Effect of Hyperbaric Oxygen Therapy Combined with Golden Sea Cucumber (Stichopus hermanii Powder to the Level Of Blood Glucose Diabetic Wistar Rat Induced Porphyromonas gingivalis

Abstract

<p><strong><em>Background: </em></strong><em>Diabetes mellitus (DM) is a metabolic disorders characterized by hyperglycemia caused by oxidative stress. Porphyromonas gingivalis (P.g) is a periodontopathogen caused periodontitis exacerbate blood glucose levels (BGL). Hyperbaric oxygen therapy (HBOT) combined with stichopus hermanii (SH) has a role as an antioxidant and antibacterial agent. <strong>Purpopse: </strong>To analysis effect of HBOT, SH powder and combination of both to the level of blood glucose diabetic Wistar rat induced P.g. <strong>Materials and Methods: </strong>This study was pre-test-post-test control group design, using 20 male Wistar rat were divided into 5 groups, Group1 (STZ), Group2 (STZ+P.g), Group3 (STZ+P.g+HBOT), Group4 (STZ+P.g+SH powder), Group5 (STZ+P.g+HBO+SH). STZ induction intravenous for 4 days in a row. P.g. induction was exposure 3 times for 4 days. After therapy (7 days),</em> <em>sample blood tail vein of rat were taken for measure BGL by glucometer.<strong> Result: </strong>Level of blood glucose<strong> </strong>K1(</em><em>280.25±88.786)mg/dl, K2(372.25±135.662)mg/dl, K3(249.50±96.652)mg/dl, K4(172.00±82.077)mg/dl, K5(104.75±38.257)mg/dl. <strong>Conclusion:</strong> Induction of STZ increased the BGL but induction of P.g. cannot exacerbate BGL . HBOT combined with SH powder can reduce BGL in STZ and P.g. induction group.</em></p><p><strong><em>Keywords: </em></strong><em>Diabetes mellitus, periodontitis, blood glucose levels, Stichopus hermanii, hyperbaric oxygen.</em></p><p><strong><em>Correspondence:</em></strong><strong><em> </em></strong><em>Yoifah Rizka, Department of </em><em>Periodontology</em><em>, Faculty of Dentistry, Hang Tuah University, Arif Rahman Hakim 150, Surabaya, Phone 031-5945864, 5912191, E</em><em>mail address: <a href="mailto:yoi.riez@yahoo.co.id">yoi.riez@yahoo.co.id</a></em></p>