Effect of hyperbaric oxygen on patients with traumatic brain injury

Lin, Jia‐Wei; Tsai, Jui Chen; Lee, Liang‐Ming; Lin, Chien-Min; Hung, Chung-Chan; Hung, Kuo‐Sheng; Chen, Wei-Yu; Li, Wei; Ko, Ching-Lung; Su, Y. K.; Chiu, Wen-Ta

doi:10.1007/978-3-211-78205-7_25

Cited by 41 publications

(34 citation statements)

References 9 publications

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“…A study of HBO therapy used to treat sub-acute moderate to severe TBI at 2.0 ATA reported a 9% seizure rate (75). However, serious side effects from HBO therapy are rare in patients with chronic and mild TBI and a previous study demonstrated that patients with TBI treated with HBO do not experience any marked side effects (76).…”

Section: Discussionmentioning

confidence: 99%

Effect of hyperbaric oxygenation therapy on post‑concussion syndrome (Review)

Dong

et al. 2018

Exp Ther Med

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The present review evaluated the effect of hyperbaric oxygenation (HBO) therapy on post-concussion syndrome (PCS). Searches for publications from the earliest date possible up until the first week of 2016 were conducted using the electronic databases Cochrane, EBSCOhost, Embase, Ovid MEDLINE, PubMed and Web of Science. Additional trials were identified through reference list scanning. Randomized controlled trials assessing the effectiveness of HBO therapy in PCS were selected and tested for eligibility for inclusion in the present review. Two independent reviewers conducted data extraction and the Cochrane Collaboration's recommended method was used to assess the risk of bias in each study included. Review Manager 5.3 software was used for data synthesis and analysis and the standardized mean difference (SMD) or mean difference (MD) was estimated with a fixed or random effects model using a 95% confidence interval (CI). A total of 127 articles were identified, 4 of which were eligible for final analysis. The meta-analysis identified no difference in the Rivermead Post-Concussion Symptoms Questionnaire (MD=1.23; 95% CI, −3.47-5.94; P>0.05; I2=35%) or Post-Traumatic Stress Disorder Checklist (PCL) scores (SMD=0.12; 95% CI, −0.31-0.54; P>0.05; I2=0%) scores between groups receiving different oxygen doses. The differences in PCL scores (SMD=−0.13, 95% CI, −0.80-0.53; P>0.05; I2=63%) and neurobehavioral symptoms (SMD=−1.00, 95% CI, −2.58-0.58; P>0.05; I2=92%) between the HBO and sham groups were not significant. The current study demonstrated that HBO therapy has no significant effect on PCS compared with the sham group. Therefore, it was determined that effective design and execution of a large clinical trial, which includes treatment, control and sham groups is required in the future.

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Section: Discussionmentioning

confidence: 99%

Effect of hyperbaric oxygenation therapy on post‑concussion syndrome (Review)

Dong

et al. 2018

Exp Ther Med

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“…Additional sites included a naval medicine operational training center,17,18 the US Air Force School of Aerospace Medicine,19,20 and a hyperbaric institute and research unit of a medical center 23. Two studies did not describe the study location 24,26. Ten of the 12 studies included details of equipment used to some extent; this mostly entailed describing the type of HBO 2 chamber used.…”

Section: Resultsmentioning

confidence: 99%

“…Ten of the 12 studies included details of equipment used to some extent; this mostly entailed describing the type of HBO 2 chamber used. Five studies used multiplace,17–22,26,29,60 and 3 used monoplace chambers 25,30,32. An additional study placed some subjects in a multiplace chamber and others in a monoplace chamber 28.…”

Section: Resultsmentioning

confidence: 99%

“…One study compared HBO 2 with no HBO 2 treatment 26. Six other studies compared HBO 2 with various forms of “standard care,”24,25,27–29,31,32 one of which was a 3-armed study comparing HBO 2 with “standard care” to normobaric hyperoxia 28.…”

Section: Resultsmentioning

confidence: 99%

“…Four studies involved outcome measures of consciousness24,26,27,29,31; 5 utilized the Glasgow Outcomes Scale (GOS) and/or measures of mortality24–27,31; and 2 involved intracranial pressure (ICP) 25,28. In all 3 acceptable (+) quality studies reporting on consciousness, the HBO 2 groups experienced statistically significant better recovery compared with “standard care” ( n = 2) and no HBO 2 treatment ( n = 1).…”

Section: Resultsmentioning

confidence: 99%

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Is Hyperbaric Oxygen Therapy Effective for Traumatic Brain Injury? A Rapid Evidence Assessment of the Literature and Recommendations for the Field

Crawford

Teo

Yang

et al. 2017

Journal of Head Trauma Rehabilitation

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Hyperbaric oxygen therapy for the adjunctive treatment of traumatic brain injury

Bennett¹,

Trytko²,

Jonker³

2004

Cochrane Database of Systematic Reviews

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In people with traumatic brain injury, the addition of HBOT significantly reduced the risk of death but not of favourable clinical outcome. The routine application of HBOT to these patients cannot be justified from this review. In view of the modest number of patients, methodological shortcomings and poor reporting, this result should be interpreted cautiously, and an appropriately powered trial of high methodological rigour is justified to define those patients (if any) who can be expected to derive most benefit from HBOT.

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Effect of hyperbaric oxygen on patients with traumatic brain injury

Cited by 41 publications

References 9 publications

Effect of hyperbaric oxygenation therapy on post‑concussion syndrome (Review)

Effect of hyperbaric oxygenation therapy on post‑concussion syndrome (Review)

Is Hyperbaric Oxygen Therapy Effective for Traumatic Brain Injury? A Rapid Evidence Assessment of the Literature and Recommendations for the Field

Hyperbaric oxygen therapy for the adjunctive treatment of traumatic brain injury

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