Effect of hydroxyurea exposure before puberty on sperm parameters in males with sickle cell disease

Joseph, Laure; Jean, Christian; Manceau, Sandra; Chalas, Céline; Arnaud, Cécile; Kamdem, Annie; Pondarré, Corinne; Habibi, Anoosha; Bernaudin, Françoise; Allali, Slimane; Montalembert, Mariane de; Boutonnat-Faucher, Bénédicte; Arlet, J; Koehl, Bérengère; Cavazzana, Marina; Ribeil, Jean‐Antoine; Lionnet, François; Berthaut, Isabelle; Brousse, Valentine

doi:10.1182/blood.2020006270

Cited by 34 publications

(43 citation statements)

References 9 publications

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Section: Hypoxic Factors Causing Male Infertilitymentioning

confidence: 99%

“…Interestingly, a case report indicated that sickle cell disease caused repeat testicular infarction ( Li et al, 2003 ). In addition, several studies have reported that hypogonadism and poor sperm parameters including low sperm counts, impaired motility of spermatozoa and increased abnormal sperm morphology occur frequently in male patients with sickle cell disease ( Nahoum et al, 1980 ; Osegbe et al, 1981 ; Grigg, 2007 ; Berthaut et al, 2008 ; Joseph et al, 2021 ). Surprisingly, priapism and impotence occur frequently in patients with SCD, with an incidence up to 50% ( Emond et al, 1980 ; Adeyoju et al, 2002 ; Nolan et al, 2005 ; Madu et al, 2014 ; Salonia et al, 2014 ; Chinegwundoh et al, 2017 , 2020 ).…”

Section: Hypoxic Factors Causing Male Infertilitymentioning

confidence: 99%

“…The heart pumps oxygenated blood to the periphery, which is crucial for organs and cells to function and perform oxidative phosphorylation. Cardiovascular and hematological disorders can cause a decrease in blood oxygen carrying capacity or blood circulation capacity, resulting in hypoxia (Joseph et al, 2021). Sickle cell disease (SCD) is one of the most common, inherited hematological diseases caused by a single amino acid substitution (GTG for GAG) in the gene encoding hemoglobin β (Papageorgiou et al, 2018).…”

Section: Hematological Diseasesmentioning

confidence: 99%

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Effects of Environmental and Pathological Hypoxia on Male Fertility

Wang

Gong

et al. 2021

Front. Cell Dev. Biol.

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Male infertility is a widespread health problem affecting approximately 6%–8% of the male population, and hypoxia may be a causative factor. In mammals, two types of hypoxia are known, including environmental and pathological hypoxia. Studies looking at the effects of hypoxia on male infertility have linked both types of hypoxia to poor sperm quality and pregnancy outcomes. Hypoxia damages testicular seminiferous tubule directly, leading to the disorder of seminiferous epithelium and shedding of spermatogenic cells. Hypoxia can also disrupt the balance between oxidative phosphorylation and glycolysis of spermatogenic cells, resulting in impaired self-renewal and differentiation of spermatogonia, and failure of meiosis. In addition, hypoxia disrupts the secretion of reproductive hormones, causing spermatogenic arrest and erectile dysfunction. The possible mechanisms involved in hypoxia on male reproductive toxicity mainly include excessive ROS mediated oxidative stress, HIF-1α mediated germ cell apoptosis and proliferation inhibition, systematic inflammation and epigenetic changes. In this review, we discuss the correlations between hypoxia and male infertility based on epidemiological, clinical and animal studies and enumerate the hypoxic factors causing male infertility in detail. Demonstration of the causal association between hypoxia and male infertility will provide more options for the treatment of male infertility

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Section: Hypoxic Factors Causing Male Infertilitymentioning

confidence: 99%

Section: Hypoxic Factors Causing Male Infertilitymentioning

confidence: 99%

Section: Hematological Diseasesmentioning

confidence: 99%

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Effects of Environmental and Pathological Hypoxia on Male Fertility

Wang

Gong

et al. 2021

Front. Cell Dev. Biol.

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“…107,108 Fertility pres er va tion pro ce dures preHCT must also con sider that HU may cause gonadal dam age and have an adverse impact on male and female fer til ity in SCD patients. 109,110 Med ic aid cov er age of fer til ity pres er va tion is extremely lim ited both in the scope of ben e fits and the num ber of states that require such a ben e fit. 111 For exam ple, only 15 states require fer til ity pres er va tion cov er age in pri vate insur ance plans, and 5 states extend this ben e fit only to females.…”

Section: Gonadal Dam Age and Impaired Fer Til Itymentioning

confidence: 99%

Hematopoietic cell transplantation for sickle cell disease: updates and future directions

Krishnamurti

2021

Hematology

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Excellent outcomes in hematopoietic cell transplantation (HCT) from HLA-identical siblings, improvements in conditioning regimens, novel graft-versus-host disease prophylaxis, and the availability of alternative donors have all contributed to the increased applicability and acceptability of HCT for sickle cell disease (SCD). In young children with symptomatic SCD with an available HLA-identical related donor, HCT should be carefully considered. HCT from alternative donors is typically undertaken only in patients with severe symptoms, causing or likely to cause organ damage, and in the context of clinical trials. Patients undergoing HCT for SCD require careful counseling and preparation. They require careful monitoring of unique organ toxicities and complications during HCT. Patients must be prospectively followed for a prolonged time to determine the long-term outcomes and late effects of HCT for SCD. Thus, there is a need for a universal, longitudinal clinical registry to follow patients after HCT for SCD in conjunction with individuals who do not receive HCT to compare outcomes. Antibody-based conditioning and ex-vivo umbilical cord blood expansion are likely to improve the availability and acceptability of HCT. In addition, new disease-modifying drugs and the emerging option of the autologous transplantation of gene-modified hematopoietic progenitor cells are likely to expand the available therapeutic options and make decision-making by patients, physicians, and caregivers even more complicated. Future efforts must also focus on determining the impact of socioeconomic status on access to and outcomes of HCT and the long-term impact of HCT on patients, families, and society.

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“…20 In men with SCA, while HU has been shown to worsen already existing testicular dysfunction, 21 other studies have shown no difference in sperm parameters in HU-exposed versus HU nonexposed patients. 22 Given the lack of definitive data on infertility and real-life reports of pregnancy in women on HU and in partners of men on HU, 19 HU remains the drug for SCA with the best risk/benefit profile. 18 In practice, it may be simpler to start this treatment at the same time as penicillin, that is when the diagnosis is made.…”

mentioning

confidence: 99%