Abstract:The chemical carcinogen hydrazine is a potent stimulator of guanylate cyclase. In the
present investigation we found that three chemical carcinogens structurally related to hydrazine,
isonicotinic acid hydrazide, hydrazine sulfate, and dimethylhydrazine, decreased guanylate cyclase
activity. It is of interest that hydrazine has been shown to increase DNA synthesis whereas
isonicotinic acid hydrazide, hydrazine sulfate, and dimethylhydrazine decrease DNA synthesis.
The relationship, if any, linking the guanylat… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.