Effect of Hyperventilation on the Human Electroretinogram

Alpern, Mathew; Faris, John J.; Eskildsen, P; Garnett, Peter Bj

doi:10.1126/science.121.3134.101

Cited by 16 publications

(6 citation statements)

References 10 publications

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“…This study documents that dogs have an electroretinographic hyperventilatory response similar to that described by Alpern et al (1955) and Morgan 8c Ward (1970) in humans. Using a canine animal model, we studied several variables in relation to overbreathing and its effects on the ERG.…”

Section: Discussionsupporting

confidence: 66%

“…All 8 of the dogs showed a hyperventilatory response similar to that described by Alpern et al (1955) in humans. The response consisted of a marked increase in the amplitude of the ERG b-wave after 30 sec of hyperventilation.…”

Section: Resultsmentioning

confidence: 50%

“…Alpern et al (1955) were the first to record the effect of hyperventilation on the ERG. They noted that in two hyperventilating human subjects the ERG b-wave increased in amplitude.…”

mentioning

confidence: 99%

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Physiologic Correlates of the Erg Hyperventilatory Response in Dogs

Murray

Borda

1984

Acta Ophthalmologica

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Previous studies in man have shown that hyperventilation consistently enhances the amplitude of the electroretinogram (ERG) b-wave, but has little effect on the a-wave. The present study examined this phenomenon in the dog; central (centrifugal) and peripheral (sympathetic) neural effects and changes in arterial pO2 and blood pH were excluded as physiologic bases for the phenomenon. It was concluded, therefore, that the underlying mechanism must be decreased pCO2 (hypocapnia), although the specific site of action and the method by which the ERG b-wave is enhanced remain topics for future research.

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Section: Discussionsupporting

confidence: 66%

Section: Resultsmentioning

confidence: 50%

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Physiologic Correlates of the Erg Hyperventilatory Response in Dogs

Murray

Borda

1984

Acta Ophthalmologica

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“…Likewise, there was no history or any findings suggesting causes other than connected with the neural mechanisms of the visual system for the enhancement of the retinal response, such as siderosis of the retina (KARPE, 1957), hyperventilation (ALPERN et al, 1955) or vascular disturbances (HENKES 1954). The ERG being of normal shape, i.e.…”

Section: Fig 4 the Averaged Vep To Binocular (Upper Tracej And Monocmentioning

confidence: 96%

Enhanced retinal responses without signs of optic nerve involvement

1971

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Seven patients with low visual acuity displaying enhanced positive waves in retinal responses of normal shape and reduced or extinct visual evoked potentials were presented. None of these cases exhibited any sign of optic nerve affection and visual field defects nor any localizing neurological deficits. Conclusions drawn in an earlier report from similar electrophysiological findings but obtained in cases with optic nerve atrophy were applied here. On the basis of these findings, it is hypothesized that the enhanced ERG represents the result of an abolition of a physiological rivalry between the increasing retinal sensitivity in the dark and an inhibitory cerebral influence upon retinal activity exerted via efferent fibers in the optic nerve. The possible origins of this assumed negative feedback mechanism are discussed, though neither experimental facts nor speculation did provide a reasonable clue. An answer may be given by observing the patients during the following years and possibly by animal experiments.

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“…Since then, clinical ERG recordings have confirmed the experimental finding. 4. In To demonstrate that certain drugs may prolong the viability of an isolated retina is not entirely sufficient.…”

Section: Commentmentioning

confidence: 99%

Prolonged Survival of the Isolated Retina Induced by Drugs

Apter¹

1958

AMA Arch Ophthalmol

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Effect of Hyperventilation on the Human Electroretinogram

Cited by 16 publications

References 10 publications

Physiologic Correlates of the Erg Hyperventilatory Response in Dogs

Physiologic Correlates of the Erg Hyperventilatory Response in Dogs

Enhanced retinal responses without signs of optic nerve involvement

Prolonged Survival of the Isolated Retina Induced by Drugs

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