Effect of hyaluronan and metronidazole gels in management of chronic periodontitis

Mahmood, Athraa A; Abdul-wahab, Ghasaq A.; Al-Karawi, Sarah Ihsan

doi:10.4103/jioh.jioh_292_18

Cited by 8 publications

(7 citation statements)

References 33 publications

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“…This finding was in agreement with earlier studies[ 26 27 ] which found improvement in gingival health after supragingival HA application in patients with gingivitis. Besides, both Shah et al [ 28 ] and Mahmood et al [ 29 ] used HA gel subgingivally and agreed with our study; they revealed a greater, significant improvement of CPPs in the HA group when compared with scaling and root planing alone. This could be because the HA has an anti-inflammatory influence created by the scavenger effect of HA through the draining of prostaglandins, metalloproteinase, and other bioactive molecules.…”

Section: Discussionsupporting

confidence: 91%

Assessment of the Plaque-Induced Gingivitis Patient With and Without Hyaluronic acid and Xylitol Toothpaste

Talib

Mousa

Mahmood

2021

Journal of International Society of Preventive and Community Dentistry

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Section: Discussionsupporting

confidence: 91%

Assessment of the Plaque-Induced Gingivitis Patient With and Without Hyaluronic acid and Xylitol Toothpaste

Talib

Mousa

Mahmood

2021

Journal of International Society of Preventive and Community Dentistry

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“…Recently, a topical mixture of chemical and mechanical treatments such as metronidazole and HA, which has been described as a supplementary therapeutic measure for periodontitis, was reported to afford strong recovery. 19 HA is naturally present in the connective tissue of humans. It is involved in the healing process when it apply topically as agel wherein it reduces bleeding, gingival crevicular ﬂuid, and lysosomal enzymes (hyaluronidase and chondroitinase) without triggering immunological reactions as adverse side effects.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the formulation decreased exudate volume and pain, which in turn improved wound appearance. 19 , 32 The promising synergistic mix formulation has been derived from local etiological elements to eradicate local inflammation and accelerate tissue healing. The present study showed an obvious synergistic effect of HA, rosemary oil, and metronidazole to achieve better wound healing.…”

Section: Discussionmentioning

confidence: 99%

The efficacy of a new paste formulation as an alternative therapeutic agent for traumatic ulcers

Abid¹,

Naser

2021

Journal of Taibah University Medical Sciences

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Objectives The present study aims to evaluate the healing effect of a new topical paste formulation on mucosal wounds. Methods This study was conducted in 40 adult male rabbits. The animals were divided into two groups: a control group containing rabbits that were treated with only Orabase paste (comprising olive oil and beeswax) and an experimental group that included rabbits that were treated with Orabase paste containing hyaluronic acid, rosemary extract, and metronidazole. Each of these groups was randomly divided into four groups according to the observational period (post-treatment days 1, 3, 7, and 15). Further, biopsy samples for histological examination were obtained from the animals’ oral mucosal defects. Results We found that the new formulation (Orabase paste containing hyaluronic acid, rosemary extract, and metronidazole) had a stronger healing effect. The inflammation and re-epithelization scores at 3–7 days for the experimental group appeared superior in which ( P -values were 0.038 and 0.034 for inflammation and 0.046 and 0.025 for re-epithelization) respectively. Furthermore, the re-epithelization score on the 15th day for the new formulation was significant ( P ≤ 0.05), with the inflammatory response being milder. Conclusions Topical application of new paste formulation provided good therapeutic results. The new formulation was effective in resolving inflammation during specific phases of mucosal healing and significantly advanced wound healing at different stages. It also afforded a better healing response in terms of reduced wound contraction.

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“…The preliminary results suggested that the use of HAplus gel loaded with vitamins C and E could be beneficial in patients with conditions that impair soft tissue healing [159]. Local applications of metronidazole and 0.2% HA gels as an auxiliary to conventional periodontal therapy have a useful impact on clinical periodontal parameter during 7 days in chronic periodontitis patients [160].…”

Section: Dentistrymentioning

confidence: 99%

Hyaluronan as a Prominent Biomolecule with Numerous Applications in Medicine

Valachová

Šoltés

2021

IJMS

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Hyaluronan (HA) is a natural glycosaminoglycan present in many tissues of all vertebrates. HA has various biological functions, which are dependent on its molar mass. High-molar-mass HA has anti-angiogenic, immunosuppressive and anti-inflammatory properties, while low-molar-mass HA has opposite effects. HA has also antioxidative properties, however on the other hand it can be readily degraded by reactive oxygen species. For many years it has been used in treatment of osteoarthritis, cosmetics and in ophthalmology. In the last years there has been a growing interest of HA to also be applied in other fields of medicine such as skin wound healing, tissue engineering, dentistry and gene delivery. In this review we summarize information on modes of HA administration, properties and effects of HA in various fields of medicine including recent progress in the investigation of HA.

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Effect of hyaluronan and metronidazole gels in management of chronic periodontitis

Cited by 8 publications

References 33 publications

Assessment of the Plaque-Induced Gingivitis Patient With and Without Hyaluronic acid and Xylitol Toothpaste

Assessment of the Plaque-Induced Gingivitis Patient With and Without Hyaluronic acid and Xylitol Toothpaste

The efficacy of a new paste formulation as an alternative therapeutic agent for traumatic ulcers

Hyaluronan as a Prominent Biomolecule with Numerous Applications in Medicine

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