Effect of hyperbaric oxygen treatment on incorporation of an autogenous cancellous bone graft in a nonunion diaphyseal ulnar defect in cats

Kerwin, Sharon C.; Lewis, D. D.; Elkins, A. D.; Oliver, Jean; Hosgood, Giselle; Pechman, R. D.; Dial, S. L.; Strain, George M.

doi:10.2460/ajvr.2000.61.691

Cited by 19 publications

(15 citation statements)

References 32 publications

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“…To our knowledge, very limited data exists on the influence of hyperbaric oxygenation on bone regeneration with the use of bone grafts . ; Investigating the effects of HBO treatment on bone regeneration in combination with the use of autologous cancellous bone grafts in diaphyseal ulnar defects in cats Kervwin et al treated the experimental group with ambient pressures of two ATM for 14 days before sacrificing the animals at five weeks.…”

Section: Discussionmentioning

confidence: 99%

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Hyperbaric oxygen therapy improves angiogenesis and bone formation in critical sized diaphyseal defects

Schneppendahl

et al. 2015

Journal Orthopaedic Research

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Besides the use of autologous bone grafting several osteoconductive and osteoinductive methods have been reported to improve bone healing. However, persistent non-union occurs in a considerable number of cases and compromised angiogenesis is suspected to impede bone regeneration. Hyperbaric oxygen therapy (HBO) improves angiogenesis. This study evaluates the effects of HBO on bone defects treated with autologous bone grafting in a bone defect model in rabbits. Twenty-four New-Zealand White Rabbits were subjected to a unilateral critical sized diaphyseal radius bone defect and treated with autologous cancellous bone transplantation. The study groups were exposed to an additional HBO treatment regimen. Bone regeneration was evaluated radiologically and histologically at 3 and 6 weeks, angiogenesis was assessed by immunohistochemistry at three and six weeks. The additional administration of HBO resulted in a significantly increased new bone formation and angiogenesis compared to the sole treatment with autologous bone grafting. These results were apparent after three and six weeks of treatment. The addition of HBO therapy to autologous bone grafts leads to significantly improved bone regeneration. The increase in angiogenesis observed could play a crucial role for the results observed. ß

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Section: Discussionmentioning

confidence: 99%

“…However, data on the influence of HBO on the osteointegration of autologous grafts in bone defects is still inconclusive . ; …”

mentioning

confidence: 99%

Hyperbaric oxygen therapy improves angiogenesis and bone formation in critical sized diaphyseal defects

Schneppendahl

et al. 2015

Journal Orthopaedic Research

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“…Although there is no direct evidence that hyperbaric normoxia improves fracture union, animal studies suggest that hyperbaric oxygen may improve bone healing. 7 Additionally, although activity in lower limbs has been shown to improve healing, it could be argued that this increased versatility could lead to worse outcomes due to the risk of reinjury. There remains no evidence in this case or in the literature to contraindicate careful return to activities or sports.…”

Section: Discussionmentioning

confidence: 99%

Cast Adrift: Gortex Cast Liners Allow Greater Patient Activity☆

Dubowitz

Miller

2003

Wilderness & Environmental Medicine

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“…Isso ocorre devido à rápida revascularização, permitindo um bom contato entre o leito receptor e o enxerto. KERWIN et al (2000) induziram defeitos, com potencial para não-união, na diáfise ulnar direita e esquerda, de 12 gatos adultos. Após 20 dias, um dos defeitos ósseos foi tratado com enxerto esponjoso autólogo colhido da porção proximal do úmero e seis gatos receberam oxigênio hiperbárico por 90 minutos, uma vez ao dia, por 14 dias.…”

Section: Cuidadosunclassified