Effect of hyaluronan on the healing of partially ruptured anterior cruciate ligament of rabbits

Kikuchi, T; Fukui, Naoshi; Sakuta, Tomohiro; Yamaguchi, Takahiro; Nakai, Hiroya; Oda, Hiromi

doi:10.1007/bf01239756

Cited by 5 publications

(5 citation statements)

References 23 publications

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“…Wiig et al 39 found that HA treatment improved the healing of ACLs injured with a hole-like defect compared to saline-treated ACLs by improving the healing grade according to the degree of repair in gross morphology, increasing Type III collagen and decreasing the inflammatory response. Kikuchi et al 40 found that HA treatment improved the healing of partially transected ACLs compared to saline-treated controls by decreasing the scarred areas, and stimulating and then reducing proteoglycan production. 40 However, the mechanical properties of injured ACLs were not evaluated in those studies.…”

Section: Discussionmentioning

confidence: 99%

“…Kikuchi et al 40 found that HA treatment improved the healing of partially transected ACLs compared to saline-treated controls by decreasing the scarred areas, and stimulating and then reducing proteoglycan production. 40 However, the mechanical properties of injured ACLs were not evaluated in those studies. In our current study, HA-treated MCL allografts had a 2 MPa increase in failure stress when compared to untreated allografts, while other mechanical property comparisons revealed no HArelated improvements.…”

Section: Discussionmentioning

confidence: 99%

“…Wiig et al 39 found that rabbit ACLs with central hole-like defects treated with HA had significantly improved filling of the defect, increased collagen III synthesis, increased angiogenesis, and decreased inflammation compared to saline-treated ACLs. Kikuchi et al 40 investigated the healing of partially transected rabbit ACLs and found that HA treatment facilitated tissue repair and inhibited the formation of scar tissue. In an in vitro study of rabbit ACL cells, Kikuchi et al 41 found that HA promoted the production of the large-molecular-weight proteoglycan, versican, and facilitated extracellular matrix formation.…”

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confidence: 99%

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Healing ligament mechanical properties are improved by repair with interpositional allografts but not by concomitant treatment with hyaluronic acid

Thornton¹,

Shao²,

Kuchison³

et al. 2009

Journal Orthopaedic Research

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Healing ligaments have inferior mechanical properties compared to normal ligaments during early healing intervals. The purpose of this study was to investigate if in vivo ligament repair with an interpositional allograft and treatment with hyaluronic acid (HA) would improve the mechanical properties of a medial collateral ligament (MCL) healing from a gap injury. Twenty rabbits were assigned equally to either a donor or recipient group. A gap injury of the MCL was created in both hindlimbs of 10 recipient animals. The right hindlimb was treated with allograft plus HA while the left hindlimb was treated with allograft only. Low-load and high-load mechanical properties, including laxity, relaxation and failure, and histology were evaluated after 6 weeks of healing. Mechanical results were compared to previously published normal MCL and MCL gap scar data. MCL allografts had greater initial force during cyclic relaxation testing and maximum force during failure testing than MCL scars, but were weaker than normal MCLs. Failure stress was the only parameter to demonstrate a statistically significant effect of treatment with HA on the allografts. However, the failure stress of the HA-treated MCL allografts was not different than MCL scars and was less than normal MCLs. In conclusion, interpositional allografts could enhance some mechanical properties of ligament healing but HA, in the way we applied it, did not produce an obvious improvement. ß

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Healing ligament mechanical properties are improved by repair with interpositional allografts but not by concomitant treatment with hyaluronic acid

Thornton¹,

Shao²,

Kuchison³

et al. 2009

Journal Orthopaedic Research

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“…These studies revealed similar findings according to the mechanisms to promote healing. However, 2 studies reported the positive effects of hyaluronan with repeated intra-articular injection, 24 , 28 which may represent a different mechanism for biological modulation of ACLR.…”

Section: Discussionmentioning

confidence: 99%

Systematic Review of Biological Modulation of Healing in Anterior Cruciate Ligament Reconstruction

Cheuk

Yung

et al. 2014

Orthopaedic Journal of Sports Medicine

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Background:Whether biological modulation is effective to promote healing in anterior cruciate ligament (ACL) reconstruction remains unclear.Purpose:To perform a systematic review of both clinical and experimental evidence of preclinical animal studies on biological modulation to promote healing in ACL reconstruction.Study Design:Systematic review; Level of evidence, 2.Methods:A systematic search was performed using the PubMed, Ovid, and Scopus search engines. Inclusion criteria were clinical and animal studies involving subjects with ACL injury with the use of biological modulation to promote healing outcomes. Methodological quality of clinical studies was evaluated using the Critical Appraisal Skill Programme (CASP) appraisal tool, and animal studies were evaluated by a scoring system based on a published checklist of good animal studies.Results:Ten clinical studies and 50 animal studies were included. Twenty-five included studies were regarded as good quality, with a methodological score ≥5. These studies suggested that transforming growth factor–beta (TGF-β), mesenchymal stem cells, osteogenic factors, and modalities that reduce local inflammation may be beneficial to promote graft healing in ACL reconstruction.Conclusion:This systematic review suggests that biological modulation is able to promote healing on top of surgical treatment for ACL injuries. This treatment strategy chiefly works through promotion of healing at the tunnel-graft interface, but the integrity of the intra-articular midsubstance of the graft would be another target for biological modulation.

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“…The treatment regimen of SH-treated group was determined according to the previously described method. 18 The treatment regimen of XG-treated group was determined according to our pilot experimental results. 16 The animals were sacrificed in the sixth week by an intravenous overdose of anesthesia.…”

Section: Experimental Oa Model and Treatment Regimensmentioning

confidence: 99%

Xanthan gum inhibits cartilage degradation by down-regulating matrix metalloproteinase-1 and -3 expressions in experimental osteoarthritis

Han

Mei

Ling

et al. 2014

Journal of Bioactive and Compatible Polymers

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We previously reported that intra-articular injection of xanthan gum protected the joint cartilage and reduced osteoarthritis progression. In this study, the effects of xanthan gum on chondrocytes apoptosis were evaluated using the labeling assay, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assay, to determine the protein expression of matrix metalloproteinase-1, 3, and tissue inhibitors of metalloproteinase-1 using immunohistochemistry and Western blot assay in cartilage of papain-induced rabbit osteoarthritis model. Compared to the negative control group, intra-articular injection of xanthan gum, once every 2 weeks for 5 weeks significantly inhibited chondrocytes apoptosis and matrix metalloproteinase-1 and -3 protein expression levels and also enhanced the tissue inhibitors of metalloproteinase-1 production in cartilage. No significant differences between the xanthan gum-treated group and the sodium hyaluronate-treated group (intra-articular injection of sodium hyaluronate only once a week for 5 weeks) were observed.

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Effect of hyaluronan on the healing of partially ruptured anterior cruciate ligament of rabbits

Cited by 5 publications

References 23 publications

Healing ligament mechanical properties are improved by repair with interpositional allografts but not by concomitant treatment with hyaluronic acid

Healing ligament mechanical properties are improved by repair with interpositional allografts but not by concomitant treatment with hyaluronic acid

Systematic Review of Biological Modulation of Healing in Anterior Cruciate Ligament Reconstruction

Xanthan gum inhibits cartilage degradation by down-regulating matrix metalloproteinase-1 and -3 expressions in experimental osteoarthritis

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