Effect of hydro-alcoholic extract of &lt;i&gt;Ziziphus spina-christi&lt;/i&gt; against scopolamine-induced anxiety in rats

Setorki, Mahbubeh

doi:10.3329/bjp.v11i2.26505

Cited by 10 publications

(5 citation statements)

References 18 publications

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“…The present work found that the effects of pretreatment with crude extract exhibited a remarkable gephyrin expression in brain tissues similar to those of diazepam group as compared to those of PTZ-kindled mice. The finding reinforced the sedative effect of Zizyphus spina christi leaf extract and it is in harmony with that of previous study (5) . This sedative nature of Zizyphus crude extract may be related to its peptide, cyclopeptide alkaloids, and saponin contents.…”

Section: Discussionsupporting

confidence: 91%

“…PTZ originally acts as an antagonist on GABA receptor. Owing to presence of miscellaneous bioactive compounds such as alkaloids, flavonoids, steroids, phenols and saponins in Zizyphus spina christi (14,15) , it was disclosed that its extract possess diverse pharmacological effects against the brain disorders such as anti-anxiety effect (5) , attenuation of memory impairment induced via scopolamine (16) , and neuroprotection against cerebral ischemia (6) . The present work found that the effects of pretreatment with crude extract exhibited a remarkable gephyrin expression in brain tissues similar to those of diazepam group as compared to those of PTZ-kindled mice.…”

Section: Discussionmentioning

confidence: 99%

“…Different portions of this plant have been widely utilized in folk medicine. On the central nervous system (CNS) level, some of laboratory studies have shown that the extract of Zizyphus spina christi has antianxiety, neuroprotective as well as central inhibitory effect on rodents (5)(6)(7)(8). Thus, current study aimed to investigate the neuroprotective effect of crude Zizyphus spina christi extract against PTZ-induced kindling.…”

Section: Introductionmentioning

confidence: 98%

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Zizyphus spina christi Effect on Pentylenetetrazole-Induced Kindling

Al-Humaidhi¹,

Abd²,

Ghazi³

2021

IraqiJMS

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Background: Epilepsy is a common disorder of brain that is not well controlled via drugs available for it. Gephyrin, a well-known inhibitory synaptic regulator, has a role in epilepsy. Additionally, significant development of oxidative stresses tends to be involved in epileptic seizure pathophysiology that giving rise to neuronal cell death. Zizyphus spina christi is a vastly available Iraqi tree and its leaves have several beneficial effects on central nervous system level. Objective: To investigate the possible neuroprotective effect of crude Zizyphus spina christi extract in kindling model induced. Methods: The removed brains of forty albino male mice from four separate groups were exposed to immunohistochemical test for gephyrin, glutathione, and NeuN expressions. Results: The data found that pretreatment with Zizyphus spina christi crude extract shows highly significant difference (P value <0.001) in immunohistochemical scores for all studied parameters as compared with those being of pentylenetetrazole-kindled group. Conclusion: These findings suggest that crude Zizyphus spina christi extract of leaves is effective in protection against kindling that induced via pentylenetetrazole when applied orally for male mice. Keywords: Gephyrin; glutathione; kindling; NeuN; pentylenetetrazole; Zizyphus spina christi Citation: Al-Humaidhi AM, Abd AH, Ghazi HF. Zizyphus spina christi effect on pentylenetetrazole-induced kindling. Iraqi JMS. 2021; 19(1): 49-55. doi: 10.22578/IJMS.19.1.7

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

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Zizyphus spina christi Effect on Pentylenetetrazole-Induced Kindling

Al-Humaidhi¹,

Abd²,

Ghazi³

2021

IraqiJMS

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“…These considerations provide evidence for the development of new agents with less adverse effects (Predictable SEAU, 2006). In the search for a novel drug product for the treatment of psychiatric illness, large number of medicinal plants such as Areca catechu (Dar and Khatoon, 1997), Capsicum annuum (Jawad et al, 2017), Crocus sativum (Hosseinzadeh and Noraei, 2009), Hypericum perforatum (Kumar et al, 2000), Melissa officinalis (Akhondzadeh et al, 2003), Morus alba (Yadav et al, 2008), Nigella sativa (Raza et al, 2007), and Ziziphus spina-christi (Setorki, 2016) have been investigated for their therapeutic potential in variety of animal models.…”

Section: Introductionmentioning

confidence: 99%

Anxiolytic and hypnotic effects of Cocculus laurifolius leaf extract in mice

Maqbool

Younus

2019

Bangladesh J Pharmacol

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The present study aims to assess the anxiolytic and hypnotic activity of ethanolic extract of Cocculus laurifolius leaf in mice. Anxiolytic activity was observed using behavioral paradigms while hypnotic activity was assessed by sodium pentobarbital induced hypnosis in mice. Animals were treated with the extract at dose 200 and 400 mg/kg orally for 30 days. Anxiolytic and hypnotic effect were observed on day 1, 7, 15 and 30 of treatment. Significant increase in the number of entries and time spent in open arm were observed in elevated plus maze. Similar results were observed in light/dark, open field and hole board test. The anxiolytic effect was substantially greater at dose 200 mg/kg in comparison to dose 400 mg/kg. Minimal hypnotic activity was observed with decrease in onset and prolongation in duration of sleep at dose 400 mg/kg, while dose 200 mg/kg did not produce any hypnotic effect. These results showed that the ethanolic extract of C. laurifolius leaf might have potential anxiolytic and hypnotic activity in mice.

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“…The leaves contain phytosterols such as β-sitosterol, glycoside, flavonoids, saponins, tannins and lactone (Asgarpanah and Haghighat, 2012). Hydroalcoholic extract of Ziziphus spina-christi was found to be effective against scopolamine-induced anxiety in rats (Setorki, 2016). There is no previous study on the learning and memory-enhancing activities of Z. spina- …”

mentioning

confidence: 98%

Neuroprotective effect of <i>Ziziphus spina-christi</i> on brain injury induced by transient global cerebral ischemia and reperfusion in rat

Setorki

Hooshmandi

2017

Bangladesh J Pharmacol

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Neuroprotective effect of Neuroprotective effect of Neuroprotective effect of Ziziphus Ziziphus Ziziphus spina spina spina---christi christi christi on brain injury inon brain injury inon brain injury induced by transient global cerebral duced by transient global cerebral duced by transient global cerebral ischemia and reperfusion in rat ischemia and reperfusion in rat ischemia and reperfusion in rat BJP IntroductionCerebral ischemia occurs when the blood supply to the brain is halted or reduced (Bhuiyan and Kim, 2010). Several factors such as thrombosis, embolism, and systemic hypoperfusion can lead to ischemia (Lakhan et al., 2009). Ischemia reduces the delivery of oxygen and nutrients to the cell which eventually leads to organ dys -function. A reduction of oxygen supply reduces cellular ATP. Required ATP is produced through anaerobic respiration. This leads to an accumulation of lactate, acidosis and finally cell death (Wells et al., 2010).The hippocampus, which plays important roles in learning, memory and emotion, is highly vulnerable to ischemic insults. Hypoxia in this region can lead to inhibition of synaptic potential which is a key mechanism to reduce energy consumption (Meilandt et al., 2004). I/R-induced generation of reactive oxygen species can cause oxidative damage to biomolecules such as lipids, proteins and DNA (Chan, 2001). Increased production of ROS during cerebral ischemia has been considered as a major factor in delayed neuro-nal cell death, especially in hippocampal CA1 pyrami-dal neurons (Hara and Mori, 2000). Anti-oxidant agents may be effective in the treatment of memory and learning deficits. Recently, natural anti-oxidants from plant materials have been reported to reduce neuronal damage caused by free radical (Pham-Huy et al., 2008).Sidr tree (Ziziphus spina-christi, Family Rhamnaceae) is an evergreen tree native to the South of Iran. It has pulpy edible fruits. Traditionally, its leaves are used to treat sores, pneumonia, dysentery, ulcer and as an antiseptics. The leaves contain phytosterols such as β-sitosterol, glycoside, flavonoids, saponins, tannins and lactone (Asgarpanah and Haghighat, 2012). Hydroalcoholic extract of Ziziphus spina-christi was found to be effective against scopolamine-induced anxiety in rats (Setorki, 2016). There is no previous study on the learning and memory-enhancing activities of Z. spina- AbstractThis study evaluated the protective effect of Ziziphus spina-christi on the cerebral oxidative stress and damage induced by ischemia. Male Wistar rats were divided randomly into six groups (seven in each group): Control group did not undergo surgery and received distilled water; shame group underwent surgery without ischemia; ischemic group underwent ischemia without any medication; extract-treated groups underwent ischemia and orally received 50, 100, 200 mg/kg/day doses Z. spina-christi extract. After behavioral tests, anti-oxidant capacity and malondialdehyde level of brain and serum were determined. Treatment of ischemic rats with extract significantly i...

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Effect of hydro-alcoholic extract of <i>Ziziphus spina-christi</i> against scopolamine-induced anxiety in rats

Cited by 10 publications

References 18 publications

Zizyphus spina christi Effect on Pentylenetetrazole-Induced Kindling

Zizyphus spina christi Effect on Pentylenetetrazole-Induced Kindling

Anxiolytic and hypnotic effects of Cocculus laurifolius leaf extract in mice

Neuroprotective effect of <i>Ziziphus spina-christi</i> on brain injury induced by transient global cerebral ischemia and reperfusion in rat

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