Effect of hyperbaric oxygenation on random rat skin flaps vascularization

Rech, Fabrício Valandro; Simões, Ricardo Santos; Pires, Jefferson André; Florencio‐Silva, Rinaldo; Fagundes, Djalma José

doi:10.1590/acb360906

Cited by 2 publications

(1 citation statement)

References 37 publications

(46 reference statements)

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“…HBOT was linked to an increase in blood vessel growth and viability in random rat skin flaps in an experimental study by Rech et al [20] to evaluate the impact of HBOT on angiogenesis in rat skin flaps by immunoexpression of vascular endothelial growth factor A (VEGF-A). This finding paves the way for further research to confirm and clarify the mechanism of action.…”

Section: Discussionmentioning

confidence: 99%

Hyperbaric Oxygen Therapy for Soft Tissue Injury in Open Musculoskeletal Trauma: A Prospective Study

Raj,

Bhartiya,

Rajput

et al. 2023

Cureus

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BackgroundNon-union, chronic pain, functional disability, and infection are all things that have been associated with open fractures with severe soft tissue damage leading to the need for additional hospitalization, and sometimes even subsequent surgeries and weeks or months of rehabilitation. Open fractures and severe musculoskeletal injuries are occasionally treated with hyperbaric oxygen therapy (HBOT) in an effort to reduce the risk of complications and increase the likelihood of a successful recovery. MethodsA prospective randomized controlled study was done between January 2019 and August 2022 at a tertiary health care center including 60 patients with a severe soft tissue injury (Grade II and III) divided into two groups -group-CT (30 patients who received conventional treatment) and group HT (30 patients, who received HBOT in addition to conventional treatment). The outcome was measured according to the Bates-Jensen Wound Assessment Tool. ResultsThe wound size, depth, and granulation were significantly reduced in group-HT patients. In the final session, the patient's severity of the wound in group-HT was significantly reduced (P = 0.0001) compared to group-CT. ConclusionsPatients who received HBOT reported a significant improvement in their wounds.

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Section: Discussionmentioning

confidence: 99%