Effect of Hydrogen Sulfide on Kidney Injury in Rat Model of Crush Syndrome

Tekşen, Yasemin; Kadıoğlu, Emine; Koçak, Cengiz; Koçak, Havva

doi:10.1016/j.jss.2018.10.033

Cited by 13 publications

(9 citation statements)

References 34 publications

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“…Since H 2 S was first described as neuronal modulator in the 1990s [ 26 ], there has been intensive research on H 2 S biochemistry, which is involved in several biological processes. Under physiological conditions, nitrate and nitrite can be recycled in tissues and blood, leading to NO and several enzymes, such as persulfide dioxygenase, quinone oxireductase, sulfite oxidase and rhodanese, catalyze the oxidation of this gasotransmitter into sulfate and thiosulfate [ 24 , [27] , [28] , [29] , [30] ]. Nowadays, H 2 S is acknowledged as an important antioxidant, anti-inflammatory and anti-apoptotic agent [ 31 ], although, this molecule has already been shown as a pro-inflammatory agent [ 32 ].…”

Section: Biological Importance Of H 2 Smentioning

confidence: 99%

“…H 2 S donor has shown beneficial effects on rat model of Crush syndrome, which can lead to AKI [ 27 ]. Crush injury was induced through hindlimb compression for 6 h; animals were treated with H 2 S donor NaHS (100 mmol/Kg ip).…”

Section: Pharmacotherapeutic Applications Of H 2 Smentioning

confidence: 99%

“…Moreover, these animals showed reduced serum urea, creatine kinase and creatinine levels, decreased renal failure and reduced apoptosis upon NaHS treatment in comparison to untreated animals. Thus, NaHS administration helped preventing AKI in animal models with crush injury by reducing oxidative stress, inflammation and apoptosis [ 27 ].…”

Section: Pharmacotherapeutic Applications Of H 2 Smentioning

confidence: 99%

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H2S- and NO-releasing gasotransmitter platform: A crosstalk signaling pathway in the treatment of acute kidney injury

Pieretti

Junho

Carneiro‐Ramos

et al. 2020

Pharmacological Research

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Section: Biological Importance Of H 2 Smentioning

confidence: 99%

Section: Pharmacotherapeutic Applications Of H 2 Smentioning

confidence: 99%

Section: Pharmacotherapeutic Applications Of H 2 Smentioning

confidence: 99%

See 1 more Smart Citation

H2S- and NO-releasing gasotransmitter platform: A crosstalk signaling pathway in the treatment of acute kidney injury

Pieretti

Junho

Carneiro‐Ramos

et al. 2020

Pharmacological Research

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“…As for previously proposed treatments for crush syndrome, carbon monoxide-enriched red blood cells have been shown to be effective against myoglobin and heme protein 34 . Allopurinol 35 and hydrogen sulfide 36 have been shown to be effective for blocking the pathways producing oxidative stress. Dexamethasone 37 , anti-HMGB-1 antibodies 17 , 38 , lactoferrin 39 , icing 40 , and ulinastatin 41 have shown efficacy against the inflammatory cascade.…”

Section: Discussionmentioning

confidence: 99%

Zinc chelator treatment in crush syndrome model mice attenuates ischemia–reperfusion-induced muscle injury due to suppressing of neutrophil infiltration

Haruta

Kobayakawa

Saiwai

et al. 2022

Sci Rep

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In crush syndrome, massive muscle breakdown resulting from ischemia–reperfusion muscle injury can be a life-threatening condition that requires urgent treatment. Blood reperfusion into the ischemic muscle triggers an immediate inflammatory response, and neutrophils are the first to infiltrate and exacerbate the muscle damage. Since free zinc ion play a critical role in the immune system and the function of neutrophils is impaired by zinc depletion, we hypothesized that the administration of a zinc chelator would be effective for suppressing the inflammatory reaction at the site of ischemia–reperfusion injury and for improving of the pathology of crush syndrome. A crush syndrome model was created by using a rubber tourniquet to compress the bilateral hind limbs of mice at 8 weeks. A zinc chelator N , N , N ′, N ′-tetrakis-(2-pyridylmethyl)-ethylenediamine (TPEN) was administered immediately after reperfusion in order to assess the anti-inflammatory effect of the chelator for neutrophils. Histopathological evaluation showed significantly less muscle breakdown and fewer neutrophil infiltration in TPEN administration group compared with control group. In addition, the expression levels of inflammatory cytokine and chemokine such as IL-6, TNFα, CXCL1, CXCL2, CXCR2, CCL2 in ischemia–reperfusion injured muscle were significantly suppressed with TPEN treatment. Less dilatation of renal tubules in histological evaluation in renal tissue and significantly better survival rate were demonstrated in TPEN treatment for ischemia–reperfusion injury in crush syndrome. The findings of our study suggest that zinc chelators contributed to the resolution of exacerbation of the inflammatory response and attenuation of muscle breakdown in the acute phase after crush syndrome. In addition, our strategy of attenuation of the acute inflammatory reaction by zinc chelators may provide a promising therapeutic strategy not only for crush syndrome, but also for other diseases driven by inflammatory reactions.

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“…It also participates in regulating apoptosis, oxidative stress and inflammatory responses [71,72]. Teksen et al [73] found that applying exogenous H 2 S (NaHS) to treat the CS rat model could effectively reduce the expression of kidney injury molecule-1 (KIM-1), neutrophil gelatinase-related lipoprotein (NGAL), TNF-a, TGF-b, and total oxidant, therefore improving kidney anti-oxidant levels. Meanwhile, the levels of blood urea nitrogen (BUN), creatinine (Cre), and creatine kinase (CK) also decreased with the application of NaHS.…”

Section: Hydrogen Sulfide (H 2 S)mentioning

confidence: 99%

Emerging medical therapies in crush syndrome – progress report from basic sciences and potential future avenues

Wang

et al. 2020

Renal Failure

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Crush injury is a disease that is commonly found in victims of earthquakes, debris flows, mine disasters, explosions, terrorist attacks, local wars, and other accidents. The complications that arise due to the crush injury inflicted on victims give rise to crush syndrome (CS). If not treated in time, the mortality rate of CS is very high. The most important measure that can be taken to reduce mortality in such situations is to immediately start treatment. However, the traditional treatment methods such as fluid resuscitation, diuresis, and hemodialysis are not feasible enough to be carried out at the disaster scene. So there is a need for developing new treatments that are efficient and convenient. Because it is difficult to diagnose in the disaster area and reach the treatment equipment and treat on time. It has become a new research needs to be directed into identifying new medical treatment targets and methods using the etiology and pathophysiological mechanisms of CS. In recent years, a large number of new anti-oxidant and anti-inflammatory drug therapies have been shown to be highly efficacious in CS rat/mouse models. Some of them are expected to become specific drugs for the emergency treatment of a large number of patients who may develop CS in the aftermath of earthquakes, wars, and other disasters in the future. Hence, we have reviewed the latest research on the medical therapy of CS as a source for anyone wishing to pursue research in this direction.

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Effect of Hydrogen Sulfide on Kidney Injury in Rat Model of Crush Syndrome

Cited by 13 publications

References 34 publications

H2S- and NO-releasing gasotransmitter platform: A crosstalk signaling pathway in the treatment of acute kidney injury

H2S- and NO-releasing gasotransmitter platform: A crosstalk signaling pathway in the treatment of acute kidney injury

Zinc chelator treatment in crush syndrome model mice attenuates ischemia–reperfusion-induced muscle injury due to suppressing of neutrophil infiltration

Emerging medical therapies in crush syndrome – progress report from basic sciences and potential future avenues

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