2014
DOI: 10.1097/aln.0000000000000375
|View full text |Cite
|
Sign up to set email alerts
|

Effect of Hydroxyethyl Starch on Postoperative Kidney Function in Patients Having Noncardiac Surgery

Abstract: Background Whether intraoperative use of hydroxyethyl starch impairs kidney function remains unknown. The authors thus tested the primary hypothesis that Hextend promotes renal injury in surgical patients. Secondarily, the authors evaluated the dose–outcome relationship, in-hospital and 90-day mortality, and whether the relationship between colloid use and acute kidney injury (AKI) depends on baseline risk for AKI. Methods The authors evaluated the data of 44,176 adults without preexisting kidney failure who… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

2
32
0
1

Year Published

2014
2014
2020
2020

Publication Types

Select...
6
3
1

Relationship

0
10

Authors

Journals

citations
Cited by 55 publications
(35 citation statements)
references
References 32 publications
(32 reference statements)
2
32
0
1
Order By: Relevance
“…Recently, Yates et al showed that in moderate–high‐risk patients GDFT with colloid boluses does not accelerate the recovery of bowel function, reduce complications or impair haemostasis compared with crystalloids . Recent data have suggested that the use of large volumes of colloids administered post‐resuscitation in critically ill patients can increase the risk of death and acute kidney injury (AKI) in critically ill patients, but these results have not been consistently reproduced in the perioperative setting . A recent study has found a dose‐dependent association between the volume of HES administered and the development of AKI.…”
Section: Part B Intraoperative and Postoperative Eras Elementsmentioning
confidence: 99%
“…Recently, Yates et al showed that in moderate–high‐risk patients GDFT with colloid boluses does not accelerate the recovery of bowel function, reduce complications or impair haemostasis compared with crystalloids . Recent data have suggested that the use of large volumes of colloids administered post‐resuscitation in critically ill patients can increase the risk of death and acute kidney injury (AKI) in critically ill patients, but these results have not been consistently reproduced in the perioperative setting . A recent study has found a dose‐dependent association between the volume of HES administered and the development of AKI.…”
Section: Part B Intraoperative and Postoperative Eras Elementsmentioning
confidence: 99%
“…Compared with crystalloid solutions, colloid solutions are generally considered to be more effective volume expanders because of their smaller volume of distribution [ 18 ]. However, several recent reports have suggested that the administration of HES solution is associated with an increased risk of renal dysfunction, coagulation abnormality, and mortality [ 19 21 ]. These adverse effects of HES seem to increase with higher doses [ 20 , 22 ].…”
Section: Introductionmentioning
confidence: 99%
“…Balanced crystalloids should be used in initial resuscitation. Synthetic colloids may expand the intravascular volume more effectively, but have been associated with renal dysfunction [25]. Replacement of fluids in a later stable phase can usually be guided by measured fluid losses and aim for normal distribution of body water, not only expansion of plasma volume.…”
Section: Nutrition Therapy and Fluid And Electrolyte Balancementioning
confidence: 99%