Effect of hydroxypropyl cellulose (HPC) on dissolution rate of hydrochlorothiazide tablets

Desai, Divyakant; Rinaldi, Frank; Kothari, Suresh; Paruchuri, Srinivasa; Li, D.; Lai, Ming G.; Fung, Siu Ming; Both, Douglas

doi:10.1016/j.ijpharm.2005.10.011

Cited by 43 publications

(42 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This would explain the differences observed in the experimental or simulated pharmacokinetic parameters for each biobatch, in accordance with that found by Wei et al for glyburide (12). The composition of SLS in biobatch A was drastically reduced (73% less) compared to biobatch B and instead included the addition of hydroxypropylcellulose (Klucel® LF) at a concentration that stabilizes the supersaturated solutions that occur during the process of tablet dissolution (29). The use of Klucel® improved drug dissolution and, consequently, the bioavailability of the drug.…”

Section: Bioequivalence Studiessupporting

confidence: 86%

In Vitro–In Vivo Correlation of Efavirenz Tablets Using GastroPlus®

et al. 2013

View full text Add to dashboard Cite

Abstract. The aim of the present work was to use GastroPlus™ software for the prediction of pharmacokinetic profiles and in vitro-in vivo correlation (IVIVC) as tools to optimize the development of new generic medications. GastroPlus™ was used to simulate the gastrointestinal compartment and was based on the advanced compartmental absorption and transit model. Powder dissolution and efavirenz tablet dissolution studies were carried out to generate data from which correlation was established. The simulated plasma profile, based on the physicochemical properties of efavirenz, was almost identical to that observed in vivo for biobatches A and B. A level A IVIVC was established for the dissolution method obtained for the generic candidate using the Wagner-Nelson (r 2 =0.85) and for Loo-Riegelman models (r 2 =0.92). The percentage of fraction absorbed indicated that 0.5% sodium lauryl sulfate may be considered a biorelevant dissolution medium for efavirenz tablets. The simulation of gastrointestinal bioavailability and IVIVC obtained from immediate-release tablet formulations suggests that GastroPlus™ is a valuable in silico method for IVIVC and for studies directed at developing formulations of class II drugs.KEY WORDS: bioavailability; computational simulation; efavirenz; GastroPlus™; in vivo-in vitro correlation.

show abstract

Section: Bioequivalence Studiessupporting

confidence: 86%

In Vitro–In Vivo Correlation of Efavirenz Tablets Using GastroPlus®

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Cellulose ethers such as MC, HPMC, HEC and HPC have good binding properties in wet granulation. Low substituted cellulose ethers, such as low substituted HPCs (L-HPC), (Desai et al, 2006) have also been used as a binder in wet granulation processes. Even though, low substituted cellulose ethers have lower water solubility compared with normal grades, this is offset by a very good binding efficacy (Chebli & Cartilier, 1998).…”

Section: Cellulose Ethers As a Binder / Compression Enhancer In Tablementioning

confidence: 99%

“…On the basis of these findings, it can the hypothesised that the surface pores might be related to Hpo/Meo ratio as the K-chemistry polymers have a higher ratio than E, F and A chemistry HPMCs. A study conducted by Desai et al, (2006) concluded that the low substituted HPCs have good binding properties in direct and wet tablet granulation processes. However, a higher degree of substitution render HPC more thermoplastic (Parikh, 2016) Moreover, other chemically distinct CE grades (EC and HEC) have also showed acceptable/good compression properties (Desai, 2001;Mark, 2014).…”

Section: Effect Of Chemical Substitutionmentioning

confidence: 99%

Powder Compaction: Compression Properties of Cellulose Ethers

Ghori

Conway

2016

British Journal of Pharmacy

View full text Add to dashboard Cite

Effective development of matrix tablets requires a comprehensive understanding of different raw material attributes and their impact on process parameters. Cellulose ethers (CE) are the most commonly used pharmaceutical excipients in the fabrication of hydrophilic matrices. The innate good compression and binding properties of CE enable matrices to be prepared using economical direct compression (DC) techniques. However, DC is sensitive to raw material attributes, thus, impacting the compaction process. This article critically reviews prior knowledge on the mechanism of powder compaction and the compression properties of cellulose ethers, giving timely insight into new developments in this field.

show abstract

“…Several bioadhesive tablet systems have been the subject of a growing interest [103,[106][107][108][109] in order to improve bioavailability of drug administered across buccal mucosa. Adhesive tablets are small, flat and oval with a diameter approximately of 5-8 mm and about 2 mm in thickness [44].…”

Section: Adhesive Tabletsmentioning

confidence: 99%

Mucoadhesive Polymers for Oral Transmucosal Drug Delivery: A Review

Bagán¹,

Paderni²,

Termine³

et al. 2012

CPD

View full text Add to dashboard Cite

Abstract:The oral mucosa offers an interesting site for the application of dosage forms that release drugs within/throughout the oral mucosa, by assuring a high drug bioavailability for topic and systemic effects. However, the relative permeability of the oral mucosa and the washing effect related to the oral fluids and mechanical stresses must be considered in the formulation of oral dosage forms. Since a sustained drug release can be guaranteed only if dosage forms remain in contact with the oral site of absorption/application for a prolonged time, the development of mucoadhesive dosage forms is mandatory. The mucoadhesion is a complex phenomenon and the mucoadhesive bond consists of two different parts, the mucoadhesive polymers and the mucous substrate. In addition to factors related to the oral mucosa and oral environment features, the physical-chemical characteristics of mucoadhesive polymers must be also considered as factors influencing the mucoadhesive bonds. While it is not possible to modify the mucosal features or it is possible to modify or inhibit only in part certain mucosal processes, the knowledge of polymer properties influencing mucoadhesive bonds allows to modify or to control these properties in developing increasingly effective mucoadhesive systems. The aims of this review are to discuss the several mechanisms and factors behind the phenomenon of mucoadhesion with particular reference to the features of the oral environment, oral mucosa, and polymeric compounds influencing mucoadhesion process. Finally, a brief mention to the main mucoadhesive dosage forms designed for oral transmucosal drug delivery is made.

show abstract

Effect of hydroxypropyl cellulose (HPC) on dissolution rate of hydrochlorothiazide tablets

Cited by 43 publications

References 3 publications

In Vitro–In Vivo Correlation of Efavirenz Tablets Using GastroPlus®

In Vitro–In Vivo Correlation of Efavirenz Tablets Using GastroPlus®

Powder Compaction: Compression Properties of Cellulose Ethers

Mucoadhesive Polymers for Oral Transmucosal Drug Delivery: A Review

Contact Info

Product

Resources

About