Effect of hydrophobic protein SP-C on structure and dilatational properties of the model monolayers of pulmonary surfactant

Panaı̈otov, I.; Ivanova, Tz.; Proust, J. E.; Boury, Frank; Denizot, B.; Keough, K. M. W.; Taneva, Svetla G.

doi:10.1016/0927-7765(95)01261-3

Cited by 40 publications

(41 citation statements)

References 31 publications

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“…14,19,20 In summary, the viscoelastic response of an interfacial film submitted to a dilatational mechanical strain was studied using a theoretical approach based on two-dimensional rheology. 21 This approach consists of realizing two types of continuous and monotonic compression of the equilibrated surface layer of a pendant drop: a slow compression and fast compression. We recorded simultaneously the variation of the interfacial tension (i.e., resulting stress) during the slow compression, and after the fast compression, to measure the relaxation of the interface.…”

Section: Methodsmentioning

confidence: 99%

Effect of H₂O−CO₂ Organization on Ovalbumin Adsorption at the Supercritical CO₂−Water Interface

Tewes

Boury

2005

J. Phys. Chem. B

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We have studied the formation of water-CO(2) interfaces in the presence of different concentrations of ovalbumin (OVA) by tensiometry and by means of interfacial rheological measurements to obtain some information on the capacity of protein film to stabilize H(2)O in CO(2) emulsion. The formation of pure water-CO(2) interface can be described as a two-step phenomenon.(1) The CO(2) molecules adsorb onto the water surface and then a reorganization of the interface creates a H(2)O-CO(2) cluster network. This organization occurs at a temperature (40 degrees C) higher than the higher temperature limit (10 degrees C) allowing the formation of crystalline structure called CO(2) clathrate.(2) Our results show that ovalbumin adsorption from bulk concentrations higher than 0.0229 g/L inhibits the cluster formation for a CO(2) pressure less than 80 bar. However, for lower concentrations, the more the CO(2) pressure is close to 80 bar, the more OVA adsorption is reduced by the H(2)O-CO(2) cluster network. Moreover, from a pressure of 90 bar, the affinity of OVA for the interface increases and mixed films made of protein molecules and clusters are obtained for the OVA concentrations lower than 1 g/L.

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Section: Methodsmentioning

confidence: 99%

Effect of H₂O−CO₂ Organization on Ovalbumin Adsorption at the Supercritical CO₂−Water Interface

Tewes

Boury

2005

J. Phys. Chem. B

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“…Surface dilatational viscosity can be considered the deviation from the equilibrium surface tension as the interface expands. Determination of surface viscosity is complicated by its dependence on surface coverage and dilation rate (32,33). Meban (32) showed that surface dilatational viscosity decreases with increasing dilatation rate for rabbit lung surfactant extract.…”

Section: Limitationsmentioning

confidence: 99%

A Theoretical Model of Pulmonary Surfactant Multilayer Collapse under Oscillating Area Conditions

Krueger

Gaver

2000

Journal of Colloid and Interface Science

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“…49 Pulmonary surfactant Curosurf® (Chiesi Pharmaceuticals, Parma, Italy) is a porcine minced pulmonary surfactant extract used in maternity hospitals for the treatment of premature newborns with respiratory distress syndrome. 63 It is produced as an 80 g L -1 whitish dispersion at pH 6.4 and contains phosphatidylcholine (PC) lipids, sphingomyelin(SM), phosphatidylethanolamine (PE), phosphatidylinositol (PI), phosphatidylglycerol (PG) and the hydrophobic proteins SP-B and SP-C. 50,64,65 Curosurf® is considered as a model biomimetic surfactant because its composition and bulk properties are constant from one batch to another and because of its long-term shelf stability. The Curosurf® formulation is compared to pulmonary surfactant obtained from lung lavage in Supplementary Information S1.…”

Section: Iv1 -Materialsmentioning

confidence: 99%

Effect of Nanoparticles on the Bulk Shear Viscosity of a Lung Surfactant Fluid

et al. 2019

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Inhaled nanoparticles (< 100 nm) reaching the deep lung region first interact with the pulmonary surfactant, a thin lipid film lining the alveolar epithelium. To date, most biophysical studies have focused on particle induced modifications of the film interfacial properties. In comparison, there is less work on the surfactant bulk properties, and on their changes upon particle exposure. Here we study the viscoelastic properties of a biomimetic pulmonary surfactant in the presence of various engineered nanoparticles. The microrheology technique used is based on the remote actuation of micron-sized wires via the application of a rotating magnetic field and on timelapse optical microscopy. It is found that particles strongly interacting with lipid vesicles, such as cationic silica (SiO2, 42 nm) and alumina (Al2O3, 40 nm) induce profound modifications of the surfactant flow properties, even at low concentrations. In particular, we find that silica causes fluidification, while alumina induces a liquid-to-soft solid transition. Both phenomena are described quantitatively and accounted for in the context of colloidal physics models. It is finally suggested that the structure and viscosity changes could impair the fluid reorganization and recirculation occurring during breathing.

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Effect of hydrophobic protein SP-C on structure and dilatational properties of the model monolayers of pulmonary surfactant

Cited by 40 publications

References 31 publications

Effect of H₂O−CO₂ Organization on Ovalbumin Adsorption at the Supercritical CO₂−Water Interface

Effect of H₂O−CO₂ Organization on Ovalbumin Adsorption at the Supercritical CO₂−Water Interface

A Theoretical Model of Pulmonary Surfactant Multilayer Collapse under Oscillating Area Conditions

Effect of Nanoparticles on the Bulk Shear Viscosity of a Lung Surfactant Fluid

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Effect of hydrophobic protein SP-C on structure and dilatational properties of the model monolayers of pulmonary surfactant

Cited by 40 publications

References 31 publications

Effect of H2O−CO2 Organization on Ovalbumin Adsorption at the Supercritical CO2−Water Interface

Effect of H2O−CO2 Organization on Ovalbumin Adsorption at the Supercritical CO2−Water Interface

A Theoretical Model of Pulmonary Surfactant Multilayer Collapse under Oscillating Area Conditions

Effect of Nanoparticles on the Bulk Shear Viscosity of a Lung Surfactant Fluid

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Product

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Effect of H₂O−CO₂ Organization on Ovalbumin Adsorption at the Supercritical CO₂−Water Interface

Effect of H₂O−CO₂ Organization on Ovalbumin Adsorption at the Supercritical CO₂−Water Interface