Effect of hyperlipidemia on 11β-hydroxysteroid-dehydrogenase, glucocorticoid receptor, and leptin expression in insulin-sensitive tissues of cats

Sieber-Ruckstuhl, Nadja S; Zini, Eric; Osto, Melania; Franchini, Marco; Boretti, Felicitas S; Meli, Marina L.; Sigrist, Brigitte; Lutz, Thomas; Reusch, Claudia E

doi:10.1016/j.domaniend.2010.06.003

Cited by 4 publications

(3 citation statements)

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“…Glucocorticoid receptor expression was also decreased in both fat depots (expression approximately one-sixth of control in subcutaneous adipose and expression approximately one-fifth of control in visceral adipose), which may indicate a tissue defense mechanism against the rise of cortisol concentrations in response to the upregulation of 11β-HSD-1 and downregulation of 11β-HSD-2. In contrast, serum cortisol concentrations of lipid-infused cats were similar to the control group (Sieber-Ruckstuhl et al, 2010).…”

Section: Feline Studiesmentioning

confidence: 66%

“…Despite an increase in inflammatory processes, insulin sensitivity in lipid-infused cats was not impaired when compared with saline-infused cats, probably due to the protective effect of increased plasma circulating concentrations of adiponectin and upregulation of transcription of GLUT4 in visceral (1.54 vs. 0.82 AU) and subcutaneous (1.48 vs. 0.49 AU) depots and PPARγ2 in the subcutaneous (2.19 vs. 0.98 AU) adipose tissues (Zini et al, 2010). Another study from that same laboratory investigated the influence of hyperlipidemia on cortisol metabolism in insulin-sensitive tissues (Sieber-Ruckstuhl et al, 2010). Similar to the aforementioned study, healthy adult cats were subjected to a hyperlipidemic clamp for 10 d followed by biopsy samples of adipose (subcutaneous and visceral depots), muscle, and hepatic tissues for determination of gene expression of 11β-HSD-1 and -2 and glucocorticoid receptor by RT-PCR.…”

Section: Feline Studiesmentioning

confidence: 99%

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COMPANION ANIMALS SYMPOSIUM: Nutrigenomics: Using gene expression and molecular biology data to understand pet obesity1

Godoy

Swanson

2013

Journal of Animal Science

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Approximately 55% of dogs and 53% of cats in the United States are considered overweight or obese. The domestication of dogs and cats and, more recently, their anthropomorphism, have drastically changed their environment and social behavior. A greater manifestation of chronic diseases is observed with pet obesity (e.g., insulin resistance, type-2 diabetes, musculoskeletal disorders). The advances in "omics" technology may provide new tools to investigate the complexity of obesity and its comorbidities. The field of nutrigenomics focuses specifically on the mechanisms by which nutrients and dietary bioactive molecules affect gene expression. The main objective of this review is to discuss factors involved in the etiology of pet obesity and demonstrate how the field of nutrigenomics has been used to better understand and characterize this disease. Currently, most of the genomics literature available on companion animal obesity has focused on adipose tissue, with fewer studies focused on other tissues (e.g., skeletal muscle, liver). Initial studies focused on the sequence and functionality of a few specific genes, such as leptin and adiponectin, and identified their association with obesity. Subsequent studies focused on gene expression levels across tissues and how they were impacted by BW status or if animals were intact, spayed, or neutered. Dietary interventions to induce obesity, promote BW loss, or alter dietary nutrient profile have also been investigated. Diets including prebiotics, green tea extract, or increased concentrations of protein have been shown to modify the expression of several genes related to glucose and lipid metabolism in adipose [e.g., uncoupling protein-2, carnitine palmitoyltransferase-1, PPARα, lipoprotein lipase (LPL), and glucose transporter 4] and skeletal muscle (e.g., PPARα and LPL) tissues. In general, the outcomes derived from these studies demonstrated that dogs and cats share similar adipokines and hormones to other species, and they are affected in a similar fashion during obesity. They also indicate that gene transcription modifications may preclude clinical signs, which may become a useful tool in the management and prevention of obesity.

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Section: Feline Studiesmentioning

confidence: 66%

Section: Feline Studiesmentioning

confidence: 99%

COMPANION ANIMALS SYMPOSIUM: Nutrigenomics: Using gene expression and molecular biology data to understand pet obesity1

Godoy

Swanson

2013

Journal of Animal Science

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“…Correlations between increased leptin levels and increased BCS and body fat mass have been demonstrated in cats (44,58,(78)(79)(80)(87)(88)(89). Leptin levels are not dependent on the sex of the animal (88).…”

Section: Adipokinementioning

confidence: 98%

Adipokines as potential biomarkers for type 2 diabetes mellitus in cats

Sierawska

Niedźwiedzka-Rystwej²

2022

Front. Immunol.

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Type 2 diabetes mellitus (T2DM) is no longer only a disease of humans, but also of domestic animals, and it particularly affects cats. It is increasingly thought that because of its unique characteristics, T2DM may belong not only to the group of metabolic diseases but also to the group of autoimmune diseases. This is due to the involvement of the immune system in the inflammation that occurs with T2DM. Various pro- and anti-inflammatory substances are secreted, especially cytokines in patients with T2DM. Cytokines secreted by adipose tissue are called adipokines, and leptin, adiponectin, resistin, omentin, TNF-α, and IL-6 have been implicated in T2DM. In cats, approximately 90% of diabetic cases are T2DM. Risk factors include older age, male sex, Burmese breed, presence of obesity, and insulin resistance. Diagnosis of a cat requires repeated testing and is complicated compared to human diagnosis. Based on similarities in the pathogenesis of T2DM between humans and cats, adipokines previously proposed as biomarkers for human T2DM may also serve in the diagnosis of this disease in cats.

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