Effect of hydroxyethyl starch infusion on colloid oncotic pressure in hypoproteinemic horses

Jones, Peyton A.; Bain, Fairfield T.; Byars, T. Douglas; David, John; Boston, Raymond C.

doi:10.2460/javma.2001.218.1130

Cited by 57 publications

(56 citation statements)

References 34 publications

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“…One would have to administer four times the volume of electrolyte solution as compared with HES to achieve the same intravascular volume effect (Dietrich, 2001). Based on the literature, we believe that volume expansion with HES causes an increase in colloidosmotic pressure in the intravascular space, resulting in better blood fluidity and a corresponding increase in the supply of oxygen to the tissues (Jones et al, 1997(Jones et al, , 2001Asskali and Foerster, 1999;Dietrich, 2001;Lucas et al, 2006). A single infusion of isotonic or hypertonic saline elevated the TP concentration 8 resp.…”

Section: Discussionmentioning

confidence: 99%

“…A colloidal solution using hydroxyethyl starch (HES) (10%) was applied to treat horses with shock in which haematocrit and total protein (TP) values had dropped significantly (Hermann et al, 1990). The oncotic pressure increased over baseline values in normal ponies and hypoproteinaemic horses using HES (6%) (Jones et al, 1997(Jones et al, , 2001). In a retrospective study, HES infusion stabilized systolic pressure of colic horses during general anaesthesia.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Hydroxyethyl Starch Solution in Normal Horses and Horses with Colic or Acute Colitis

Schusser

Rieckhoff

Ungemach

et al. 2007

Journal of Veterinary Medicine Series A

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SummaryHydroxyethyl starch (HES) solution is an effective colloidal infusion solution in humans for treatment of hypovolaemic shock, but it has not been compared with fluids currently available for use in horses. On the basis of plasma-expanding effect of HES in normal horses, a 10% medium-molecular 200/ 0.5 solution of HES was subsequently tested in hypovolaemic horses. Six normal horses were given five protocols of a single infusion of HES at varying dosage rates (5, 10, 15 ml HES/kg), as well as isotonic saline (15 ml/kg) and hypertonic saline (4 ml/kg b.w.). Dehydrated horses suffering from acute colitis or those which had been treated surgically for ileus of the small or large intestine were given an i.v. infusion of 10 ml HES/kg in combination with 10 ml saline/kg. Clinical data and blood samples for testing were taken before the infusion, and then 10 min, 1 h, 2, 4, 6, 8, 10, 12 and 24 h after infusion (a.i.). A significant decrease in haematocrit was observed in protocol 1-5 for a period of up to 4, 4, 10 h, 10 min and up to 10 min; in group of colitis, during the entire 24-h testing period, and in groups of ileus of small intestine and of large intestine, up to 4 and 10 h a.i. HES decreases better and longer-lasting haematocrit and total protein than either isotonic or hypertonic saline. Half-life of HES increases due to higher dosage (5.83, 7.63 and 11.48 h) and distribution is exclusively intravascular. In normal horses of protocol 1-3 using HES aPTT, sodium and potassium were within the physiological range. Serum amylase activity is increased in horses using HES. On the basis of this clinical study, the decreasing effect of urea and creatinine in colic patients after surgery and fewer instances of postoperative ileus a dosage of 10 ml HES/kg could be recommended.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Hydroxyethyl Starch Solution in Normal Horses and Horses with Colic or Acute Colitis

Schusser

Rieckhoff

Ungemach

et al. 2007

Journal of Veterinary Medicine Series A

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“…Nachteile der kristalloiden Flüssigkeiten sind, dass bereits nach einer Stunde weniger als 10 -20 % im intravaskulären Raum verbleiben (Hardy 2009), die Hämodi-lution sowie die Erniedrigung des kolloidosmotischen Druckes (KOD) entsteht (Muir und Wiese 2004). Der KOD korreliert negativ mit der Menge an verabreichtem RL (Boscan et al 2007), wird aber durch die Administration von kolloidaler Lösung (HAES) erhöht (Jones et al 2001). Zudem kann durch die Verabreichung von HAES das nötige zu verabreichende Volumen um 50 % reduziert werden (Campbell et al 1990).…”

Section: Introductionunclassified

Comparison of the effect of two Ringer-Lactate-Solutions on electrolyte-, lactate- and acid-base-status in horses during balanced long-term-anaesthesia with Isoflurane and Medetomidine

Mayer¹,

Bettschart‐Wolfensberger²,

Junge³

et al. 2014

PHK

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Zusammenfassung: Ziel der Studie war es, den Effekt von zwei Ringer-Laktat-Lösungen (Fresenius ® = RLF, Bichsel ® = RLB) auf Elektrolytund Laktatkonzentration sowie Säure-Basen-Status beim Pferd während einer 6-stündigen Allgemeinanästhesie zu untersuchen. Zehn Pferde wurden mit 10 ml/kg/h RLF oder RLB während der Allgemeinanästhesie infundiert. Natrium (Na), Kalium (K), Chlorid (Cl), ionisiertes Kalzium (iCa), Laktat, pH, pCO 2 und Basenüberschuss (BE) wurden vor und alle 30 Minuten nach Einleitung bestimmt (M30 -M360). Unterschiede zwischen den Gruppen wurden mittels Mann-Whitney-U-Tests analysiert. Statistische Signifikanz wurde bei p < 0,05 festgelegt. Es gab keine signifikanten Unterschiede für Na, K, Cl, pH und BE. Das iCa war bei M150 signifikant höher mit RLF (p = 0,025), war jedoch in beiden Gruppen bereits bei M30 tief und fiel bis M360 weiter ab. Die Laktatkonzentration stieg über die Zeit an und war bei M120 (p = 0,016) und M360 (p = 0,036) signifikant höher mit RLB. Es konnten keine klinisch relevanten Unterschiede nach Verabreichung von RLF oder RLB bei den Elektrolyt-und Laktatkonzentrationen sowie beim Säure-Basen-Status über eine Allgemeinanästhesiezeit von 6 h gezeigt werden.Comparison of the effect of two Ringer-Lactate-Solutions on electrolyte-, lactate-and acid-base-status in horses during balanced long-term-anaesthesia with Isoflurane and MedetomidineThe aim of this study was to compare the effect of two Ringer-Lactate solutions (Fresenius ® = RLF, Bichsel ® = RLB) on electrolyte and lactate concentrations as well as acid-base status of horses undergoing 6 h of general anaesthesia. Ten horses were allocated to receive either RLF or RLB at 10 ml/kg/hour during anaesthesia. Na, K, Cl, ionized Ca, lactate, pH, pCO 2 and BE were measured before and every 30 minutes after induction throughout anaesthesia (M30 -M360). Differences between groups were assessed with Mann-Whitney-U-test. Statistical significance was set at p < 0,05. There were no significant differences in Na, K and Cl, pH, pCO 2 and BE. Ionized Ca was significantly higher with RLF at M150 (p = 0,025), but was already low in both groups at M30 and decreased further until M360. Lactate concentrations increased in both groups over time and was significantly higher with RLB at M120 (p = 0,016) and M360 (p = 0,036). There were no clinically significant differences in electrolyte and lactate concentration as well as acid-base-status after administration of either RLF or RLB during six-hour general anaesthesia in horses. Einleitung

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“…The effect of hetastarch solution on oncotic pressure should be determined via direct measurement of COP versus use of a predictive nomogram to calculate COP from plasma total protein concentrations. 11 The low dosage of hetastarch solution used in the pony of this report was selected on the basis of the aforementioned hemostatic and financial concerns; this dosage probably had minimal effect on the correction of COP because the value after administration of the hetastarch solution was 9.2 mm Hg.…”

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confidence: 99%

Management of hemodynamic changes associated with removal of a large abdominal myofibroblastic tumor in a pony

Boyle

Higgins

Durando

et al. 2004

javma

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A 22-year-old female Welsh-cross pony was evaluated because of intermittent colic, signs of depression, pyrexia, anorexia, muscle wasting with abdominal distention, and weight gain over the preceding 12 months. A large abdominal mass was detected and surgically removed; the hemodynamic alterations and complications caused by the dramatic fluid losses and shifts that can occur in association with removal of a large abdominal mass required extensive postoperative management. Monitoring of clinical and hematologic variables such as attitude, heart rate, mucous membrane color, mean arterial blood pressure, PCV, and plasma total protein concentration provided useful information for successful management of the patient after surgery. On removal, the tumor weighed 19% of the pony's body weight and was characterized as a myofibroblastic tumor. Myofibroblastic tumors should be considered as a differential for large internal abdominal masses in horses, and surgical removal may be feasible and life extending with appropriate postoperative care.

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Effect of hydroxyethyl starch infusion on colloid oncotic pressure in hypoproteinemic horses

Cited by 57 publications

References 34 publications

Effect of Hydroxyethyl Starch Solution in Normal Horses and Horses with Colic or Acute Colitis

Effect of Hydroxyethyl Starch Solution in Normal Horses and Horses with Colic or Acute Colitis

Comparison of the effect of two Ringer-Lactate-Solutions on electrolyte-, lactate- and acid-base-status in horses during balanced long-term-anaesthesia with Isoflurane and Medetomidine

Management of hemodynamic changes associated with removal of a large abdominal myofibroblastic tumor in a pony

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