Effect of hydroxytyrosol methyl carbonate on the thermal, migration and antioxidant properties of <scp>PVA</scp>‐based films for active food packaging

Fortunati, Elena; Luzi, Francesca; Dugo, Laura; Fanali, Chiara; Tripodo, Giusy; Santi, L.; Kenny, J. M.; Torre, Luigi; Bernini, Roberta

doi:10.1002/pi.5090

Cited by 29 publications

(18 citation statements)

References 40 publications

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“…Hydroxytyrosol 6 is the most relevant compound, characterized by a potent anticancer and antioxidant activity [ 29 ]. It has been widely studied in our laboratories and used for many applications ranging from the synthesis of novel bioactive compounds [ 30 , 31 ] to its inclusion in PVA-based films for active food packaging applications [ 32 , 33 ].…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Evaluation of the Antioxidant Activity of Lipophilic Phenethyl Trifluoroacetate Esters by In Vitro ABTS, DPPH and in Cell-Culture DCF Assays

et al. 2018

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Polyphenols are natural compounds showing a variety of health-promoting effects. Unfortunately, due to low lipid solubility, their applications in the pharmaceutical, food, and cosmetic industries are limited. With the aim of obtaining novel lipophilic derivatives, the present study reports the synthesis of a series of phenethyl trifluoroacetate esters containing up to two hydroxyl groups in the aromatic ring. Experimental logP values confirmed a greater lipophilicity of the novel compounds compared to the parent compounds. The radical scavenging capacity of all phenethyl trifluoroacetate esters was evaluated by in vitro assays (ABTS, DPPH) and in cultured cells (L6 myoblasts and THP-1 leukemic monocytes) using 2′,7′-dichlorodihydrofluorescein diacetate. These data revealed that the esters showed a good antioxidant effect that was strictly dependent on the grade of hydroxylation of the phenyl ring. The lack of toxicity, evaluated by the MTT assay and proliferation curves, makes these trifluoroacetates attractive derivatives for pharmaceutical, food, and cosmetic applications.

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Section: Resultsmentioning

confidence: 99%

Synthesis and Evaluation of the Antioxidant Activity of Lipophilic Phenethyl Trifluoroacetate Esters by In Vitro ABTS, DPPH and in Cell-Culture DCF Assays

et al. 2018

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“…Generally, the migrated value increases with increase of QC (or GA) content in the matrix [26,65]. The presence of GA in PVA films induces a slight increase of migration levels in comparison with PVA/QC based films (PVA/5GA = (6.8 ± 0.1) mg kg −1 and PVA/10GA = (9.9 ± 0.5) mg kg −1 for GA, PVA/5QC = (6.6 ± 0.4) mg kg −1 and PVA/10QC = (9.5 ± 0.4) mg kg −1 for QC).…”

Section: Mechanical Responsementioning

confidence: 99%

Gallic Acid and Quercetin as Intelligent and Active Ingredients in Poly(vinyl alcohol) Films for Food Packaging

et al. 2019

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Gallic acid (GA) and quercetin (QC) were used as active ingredients in poly(vinyl alcohol) (PVA) film formulations obtained by solvent casting process. The effect of two different percentages (5 and 10 % wt.) on morphological behavior, thermal stability, optical, mechanical, and release properties of PVA were investigated, while migration with food stimulants and antioxidant properties were tested taking into account the final application as food packaging systems. The results showed how different dispersability in PVA water solutions gave different results in term of deformability (mean value of ε PVA/5GA = 280% and ε PVA/5QC = 255%, with 190% for neat PVA), comparable values for antioxidant activity at the high contents (Radical Scavenging Activity, RSA(%) PVA/10GA = 95 and RSA(%) PVA/10QC = 91) and different coloring attitude of the polymeric films. It was proved that GA, even if it represents the best antioxidant ingredient to be used with PVA and can be easily dispersed in water, it gives more rigid films in comparison to QC, that indeed was more efficient in tuning the deformability of the PVA films, due the presence of sole hydroxyl groups carrying agent. The deviation of the film coloring towards greenish tones for GA films and redness for QC films after 7 and within 21 days in the simulated conditions confirmed the possibility of using easy processable PVA films as active and intelligent films in food packaging.

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“…In vitro tests confirmed the efficiency of HTyr-MC as a radical scavenger [28] and the lack of cytotoxicity makes it possible to be used as a preservative for food applications [35]. Recently, HTyr-MC was added into poly(vinyl alcohol) (PVA) matrices to obtain novel PVA-based binary films useful for packaging applications, to preserve food susceptible to oxidation [36]. Anticancer assays performed on melanoma (M14), pulmonary (H125), colon (WiDr), and promyelocytic leukaemia (HL60) cell lines revealed that HTyr-MC was more effective than HTyr in cell growth inhibition and apoptosis induction [37].…”

Section: Resultsmentioning

confidence: 99%

Sustainability, Innovation, and Green Chemistry in the Production and Valorization of Phenolic Extracts from Olea europaea L.

et al. 2016

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This paper describes a circular economy process based on environmentally and economically sustainable procedures which was applied to the sector of olive oil processing on an industrial scale. Olea europaea L. tissues and by-products represent a renewable and low-cost source of polyphenols, in particular hydroxytyrosol (HTyr), a naturally occurring compound well known for its biological properties. Specifically, green leaves (GL), dried leaves (DL), and pitted olive pulp were treated with water in a pneumatic extractor to obtain the corresponding polyphenolic extracts. Three standardized fractions, named Soft Extract Olea GL, Soft Extract Olea DL, and Soft Extract Olea HTyr resulted after the following two steps: a separation process carried out by membrane technology, and a concentration step performed under reduced pressure and low temperature. The polyphenolic fractions showed antiradical activity and have potential industrial applications in the food, nutraceutical, pharmaceutical, feed, and agronomic fields. Novel functionalized extracts containing hydroxytyrosol methyl carbonate (HTyr-MC) were obtained from Soft Extract Olea HTyr through an innovative approach based on green chemistry procedures, which appear to be a promising tool to increase the applications of the polyphenolic extracts.

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Effect of hydroxytyrosol methyl carbonate on the thermal, migration and antioxidant properties of PVA‐based films for active food packaging

Cited by 29 publications

References 40 publications

Synthesis and Evaluation of the Antioxidant Activity of Lipophilic Phenethyl Trifluoroacetate Esters by In Vitro ABTS, DPPH and in Cell-Culture DCF Assays

Synthesis and Evaluation of the Antioxidant Activity of Lipophilic Phenethyl Trifluoroacetate Esters by In Vitro ABTS, DPPH and in Cell-Culture DCF Assays

Gallic Acid and Quercetin as Intelligent and Active Ingredients in Poly(vinyl alcohol) Films for Food Packaging

Sustainability, Innovation, and Green Chemistry in the Production and Valorization of Phenolic Extracts from Olea europaea L.

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