Effect of hydrogen sulphide‐donating sildenafil (ACS6) on erectile function and oxidative stress in rabbit isolated corpus cavernosum and in hypertensive rats

Shukla, Nilima; Rossoni, Giuseppe; Hotston, Matthew; Sparatore, Anna; Soldato, Piero Del; Tazzari, Valerio; Persad, Raj; Angelini, Gianni; Jeremy, Jamie Y.

doi:10.1111/j.1464-410x.2009.08415.x

Cited by 91 publications

(68 citation statements)

References 40 publications

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“…In rabbit corpus cavernosum, ACS6 protects against oxidative stress by stimulating both PKA (H 2 S effect) and PKG (sildenafil effect). There is no specific vasodilatory benefit from H 2 S released by ACS6 (142), which seems to be more or less typical for all synthetic H 2 S-donating drugs.…”

Section: R304 Therapeutic Potential Of H2smentioning

confidence: 95%

The therapeutic potential of hydrogen sulfide: separating hype from hope

Olson

2011

American Journal of Physiology-Regulatory, Integrative and Comp

162

154

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Hydrogen sulfide (H2S) has become the hot new signaling molecule that seemingly affects all organ systems and biological processes in which it has been investigated. It has also been shown to have both proinflammatory and anti-inflammatory actions and proapoptotic and anti-apoptotic effects and has even been reported to induce a hypometabolic state (suspended animation) in a few vertebrates. The exuberance over potential clinical applications of natural and synthetic H2S-“donating” compounds is understandable and a number of these function-targeted drugs have been developed and show clinical promise. However, the concentration of H2S in tissues and blood, as well as the intrinsic factors that affect these levels, has not been resolved, and it is imperative to address these points to distinguish between the physiological, pharmacological, and toxicological effects of this molecule. This review will provide an overview of H2S metabolism, a summary of many of its reported “physiological” actions, and it will discuss the recent development of a number of H2S-donating drugs that show clinical potential. It will also examine some of the misconceptions of H2S chemistry that have appeared in the literature and attempt to realign the definition of “physiological” H2S concentrations upon which much of this exuberance has been established.

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Section: R304 Therapeutic Potential Of H2smentioning

confidence: 95%

The therapeutic potential of hydrogen sulfide: separating hype from hope

Olson

2011

American Journal of Physiology-Regulatory, Integrative and Comp

162

154

View full text Add to dashboard Cite

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“…ROS rapidly inactivate NO, thereby limiting its ability to relax smooth muscle [49]. Studies have also demonstrated that ROS have a central role in inducing apoptosis in cavernosum tissues [49][50].…”

Section: Antioxidant Therapy (Quercetin)mentioning

confidence: 99%

“…Thus, there is overwhelming evidence implicating the role of oxidative stress in the pathophysiology of ED [48]. As a result, antioxidant treatment to regulate ROS is being explored as a potential therapeutic treatment for ED [49].…”

Section: Antioxidant Therapy (Quercetin)mentioning

confidence: 99%

Current Perspectives on Pharmacotherapy Treatments for Erectile Dysfunction

Davis¹,

Nunes²,

Stallmann‐Jorgensen³

et al. 2012

Erectile Dysfunction - Disease-Associated Mechanisms and Novel Insights Into Therapy

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“…In the past few years, a number of articles have addressed the role of some of these H 2 S-donating compounds in the cardiovascular system (35), urology (57), neuroinflammation (34), and ophthalmology (51). The reader is also referred to an excellent review article by Sparatore et al, which highlights these general areas (59).…”

Section: Introductionmentioning

confidence: 99%

Anti-Cancer Activity of New Designer Hydrogen Sulfide-Donating Hybrids

Kashfi

2014

Antioxidants & Redox Signaling

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Significance: Hydrogen sulfide (H 2 S) is likely to join nitric oxide (NO) and carbon monoxide (CO) as the third gaseous transmitter, influencing an array of intracellular signaling cascades. Thus, H 2 S is implicated in numerous physiological processes and in the pathology of various diseases. Recent Advances: H 2 S-donating agents that liberate H 2 S slowly either alone or in combination with NO, the so-called NOSH compounds, are being synthesized, and these have been shown to have great potential against cancer. Critical Issues: An accurate determination of H 2 S levels is challenging. H 2 S and NO share many similar actions; do these similarities act to potentiate each other? Since many actions of H 2 S appear to be mediated through inhibition of inflammation and Nuclear factor kappa-light-chain-enhancer of activated B cells is a central player in this scenario, does S-nitrosylation of this transcription factor by NO affect its S-sulfhydration by H 2 S and vice versa? Future Directions: Deciphering the molecular targets of these novel hybrid agents and having genetically engineered animals should help us move toward targeted therapeutic applications. Human safety data with these new hybrids is essential. Antioxid. Redox Signal. 20, 831-846.

show abstract

Effect of hydrogen sulphide‐donating sildenafil (ACS6) on erectile function and oxidative stress in rabbit isolated corpus cavernosum and in hypertensive rats

Cited by 91 publications

References 40 publications

The therapeutic potential of hydrogen sulfide: separating hype from hope

The therapeutic potential of hydrogen sulfide: separating hype from hope

Current Perspectives on Pharmacotherapy Treatments for Erectile Dysfunction

Anti-Cancer Activity of New Designer Hydrogen Sulfide-Donating Hybrids

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