV and LVV-hemorphin 7, on spatial learning in rats

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Cited by 115 publications
(106 citation statements)
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“…Considering the wide-ranging effects mediated by IRAP and its inhibitors, understanding the genetic basis of IRAP functions is critical. In normal and memorycompromised rodent models, enhancement of memory upon intracerebroventricular delivery of AngIV and its analog peptides is the defining pharmacological property, which is thought to be mediated solely by the IRAP/AngIV binding site (Albiston et al, 2004b;Lee et al, 2004). Biochemically, these ligands show highaffinity binding to the IRAP catalytic site.…”
Section: E Distribution Of the Of Angiv Binding Sitesmentioning
confidence: 99%
“…Considering the wide-ranging effects mediated by IRAP and its inhibitors, understanding the genetic basis of IRAP functions is critical. In normal and memorycompromised rodent models, enhancement of memory upon intracerebroventricular delivery of AngIV and its analog peptides is the defining pharmacological property, which is thought to be mediated solely by the IRAP/AngIV binding site (Albiston et al, 2004b;Lee et al, 2004). Biochemically, these ligands show highaffinity binding to the IRAP catalytic site.…”
Section: E Distribution Of the Of Angiv Binding Sitesmentioning
confidence: 99%
“…13,17) But the most important correlation is, that like Ang IV, LVV-H7 facilitates memory in both normal and scopolamine treated rats. 18) Utilizing the Barnes circular maze, Ang IV and LVV-H7 were both demonstrated to facilitate memory as assessed by mean number of days to reach learner criterion. 18) In addition, like Ang IV, central administration of LVV-H7 attenuates the deleterious effects of scopolamine on memory performance, observed in rats in the two different behavioral paradigms, the swim water maze and the passive aviodance task (Albiston et al, in press).…”
Section: Angiotensin IVmentioning
confidence: 99%
“…In 2001, the hexapeptide angiotensin IV (Ang IV; Val-Tyr-IleHis-Pro-Phe), which improves memory and learning in both rats and mice (Braszko et al, 1988;Wright et al, 1993Wright et al, , 1996Wright et al, , 1999Lee et al, 2004;Gard et al, 2007Gard et al, , 2012Braszko et al, 2008;De Bundel et al, 2009), was demonstrated to inhibit the membrane-bound zinc-dependent insulin-regulated aminopeptidase (EC 3.4.11.3 IRAP,oxytocinase), a member of the M1 family, which is expressed in a diversity of tissues/cells (Albiston et al, 2001;Liao et al, 2006;Saveanu and van Endert, 2012;Nikolaou et al, 2014). There has been dispute in the field as to the target that mediates the memory-enhancing effects of Ang IV, because this hexapeptide has the ability to bind to other proteins (Vanderheyden, 2009;Kawas et al, 2012;Benoist et al, 2014;.…”
Section: Introductionmentioning
confidence: 99%