Effect of <i>Ashwagandha (Withania somnifera</i>) Root Powder Supplementation in Treatment of Hypertension

Kushwaha, Shalini; Betsy, A.; Chawla, Paramjit

doi:10.1080/09735070.2012.11886427

Cited by 24 publications

(16 citation statements)

References 4 publications

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“…somnifera has also been shown to improve resistance to stress in human subjects [ 16 ]. Root powder of the plant has been shown to reduce cholesterol, triglycerides, LDL, and VLDL in mild non-insulin-dependent diabetes mellitus and mild hypercholesterolemic human subjects [ 17 ] and to control hypertension [ 18 ]. A commercially available root extract of W .…”

Section: Introductionmentioning

confidence: 99%

Withania somnifera as a potential candidate to ameliorate high fat diet-induced anxiety and neuroinflammation

Kaur

2017

J Neuroinflammation

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BackgroundThe epidemic of obesity has reached alarming levels in both developing and developed nations. Excessive calorie intake and sedentary lifestyle due to technological advancements are the main causal factors for overweight and obesity among the human population. Obesity has been associated with a number of co-morbidities such as hypertension, type 2 diabetes mellitus, cardiovascular diseases, and neurodegeneration and dementia. The progression of neurological disorders in obese subjects has been mainly attributed to neuroinflammation. Withania somnifera has been used in numerous Ayurvedic formulations owing to its wide array of health-promoting properties. The current study was designed to test the hypothesis whether dry leaf powder of W. somnifera has anxiolytic and anti-neuroinflammatory potential in diet-induced obesity.MethodsYoung adult female rats were divided into four groups: low fat diet group (LFD) fed with regular chow feed, high fat diet group (HFD) fed with diet containing 30% fat by weight, low fat diet plus extract group (LFDE) fed with regular chow feed supplemented with dry leaf powder of W. somnifera 1 mg/g of body weight (ASH), and high fat diet plus extract group (HFDE) fed with diet containing 30% fat by weight and supplemented with ASH. All the animals were kept on respective feeding regimen for 12 weeks; following which, the animals were tested for their anxiety-like behavior using elevated plus maze test. The animals were sacrificed and used to study various inflammatory markers such as GFAP, Iba1, PPARγ, iNOS, MCP-1, TNFα, IL-1β, IL-6, and various markers of NF-κB pathway by Western blotting and quantitative real-time PCR. Serum levels of leptin, insulin and pro-inflammatory cytokines were also assayed.ResultsASH treated rats showed less anxiety levels as compared to HFD animals. At molecular level, ASH ameliorated the HFD-induced reactive gliosis and microgliosis and suppressed the expression of inflammatory markers such as PPARγ, iNOS, MCP-1, TNFα, IL-1β, and IL-6. Further, ASH ameliorated leptin and insulin resistance and prevented HFD-induced apoptosis.ConclusionsDry leaf powder of W. somnifera may prove to be a potential therapeutic agent to attenuate neuroinflammation associated with obesity and may prevent its co-morbidities.

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Section: Introductionmentioning

confidence: 99%

Withania somnifera as a potential candidate to ameliorate high fat diet-induced anxiety and neuroinflammation

Kaur

2017

J Neuroinflammation

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“…Despite many similarities in different results of humans and laboratory animals, there are significant differences that should be taken into account when designing, conducting, and interpreting animal studies. Relevant pharmaco-toxicological properties of new chemical entities have to be extensively studied in laboratory animals before human administration (Casal & Haskins, 2005;Kushwaha et al, 2012).…”

Section: Resultsmentioning

confidence: 99%

“…Thus it is used as a general tonic as well. Some studies suggest that, it may promote growth in children and improve hemoglobin level by increasing red blood cell count in adults and (Sandhu, et al, 2010) increases heart weight and glycogen in myocardium and liver representing intensification of the anabolic process (Kushwaha et al, 2012). This study was therefore undertaken to evaluate the effects of Ashwagandharista on kidney function in rats of both sexes.…”

Section: Introdutionmentioning

confidence: 99%

Effect of Ashwagandharista (Withania somnifera) on the kidney functions of male and female rats

Rahman

Hasan

Choudhuri

2019

Jahangirnagar Univ. J. Biol. Sci.

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The key objective of this present study was to analyze the effect(s) of Ashwagandharishta on the kidney functions of both male and female Albino rats. Chronic toxicity tests were also done. Following treatments the rats were observed for 51 days to know the effects of Ashwagandharishta on kidney functions considering 3 parameters such as serum urea, creatinine and uric acid. Our results failed to exhibit a significant increase in serum urea level at low dose (P<0.01), medium dose (P<0.05) and at high dose (P<0.001) in male rat groups; but with female rat groups our results showed significant increase in serum urea level at three dose levels. Regarding serum creatinine level male rats and female rats showed a trend of increase in level at different dose but effects were insignificant except medium dose in male rats (P<0.05). Regarding serum uric acid level our results failed to show a significant increase irrespective of dose. Jahangirnagar University J. Biol. Sci. 8(1): 1-7, 2019 (June)

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“…But, in Withania somnifera treated group showed significant reversal in the haematological parameters due to its antioxidant property. Similarly, lipid peroxidation amelioration by Withania somnifera and its free radical scavenging activity have been well studied [48][49][50][51][52][53] . Aloe vera and Centella asiatica in the traditional medicine of Indian Ayurveda has been widely used against heavy metals / metalloid particularly in reducing alteration in haematological and biochemical parameters 47 .…”

Section: Discussionmentioning

confidence: 99%

Withania Somnifera Protects the Haematological Alterations Caused by Sodium Arsenite in Charles Foster Rats

Kumar¹,

Ali²,

Kumar³

et al. 2013

Int. J. Res. Ayurveda Pharm.

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This study was carried out to investigate the therapeutic role of the ethanolic extract of Withania somnifera on Sodium Arsenite induced haematological alterations in rats. Oral administration of sodium arsenite at the dose of 8 mg/kg body weight daily caused haematological alterations in rats as manifested by the significant decrease in RBC's count, Haemoglobin percentage, Haematocrit, Mean Cell Volume of RBC's (MCV), Mean Cell Haemoglobin (MCH), Mean Cell Haemoglobin Concentration (MCHC) and White Blood Cell Count (WBC's) as compared with control. The Lipid peroxidation also showed elevated levels in comparison to control. But, after oral administration of ethanolic extract of Withania somnifera at the dose of 200 mg/kg body weight daily for 30 days to Sodium Arsenite pretreated rats there was an increase in the haematological parameters as well as lipid peroxidation levels decreased significantly. The study reveals that ethanolic extract of Withania somnifera possesses protective effect against haematological alterations caused by arsenic induced toxicity.

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Effect of Ashwagandha (Withania somnifera) Root Powder Supplementation in Treatment of Hypertension

Cited by 24 publications

References 4 publications

Withania somnifera as a potential candidate to ameliorate high fat diet-induced anxiety and neuroinflammation

Withania somnifera as a potential candidate to ameliorate high fat diet-induced anxiety and neuroinflammation

Effect of Ashwagandharista (Withania somnifera) on the kidney functions of male and female rats

Withania Somnifera Protects the Haematological Alterations Caused by Sodium Arsenite in Charles Foster Rats

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