Effect of Hydrazides on Liver Alanine and Aspartate Transaminases and Lactate Dehydrogenase in Developing Chick Embryos¹

Abstract

Aminoguanidine (5 μmoles/embryo), isoniazid (5 μmoles/embryo), iproniazid (5 μmoles/embryo), isocarboxazid (3 μmoles/embryo), nialamide (5—15 μmoles/embryo) and 4‐deoxypyridoxine (10—30 μmoles/embryo) decreased liver aspartate transaminase activity but increased liver alanine transaminase activity in chick embryo in vivo. This effect was of long duration, after a single dose (5 μmoles) of nialamide or isoniazid it lasted at least 70 hours. Liver lactate dchydrogenase activity was significantly decreased only after 15 μmoles of nialamide per embryo. A temporary increase in liver α‐ketoglutaric and pyruvic acid content was seen after 15 μmolcs of nialamide. In rats nialamide had no effect on liver transaminase activities.