Effect of humulus lupulus on Gastric Secretion in a Rat Pylorus-Ligated Model

Kurasawa, Takashi; Chikaraishi, Yoshito; Naito, Akira; Toyoda, Yoshihiro; Notsu, Yoshitada

doi:10.1248/bpb.28.353

Cited by 28 publications

(25 citation statements)

References 17 publications

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“…In the present experiments, three different doses, high (200 mg/kg), middle (100 mg/kg) and low (50 mg/kg), were adopted to avoid the possibility of insufficient dosage, and an animal model was modified according to reported methods [11,18,30] . The anaesthetized rat model provides an opportunity to investigate the mechanisms of gastric antibiotic transfer.…”

Section: Amoxicillin Concentration In Gastric Mucosa and The Effect Omentioning

confidence: 99%

Transfer and distribution of amoxicillin in the rat gastric mucosa and gastric juice and the effects of rabeprazole

Zheng

Bao

et al. 2010

Acta Pharmacol Sin

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Aim: To investigate the distribution of amoxicillin in the gastric juice and gastric mucosa of rats and to investigate the effects of proton pump inhibitor rabeprazole on amoxicillin concentrations in various compartments. Methods: One hundred and sixty anesthetized rats were divided into five groups, and given intravenously different doses of amoxicillin or amoxicillin and rabeprazole. The pH value and volume of gastric juice was aspirated were measured and separated gastric mucosa was homogenized. The concentrations of amoxicillin in the plasma, gastric juice and gastric mucosa were measured by high performance liquid chromatography (HPLC). Results: The maximum concentrations of amoxicillin in gastric juice and gastric mucosa were significantly lower than those in plasma (P<0.001). Concentrations in the glandular stomach mucosa were higher than those in the forestomach mucosa. Rabeprazole did not significantly change the pharmacokinetic parameters of amoxicillin in the plasma and did not alter gastric antibiotic clearance or the gastric transfer fraction of amoxicillin in gastric juice. However, rabeprazole did increase the amoxicillin concentration and pH value in gastric juice and reduced the volume of the gastric juice. Conclusion: Amoxicillin could penetrate the gastric mucosa and achieve therapeutic concentrations at the target site after transfer from the blood to the stomach. Rabeprazole increased the amoxicillin concentration in gastric juice by decreasing the gastric juice volume but did not affect its concentration in blood or gastric mucosa.

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Section: Amoxicillin Concentration In Gastric Mucosa and The Effect Omentioning

confidence: 99%

Transfer and distribution of amoxicillin in the rat gastric mucosa and gastric juice and the effects of rabeprazole

Zheng

Bao

et al. 2010

Acta Pharmacol Sin

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“…After 15 min of ethanol administration, all the animals were sacrificed using anaesthetic ether. Gastric volume was measured by pylorus ligation method [18] . Each stomach was opened along the greater curvature and examined macroscopically for gastric erosions under a dissecting microscope (20 X).…”

Section: Phytochemical Screeningmentioning

confidence: 99%

Anti-Ulcer (Ulcer-Preventive) Activity of Ficus arnottiana Miq. (Moraceae) Leaf Methanolic Extract

Marslin¹,

Vithalrao²,

Franklin³

et al. 2009

American J. of Pharmacology and Toxicology

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Problem statement: In spite of being one of the well-known medicinal plants used in Indian traditional medicine to treat several ailments, studies pertaining to the pharmacological properties of Ficus arnottiana are very scarce. We studied the anti-ulcer activity and acute toxicity of Ficus arnottiana leaf methanolic extract for the first time. Approach: Freshly collected F. arnottiana leaves were dried, powdered and extracted in methanol. To study the anti-ulcer activity, Wistar rats were orally administered with different doses of the extract (0, 250 and 500 mg kg −1 body weight day −1 ) or with the reference drug omeprazole (8 mg kg −1 ) for 10 days. After induction of ulcer using 5 mL kg −1 ethanol, stomachs of these animals were analyzed for gastric volume, ulcer area and gross pathological changes. Results: Our results showed that F. arnottiana methanolic extract could prevent ulcer in rats in a dose-dependent manner. Histological studies revealed that the extract had mucoprotective activity. The extract did not show any acute toxicity even at the dose of 5000 mg kgindicating that the extract has no lethal effect. Preliminary phytochemical screening of this extract identified the presence of important secondary metabolites like flavonoids and tannins. Conclusion/Recommendations: From this study, it is clear that F. arnottiana leaf extract had significant anti-ulcer activity in animal models. It had muco-protective activity and gastric antisecretary activity. The extract is non-toxic even at relatively high concentrations.

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“…Infusion or decoction of hop cones intensifies digestion, they are recommended in kidney and liver diseases, gastritis, dropsy, jaundice, neuralgia, insomnia [6].…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, we consider it advisable to conduct research on the development of the composition and technology of a solid dosage form for the treatment of pathologies caused by inflammation in the internal organs, for example gastritis or gastric ulcer [4,6].…”

Section: Substantiation Of the Medicine With Dry Extract Of Hop Conesmentioning

confidence: 99%

Substantiation of the Medicine With Dry Extract of Hop Cones in the Form of Hard Gelatine Capsules for Treatment of Gastrointestinal Diseases Development Expediency

Kutsenko

Гербіна

2017

Technology transfer: innovative solutions in medicine

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The aim of the work was to justify the feasibility of developing a new drug with a dry extract of hop cones in the form of hard gelatin capsules for the treatment of gastrointestinal diseases. Methods. In order to study the range of medicines based on hop cones on the pharmaceutical market of Ukraine, a marketing analysis of registered drugs has been conducted. The marketing analysis was carried out using the information of retrieval system "Drugs" by "Morion" LLC and the State Register of Medicines of Ukraine, which allows quickly tracking changes in the structure of offers. To systematize the main characteristics of the studied drug of hop cones, to assess its strengths and weaknesses, opportunities and threats, a modern marketing method – SWOT-analysis has been used. In the process of research, methods of system analysis, monitoring, logical generalization, grouping of marketing research, etc. were used. Results. The methodology of research has been developed and justified. The main types of pharmacological activity of extracts from hop raw materials have been reviewed. A comprehensive study of the drug from hop cones using the SWOT-analysis method has allowed analyzing its strengths and weaknesses, which can contribute to or hamper the progress and consolidation of this drug in a certain market segment. It was revealed that the strengths of the drug are much greater than the weaknesses, and this speaks in favor of its competitiveness in the pharmaceutical market of Ukraine. The discussion of the results. The medical and marketing expediency of developing a new medicinal preparation with a dry extract of hop cones in the form of capsules for use in gastroenterology have been proved

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Effect of humulus lupulus on Gastric Secretion in a Rat Pylorus-Ligated Model

Cited by 28 publications

References 17 publications

Transfer and distribution of amoxicillin in the rat gastric mucosa and gastric juice and the effects of rabeprazole

Transfer and distribution of amoxicillin in the rat gastric mucosa and gastric juice and the effects of rabeprazole

Anti-Ulcer (Ulcer-Preventive) Activity of Ficus arnottiana Miq. (Moraceae) Leaf Methanolic Extract

Substantiation of the Medicine With Dry Extract of Hop Cones in the Form of Hard Gelatine Capsules for Treatment of Gastrointestinal Diseases Development Expediency

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