Effect of Hydrotropic Substances on the Complexation of Sparingly Soluble Drugs with Cyclodextrin Derivatives and the Influence of Cyclodextrin Complexation on the Pharmacokinetics of the Drugs

Solvent effects in the extraction and detection of polycyclic aromatic hydrocarbons from complex oils in complex environments

“…In general, non-covalent cyclodextrin based complexes rely on a variety of intermolecular interactions, including hydrophobic association, intermolecular hydrogen bonding, and electrostatic and steric complementarity [38]. Many of these forces are known to depend strongly on experimental conditions, including in particular the composition of the solvent and the presence of solvent additives [39][40][41]. In this system, cyclodextrin complex formation is required for three distinct roles: extraction of aromatic toxicants from the oil into the cyclodextrin-containing aqueous layer, extraction of a high quantum yield fluorophore from the oil into the cyclodextrin-containing aqueous layer, and facilitation of non-covalent energy transfer from the aromatic analyte donor to the fluorophore acceptor.…”

Interaction of fentanyl with various cyclodextrins in aqueous solutions

“…Therefore, it is considered that the fentanyl molecule is more firmly included in the β‐CD cavity in the fentanyl base–G1‐β‐CD solution than in the fentanyl citrate–G1‐β‐CD solution. As mentioned in the phase solubility section, the K A value decreases with an increase in the hydrophilicity of the substrate [25–30]. Consequently, fentanyl base is more firmly included in the β‐CD cavity than fentanyl citrate.…”

“…also mentioned that with an increase in the hydrophilicity of the substrate, such as that induced by the addition of a charged or hydrophilic moiety, an improved interaction with the polar solvent occurs, lowering the CD complexation strength [25]. This has been further established by changing the polarity of the solvent [25,29–31]. Therefore, in the study reported by Holvoet et al ., it is considered that the presence of a solute such as electrolytes in aqueous buffer solution affect the efficiency of the solubilization of fentanyl base by CDs.…”

Study on the supramolecular system of tetrakis(2-hydroxy-5-sulfonatophenyl)porphyrin with cyclodextrins by spectroscopy

“…It is well known that, because of their unique cavity of hydrophobic interior and polar or hydrophilic exterior, many of organic or inorganic guest molecules can be fully or partly incorporated into the cavities of CD to form inclusion complexes in aqueous solution [7]. The formation of inclusion complex can apparently improve the physical and chemical properties of guests, such as stability against chemical and photochemical degradation [8], control of volatility and sublimation, physical isolation of incompatible compounds, chromatographic separations, taste modification by masking off flavors, unpleasant odor, and controlled release of drugs and flavors [9,10].…”