“…In experimental animals, large reductions of deep body temperature (TDB) lead to elevations of the levels in the serum of enzymes associated with tissue damage [Blair, Hook, Tolly and Bunce, 1961;Russ and Lee, 1965;Zimny and Taylor, 1965]. This response is also seen in human patients in hypothermia artificially induced for surgical procedures [Rehn, Kohnlein and Brintzinger, 1961;Atanasov, 1965;Kingsley, 1966] and in accidental hypothermia [Duguid, Simpson and Stowers, 1961;Prescott, Peard and Wallace, 1962;Maclean, Griffiths and Emslie-Smith, 1968;Maclean, Murison and Griffiths, 1974].…”