Effect of hypertonic dialysate and vasodilators on peritoneal dialysis clearances in the rat

Brown, Edwina A.; Kliger, Alan S.; Goffinet, John A.; Finkelstein, Fredric O.

doi:10.1038/ki.1978.40

Cited by 53 publications

(8 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, local vasodilation due to vasoactivity of this drug, as with other vasoactive sub stances [11][12][13], only explains the proportional increase of small and large solute clearances, while the effect of increased permeability can be disregarded as this leads to opposite results from those of this experiment [14][15][16][17][18]. Therefore, the only possible explanation for these results is the dialysate factor.…”

Section: Discussioncontrasting

confidence: 42%

Effect of Chlorpromazine on Peritoneal Clearances

Indraprasit¹,

Sooksriwongse²

1985

Nephron

View full text Add to dashboard Cite

Chlorpromazine added to the dialysate improved the ultrafiltration and increased peritoneal clearances of urea and inulin. These results were postulated to be due to the narrowed stagnant dialysate fluid layer by the surface-active property of chlorpromazine. The study suggested another way to improve large solute (possibly uremic toxin) transport by using substances that facilitate convective transport. Intraperitoneal chlorpromazine increased the peritoneal dialysis efficiency.

show abstract

Section: Discussioncontrasting

confidence: 42%

Effect of Chlorpromazine on Peritoneal Clearances

Indraprasit¹,

Sooksriwongse²

1985

Nephron

View full text Add to dashboard Cite

show abstract

“…When vasodilators such as nitroprusside, isoproterenol, histamine, and bradykinin are added to the dialysate in animals and in man [12.21.22], the clearance of both small and large-size solutes is increased. While Nolph has found a proportion ally higher increment in large than in small-size molecules, our studies in both the rat [12] and humans [22] show a proportional increase in the clearances of small and largesize solutes. Therefore, nitroprusside may enhance peri toneal clearance by increasing the number of pores avail able for solute exchange and thereby increase the effective pore area of the membrane.…”

Section: Ways To Enhance the Efficiency Of Peritoneal Dialysismentioning

confidence: 89%

“…However, other factors are probably operating as well. In our animal studies [12], 4.25% dextrose solution resulted in enhanced urea clearance during hypertonicexchanges and. despite a fall in osmolar gradient, in the following three isotonic exchanges, suggesting that the mechanism for increased clearance is related not solely to increased convective forces, but to a change in the mem brane surface area or resistance characteristics.…”

Section: Ways To Enhance the Efficiency Of Peritoneal Dialysismentioning

confidence: 97%

Current Concepts in Peritoneal Dialysis

Kliger¹

1981

Nephron

Self Cite

View full text Add to dashboard Cite

Peritoneal dialysis has been increasingly employed to treat patients with end-stage renal failure. Solute transport can be enhanced by increasing ultrafiltration with hypertonic dialysate, infusing intraperitoneal vasodilators to increase the effective surface area for exchange, and by employing new methods of dialysate delivery which may improve dialysate mixing and decrease the effective membrane resistance to solute flux. While infection remains a major complication of peritoneal dialysis, techniques to prevent and treat infections have been effectively employed. Progress has also been made in the treatment of diabetic patients with peritoneal dialysis. Continuous ambulatory peritoneal dialysis, a relatively new technique with fast growing clinical application, may be the therapy of choice for many patients with end-stage renal failure.

show abstract

“…[31] In one study in rabbits, a adrenergic stimulus with norepinephrine decreased urea and creatinine clearance, but the authors did not mention about drainage volume. [32] b-receptor stimulus with intraperitoneal isoproterenol increased the urea and creatinine clearance in rats, [33] but did not affect drainage volume in rabbits [34] and dogs. [35] In our study, the use of carvedilol, an antagonist of a1-and b-adrenergic receptors, had no significant effect on D/P cr ratio at 0, 2, and 4 hours; D/Do glucose ratios at 2 and 4 hours; and UF.…”

Section: Discussionmentioning

confidence: 99%

Comparative Effects of Carvedilol and Lercanidipine on Ultrafiltration and Solute Transport in CAPD Patients

Topal¹,

Erkoç

Sayarlıoğlu

et al. 2009

Renal Failure

View full text Add to dashboard Cite

Background. Peritonitis, the type of buffer used in the dialysate, continue ambulatory peritoneal dialysis (CAPD) of greater than two years duration, increased exposure to dialysate glucose, diabetes mellitus, and the use of beta blockers may contribute to impaired ultrafiltration. Objectives. The aim of the present study is to compare the effects of a calcium-channel blocker and a b-blocker on the peritoneal transport and clearance. Methods. We studied 48 patients with ESRD on chronic peritoneal dialysis, included 27 females and 19 males with mean age 42.6 ± 16.4 years. Two patients were excluded from the study due to peritonitis. Patients were treated either with carvedilol or lercanidipine. In all patients; peritoneal equilibration test (PET), ultrafiltration (UF), Kt/V ratio, creatinine clearance (CrCl), systolic blood pressure, diastolic blood pressure, serum BUN, creatinine, glucose, sodium, potassium, albumin, cholesterol, and triglyceride values were obtained before and after 8 weeks from the start of the drug treatment. Results. Lercanidipine and carvedilol showed a good antihypertensive effect in CAPD patients. Both drugs had a good tolerability profile and showed no effect on plasma lipids. There were no differences in terms of PET, ultrafiltration, Kt/V ratio, CrCl, systolic blood pressure, diastolic blood pressure, serum BUN, creatinine, glucose, sodium, and potassium values between both patient groups. After antihypertensive treatment, neither group showed a difference in the above-mentioned parameters (p > 0.05) except potassium, which was significantly higher in the carvedilol group (p < 0.05). Conclusions. In CAPD patients. short-term usage of carvedilol has no effect on ultrafiltration and solute transport like lercanidipine. Both drugs showed a good antihypertensive effect.

show abstract

Effect of hypertonic dialysate and vasodilators on peritoneal dialysis clearances in the rat

Cited by 53 publications

References 10 publications

Effect of Chlorpromazine on Peritoneal Clearances

Effect of Chlorpromazine on Peritoneal Clearances

Current Concepts in Peritoneal Dialysis

Comparative Effects of Carvedilol and Lercanidipine on Ultrafiltration and Solute Transport in CAPD Patients

Contact Info

Product

Resources

About