Effect of hyperoxia on maximal O2 uptake in exercise-induced arterial hypoxaemic subjects

Grataloup, O.; Prieur, Fabrice; Busso, Thierry; Castells, J.; Favier, F.; Denis, Christian; Benoît, H.

doi:10.1007/s00421-005-1361-0

Cited by 18 publications

(15 citation statements)

References 32 publications

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“…The modest increase in W max under hyperoxia found in the current study is in line with previous studies performed mostly in young athletes breathing oxygen- enriched air with various fractions of O 2 of 0.3-1.0 [11,17,18,19,20,21]. Our data extend these findings by showing a similar effect of hyperoxia on exercise performance in nonathletic - albeit relatively fit - subjects of both genders and of a broad age range (24-66 years).…”

Section: Discussionsupporting

confidence: 81%

Mechanisms of Improved Exercise Performance under Hyperoxia

Ulrich¹,

Hasler²,

Müller-Mottet³

et al. 2017

Respiration

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Background: The impact of hyperoxia on exercise limitation is still incompletely understood. Objectives: We investigated to which extent breathing hyperoxia enhances the exercise performance of healthy subjects and which physiologic mechanisms are involved. Methods: A total of 32 healthy volunteers (43 ± 15 years, 12 women) performed 4 bicycle exercise tests to exhaustion with ramp and constant-load protocols (at 75% of the maximal workload [W_max] on FiO₂ 0.21) on separate occasions while breathing ambient (FiO₂ 0.21) or oxygen-enriched air (FiO₂ 0.50) in a random, blinded order. Workload, endurance, gas exchange, pulse oximetry (SpO₂), and cerebral (CTO) and quadriceps muscle tissue oxygenation (QMTO) were measured. Results: During the final 15 s of ramp exercising with FiO₂ 0.50, W_max (mean ± SD 270 ± 80 W), SpO₂ (99 ± 1%), and CTO (67 ± 9%) were higher and the Borg CR10 Scale dyspnea score was lower (4.8 ± 2.2) than the corresponding values with FiO₂ 0.21 (W_max 257 ± 76 W, SpO₂ 96 ± 3%, CTO 61 ± 9%, and Borg CR10 Scale dyspnea score 5.7 ± 2.6, p < 0.05, all comparisons). In constant-load exercising with FiO₂ 0.50, endurance was longer than with FiO₂ 0.21 (16 min 22 s ± 7 min 39 s vs. 10 min 47 s ± 5 min 58 s). With FiO₂ 0.50, SpO₂ (99 ± 0%) and QMTO (69 ± 8%) were higher than the corresponding isotime values to end-exercise with FiO₂ 0.21 (SpO₂ 96 ± 4%, QMTO 66 ± 9%), while minute ventilation was lower in hyperoxia (82 ± 18 vs. 93 ± 23 L/min, p < 0.05, all comparisons). Conclusion: In healthy subjects, hyperoxia increased maximal power output and endurance. It improved arterial, cerebral, and muscle tissue oxygenation, while minute ventilation and dyspnea perception were reduced. The findings suggest that hyperoxia enhanced cycling performance through a more efficient pulmonary gas exchange and a greater availability of oxygen to muscles and the brain (cerebral motor and sensory neurons).

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Section: Discussionsupporting

confidence: 81%

Mechanisms of Improved Exercise Performance under Hyperoxia

Ulrich¹,

Hasler²,

Müller-Mottet³

et al. 2017

Respiration

View full text Add to dashboard Cite

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“…At SL, EIH is already known to negatively affect VO 2max [8] and subsequently exercise performance [10]. In this study at 2150 m, EIH athletes demonstrated a higher decline in VO 2max from SL than non-EIH athletes.…”

Section: Discussionmentioning

confidence: 54%

“…“EIH athletes” show a difference between rest and maximal arterial O 2 pressure (PaO 2 ) values for at least 10 mmHg and/or a delta of SaO 2 of at least 4% [9]. It is reported that EIH subsequently affects performance in response to high intensity exercise [10]. Physiopathology of EIH seems to be 1) a relative hypoventilation related to training adaptation and 2) gas exchange abnormality [11].…”

Section: Introductionmentioning

confidence: 99%

Exercise-Induced Hypoxaemia Developed at Sea-Level Influences Responses to Exercise at Moderate Altitude

et al. 2016

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PurposeThe aim of this study was to investigate the impact of exercise-induced hypoxaemia (EIH) developed at sea-level on exercise responses at moderate acute altitude.MethodsTwenty three subjects divided in three groups of individuals: highly trained with EIH (n = 7); highly trained without EIH (n = 8) and untrained participants (n = 8) performed two maximal incremental tests at sea-level and at 2,150 m. Haemoglobin O2 saturation (SpO2), heart rate, oxygen uptake (VO2) and several ventilatory parameters were measured continuously during the tests.ResultsEIH athletes had a drop in SpO2 from 99 ± 0.8% to 91 ± 1.2% from rest to maximal exercise at sea-level, while the other groups did not exhibit a similar decrease. EIH athletes had a greater decrease in VO2max at altitude compared to non-EIH and untrained groups (-22 ± 7.9%, -16 ± 5.3% and -13 ± 9.4%, respectively). At altitude, non-EIH athletes had a similar drop in SpO2 as EIH athletes (13 ± 0.8%) but greater than untrained participants (6 ± 1.0%). EIH athletes showed greater decrease in maximal heart rate than non-EIH athletes at altitude (8 ± 3.3 bpm and 5 ± 2.9 bpm, respectively).ConclusionEIH athletes demonstrated specific cardiorespiratory response to exercise at moderate altitude compared to non-EIH athletes with a higher decrease in VO2max certainly due to the lower ventilator and HRmax responses. Thus EIH phenomenon developed at sea-level negatively impact performance and cardiorespiratory responses at acute moderate altitude despite no potentiated O2 desaturation.

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“…In a systematic review of the literature, we identified four randomized-controlled trials, which included a least eight subjects and provided data on the effect of hyperoxia vs. normoxia air on maximal exercise performance in terms of workload or V O 2 (Table A2). All revealed an increased workload of V O 2 under hyperoxia (20,42,48,68).…”

Section: Effect Of Hyperoxia On Exercise Performance In Healthy Indivmentioning

confidence: 96%

Effect of hypoxia and hyperoxia on exercise performance in healthy individuals and in patients with pulmonary hypertension: a systematic review

Ulrich

Schneider

Bloch

2017

Journal of Applied Physiology

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Exercise performance is determined by oxygen supply to working muscles and vital organs. In healthy individuals, exercise performance is limited in the hypoxic environment at altitude, when oxygen delivery is diminished due to the reduced alveolar and arterial oxygen partial pressures. In patients with pulmonary hypertension, exercise performance is already reduced near sea level due to impairments of the pulmonary circulation and gas exchange and, presumably, these limitations are more pronounced at altitude. In studies performed near sea level in healthy subjects as well as in patients with pulmonary hypertension (PH) maximal performance during progressive ramp exercise and endurance of submaximal constant load exercise were substantially enhanced by breathing oxygen-enriched air. Both in healthy individuals and in PH-patients these improvements were mediated by a better arterial, muscular and cerebral oxygenation along with a reduced sympathetic excitation, as suggested by the reduced heart rate and alveolar ventilation at submaximal isoloads, and an improved pulmonary gas exchange efficiency, especially in patients with PH. In summary, in healthy individuals and in patients with pulmonary hypertension, alterations in the inspiratory PO2 by exposure to hypobaric hypoxia or normobaric hyperoxia reduce or enhance exercise performance, respectively, by modifying oxygen delivery to the muscles and the brain, by effects on cardiovascular and respiratory control and by alterations in pulmonary gas exchange. The understanding of these physiologic mechanisms helps counselling individuals planning altitude or air travel and prescribing oxygen therapy to patients with pulmonary hypertension. is determined by oxygen supply to working muscles and vital organs. In healthy individuals, exercise performance is limited in the hypoxic environment at altitude, when oxygen delivery is diminished due to the reduced alveolar and arterial oxygen partial pressures. In patients with pulmonary hypertension (PH), exercise performance is already reduced near sea level due to impairments of the pulmonary circulation and gas exchange, and, presumably, these limitations are more pronounced at altitude. In studies performed near sea level in healthy subjects, as well as in patients with PH, maximal performance during progressive ramp exercise and endurance of submaximal constant-load exercise were substantially enhanced by breathing oxygen-enriched air. Both in healthy individuals and in PH patients, these improvements were mediated by a better arterial, muscular, and cerebral oxygenation, along with a reduced sympathetic excitation, as suggested by the reduced heart rate and alveolar ventilation at submaximal isoloads, and an improved pulmonary gas exchange efficiency, especially in patients with PH. In summary, in healthy individuals and in patients with PH, alterations in the inspiratory PO 2 by exposure to hypobaric hypoxia or normobaric hyperoxia reduce or enhance exercise performance, respectively, by modifying oxygen deliv...

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Effect of hyperoxia on maximal O2 uptake in exercise-induced arterial hypoxaemic subjects

Cited by 18 publications

References 32 publications

Mechanisms of Improved Exercise Performance under Hyperoxia

Mechanisms of Improved Exercise Performance under Hyperoxia

Exercise-Induced Hypoxaemia Developed at Sea-Level Influences Responses to Exercise at Moderate Altitude

Effect of hypoxia and hyperoxia on exercise performance in healthy individuals and in patients with pulmonary hypertension: a systematic review

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